Tag: pharmaceutical quality control

Ensuring Consistency in Binder Addition During Wet Granulation Validation

Posted on By Admin

Ensuring Consistency in Binder Addition During Wet Granulation Validation Ensuring Consistency in Binder Addition During Wet Granulation Validation Introduction: In the world of pharmaceutical manufacturing, wet granulation remains a cornerstone technique for producing tablets. The process involves the addition of a binder solution to the powder mix to form granules, which are then compressed to…

Read More “Ensuring Consistency in Binder Addition During Wet Granulation Validation” »

Solid Dosage form, Tablets

Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time

Posted on By Admin

Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time Introduction: Sugar-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their ability to mask unpleasant tastes and improve patient compliance. However, maintaining the potency of the Active Pharmaceutical Ingredient (API)…

Read More “Troubleshooting Loss of API Potency in Sugar-Coated Tablets Over Time” »

Solid Dosage form, Tablets

Problems with testing capsules containing high API load.

Posted on By Admin

Problems with testing capsules containing high API load. Problems with testing capsules containing high API load. Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form due to their versatility and ease of administration. As the demand for high-dose medications increases, the challenge of creating capsules with a high Active Pharmaceutical Ingredient…

Read More “Problems with testing capsules containing high API load.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Investigating Core Erosion in Extended Release Tablets During Stability Storage

Posted on By Admin

Investigating Core Erosion in Extended Release Tablets During Stability Storage Investigating Core Erosion in Extended Release Tablets During Stability Storage Introduction: In the realm of pharmaceutical development, extended release (ER) tablets play a pivotal role in ensuring patient compliance and therapeutic efficacy. These tablets are designed to release active pharmaceutical ingredients (APIs) at a controlled…

Read More “Investigating Core Erosion in Extended Release Tablets During Stability Storage” »

Solid Dosage form, Tablets

Inadequate validation of capsule disintegration profiles for multi-particulate capsules.

Posted on By Admin

Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Introduction: In the pharmaceutical industry, the validation of capsule disintegration profiles is a critical aspect of ensuring drug efficacy and patient safety. This is particularly important for multi-particulate capsules, which can offer benefits such as improved bioavailability…

Read More “Inadequate validation of capsule disintegration profiles for multi-particulate capsules.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining consistent dissolution profiles over the product’s shelf life.

Posted on By Admin

Problems with maintaining consistent dissolution profiles over the product’s shelf life. Problems with maintaining consistent dissolution profiles over the product’s shelf life. Introduction: The dissolution profile of a pharmaceutical product is a critical parameter that impacts its efficacy and safety. Consistency in dissolution profiles over the product’s shelf life ensures that the drug is released…

Read More “Problems with maintaining consistent dissolution profiles over the product’s shelf life.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in monitoring the weight of individual capsule packs.

Posted on By Admin

Difficulty in monitoring the weight of individual capsule packs. Difficulty in Monitoring the Weight of Individual Capsule Packs Introduction: In the pharmaceutical industry, ensuring the correct weight of individual capsule packs is crucial for maintaining quality control, regulatory compliance, and patient safety. Capsules, whether hard or soft gelatin, are a popular form of solid oral…

Read More “Difficulty in monitoring the weight of individual capsule packs.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Impact of Oxidative Stress on Sugar-Coated Tablets

Posted on By Admin

Addressing Impact of Oxidative Stress on Sugar-Coated Tablets Addressing Impact of Oxidative Stress on Sugar-Coated Tablets Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Among the various solid dosage forms, sugar-coated tablets offer unique benefits such as taste masking and protection of active ingredients. However, these…

Read More “Addressing Impact of Oxidative Stress on Sugar-Coated Tablets” »

Solid Dosage form, Tablets

Inadequate systems for detecting uneven capsule fill levels.

Posted on By Admin

Inadequate systems for detecting uneven capsule fill levels. Inadequate systems for detecting uneven capsule fill levels. Introduction: The pharmaceutical industry is characterized by stringent quality standards, especially concerning solid oral dosage forms like capsules. Ensuring consistent fill levels in capsules is crucial for maintaining therapeutic efficacy, patient safety, and regulatory compliance. However, the systems in…

Read More “Inadequate systems for detecting uneven capsule fill levels.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Consistency in Hardness Testing Across Tablet Batches

Posted on By Admin

Ensuring Consistency in Hardness Testing Across Tablet Batches Ensuring Consistency in Hardness Testing Across Tablet Batches Introduction: In the pharmaceutical industry, ensuring the consistency and quality of tablet batches is paramount. Among the various quality attributes, hardness is a critical parameter that significantly impacts the tablet’s integrity, disintegration, and dissolution profiles. Inconsistencies in hardness can…

Read More “Ensuring Consistency in Hardness Testing Across Tablet Batches” »

Solid Dosage form, Tablets

Difficulty in implementing real-time quality monitoring systems.

Posted on By Admin

Difficulty in implementing real-time quality monitoring systems. Difficulty in Implementing Real-Time Quality Monitoring Systems Introduction: In the pharmaceutical industry, maintaining high standards of product quality is of paramount importance. The advent of real-time quality monitoring systems presents an opportunity to enhance product consistency and ensure compliance with stringent regulatory requirements. These systems allow for continuous…

Read More “Difficulty in implementing real-time quality monitoring systems.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in preventing capsule discoloration during vacuum packaging.

Posted on By Admin

Difficulty in preventing capsule discoloration during vacuum packaging. Difficulty in Preventing Capsule Discoloration During Vacuum Packaging Introduction: Capsule discoloration during vacuum packaging is a persistent challenge faced by pharmaceutical manufacturers. This phenomenon not only affects the aesthetic value of the product but can also indicate compromised product stability. Maintaining the integrity and appearance of capsules…

Read More “Difficulty in preventing capsule discoloration during vacuum packaging.” »

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms