Tag: pharmaceutical quality

Addressing Residual Solvent Levels in Coated Tablets During In-Process Control

March 12, 2025 Admin

Addressing Residual Solvent Levels in Coated Tablets During In-Process Control Addressing Residual Solvent Levels in Coated Tablets During In-Process Control Introduction: The pharmaceutical industry is governed by stringent regulations to ensure the safety, efficacy, and quality of products. One critical aspect of manufacturing coated tablets is managing residual solvent levels during in-process control. Residual solvents…

Solid Dosage form, Tablets

Managing Failures in Stress Tests for Sustained Release Tablets

March 12, 2025 Admin

Managing Failures in Stress Tests for Sustained Release Tablets Managing Failures in Stress Tests for Sustained Release Tablets Introduction: Sustained release tablets are critical in modern pharmaceutical formulations, offering controlled drug release over extended periods. These tablets enhance patient compliance by reducing the frequency of dosing and maintaining therapeutic drug levels. However, ensuring their effectiveness…

Solid Dosage form, Tablets

Ensuring Adequate Calibration of Equipment in Coating Processes

March 12, 2025 Admin

Ensuring Adequate Calibration of Equipment in Coating Processes Ensuring Adequate Calibration of Equipment in Coating Processes Introduction: In the pharmaceutical industry, the coating of tablets is a critical process that not only enhances the aesthetic appeal of the product but also plays a vital role in controlling the release profile of the active pharmaceutical ingredient…

Solid Dosage form, Tablets

Poor correlation between accelerated and real-time stability results.

March 12, 2025 Admin

Poor correlation between accelerated and real-time stability results. Poor correlation between accelerated and real-time stability results. Introduction: Stability testing is an essential component of the pharmaceutical development process. It ensures that a drug product maintains its intended physical, chemical, microbiological, and therapeutic properties throughout its shelf life. Accelerated stability testing and real-time stability testing are…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Overheating Issues in Heat-Sealing Equipment

March 11, 2025 Admin

Addressing Overheating Issues in Heat-Sealing Equipment Addressing Overheating Issues in Heat-Sealing Equipment Introduction: Heat-sealing equipment is pivotal in the pharmaceutical sector, particularly in the packaging of solid dosage forms like tablets. These machines ensure the integrity and safety of pharmaceutical products by creating airtight seals that protect against environmental factors. However, overheating can pose significant…

Solid Dosage form, Tablets

Ensuring Consistency in Tablet Thickness Across Batches

March 11, 2025 Admin

Ensuring Consistency in Tablet Thickness Across Batches Ensuring Consistency in Tablet Thickness Across Batches Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistency of tablet thickness across batches is paramount to maintaining product quality and patient safety. Tablet thickness is not just a matter of aesthetics; it directly correlates with the tablet’s weight, hardness,…

Solid Dosage form, Tablets

Managing Failures in Residual Solvent Control for Purified Water Systems

March 11, 2025 Admin

Managing Failures in Residual Solvent Control for Purified Water Systems Managing Failures in Residual Solvent Control for Purified Water Systems Introduction: The pharmaceutical industry heavily relies on purified water systems to ensure the quality and efficacy of its products. As such, managing residual solvents in these systems is critical for maintaining product safety and compliance…

Solid Dosage form, Tablets

Addressing Deviations in Process Validation for Sugar-Coated Tablets

March 11, 2025 Admin

Addressing Deviations in Process Validation for Sugar-Coated Tablets Addressing Deviations in Process Validation for Sugar-Coated Tablets Introduction: The pharmaceutical industry continuously strives for excellence in manufacturing practices, ensuring product quality and compliance with stringent regulations. Among various dosage forms, sugar-coated tablets remain a staple due to their ability to mask unpleasant tastes and enhance the…

Solid Dosage form, Tablets

Ensuring Consistent Layer Adhesion in Multi-Layer Tablet Compression

March 10, 2025 Admin

Ensuring Consistent Layer Adhesion in Multi-Layer Tablet Compression Ensuring Consistent Layer Adhesion in Multi-Layer Tablet Compression Introduction: In the realm of pharmaceutical manufacturing, multi-layer tablets offer significant benefits, including controlled release, enhanced stability, and the ability to combine incompatible drugs. However, the process of compressing these tablets comes with its own set of challenges, notably…

Solid Dosage form, Tablets

Resolving Failures in Disintegration Testing for High-Dose Tablets

March 10, 2025 Admin

Resolving Failures in Disintegration Testing for High-Dose Tablets Resolving Failures in Disintegration Testing for High-Dose Tablets Introduction: In the pharmaceutical industry, the production of high-dose tablets is a critical process that requires rigorous quality control measures to ensure efficacy and safety. Disintegration testing serves as a cornerstone in evaluating the performance of these tablets, as…

Solid Dosage form, Tablets

Identifying Root Causes of Capping in Compression Stages

March 10, 2025 Admin

Identifying Root Causes of Capping in Compression Stages Identifying Root Causes of Capping in Compression Stages Introduction: In the pharmaceutical industry, the compression stage of tablet manufacturing is crucial. It is during this stage that granulated material is transformed into tablets of uniform size and dosage. However, this process is not without its challenges. One…

Solid Dosage form, Tablets

Inadequate validation of capsule performance under UV light exposure.

March 10, 2025 Admin

Inadequate validation of capsule performance under UV light exposure. Inadequate validation of capsule performance under UV light exposure. Introduction: The pharmaceutical industry is tasked with ensuring the safety, efficacy, and stability of its products. Among the multitude of factors that can affect drug stability, exposure to ultraviolet (UV) light is a significant concern, particularly for…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms