Tag: pharmaceutical quality control

Difficulty in preventing dust contamination during the packing process.

April 25, 2025 Admin

Difficulty in preventing dust contamination during the packing process. Difficulty in Preventing Dust Contamination During the Packing Process Introduction: In the realm of pharmaceutical manufacturing, ensuring the integrity and safety of products is paramount. This is especially true in the case of solid oral dosage forms such as capsules. Among the numerous challenges faced in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with detecting minor defects in capsule shells during stability studies.

April 25, 2025 Admin

Problems with detecting minor defects in capsule shells during stability studies. Problems with detecting minor defects in capsule shells during stability studies. Introduction: In the pharmaceutical industry, ensuring the integrity of solid oral dosage forms, such as capsules, is crucial for maintaining drug efficacy and safety. Capsules, whether hard or soft gelatin, serve as a…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in monitoring capsule sealing temperature for soft gelatin capsules.

April 24, 2025 Admin

Challenges in monitoring capsule sealing temperature for soft gelatin capsules. Challenges in monitoring capsule sealing temperature for soft gelatin capsules. Introduction: Soft gelatin capsules, often referred to as softgels, are a popular dosage form in the pharmaceutical industry due to their ability to encapsulate a wide range of liquid and semi-liquid formulations. The integrity and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor correlation between in vitro dissolution and stability data.

April 24, 2025 Admin

Poor correlation between in vitro dissolution and stability data. Poor correlation between in vitro dissolution and stability data. Introduction: In the pharmaceutical industry, the correlation between in vitro dissolution and stability data is pivotal for ensuring the efficacy and safety of solid oral dosage forms, particularly capsules. Dissolution testing is a key quality control measure…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating sealing equipment for oil-filled capsules.

April 23, 2025 Admin

Challenges in validating sealing equipment for oil-filled capsules. Challenges in validating sealing equipment for oil-filled capsules Introduction: In the pharmaceutical industry, the encapsulation process is critical, particularly when it involves oil-filled capsules. These capsules are essential for delivering hydrophobic compounds and essential oils that do not mix well with water. Ensuring the integrity of these…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule sealing for high-viscosity formulations.

April 23, 2025 Admin

Difficulty in validating capsule sealing for high-viscosity formulations. Difficulty in Validating Capsule Sealing for High-Viscosity Formulations Introduction: In the pharmaceutical industry, the development and manufacturing of solid oral dosage forms, specifically capsules, play a crucial role in delivering medications effectively to patients. Capsules, particularly those filled with high-viscosity formulations, present unique challenges in sealing validation….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring cross-linking in gelatin shells.

April 23, 2025 Admin

Inadequate systems for monitoring cross-linking in gelatin shells. Inadequate Systems for Monitoring Cross-Linking in Gelatin Shells Introduction: In the pharmaceutical industry, gelatin capsules are a popular choice for encapsulating a wide range of medications due to their ease of use, consumer preference, and bioavailability. However, one of the critical quality concerns associated with gelatin capsules,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring consistent capsule appearance across validation batches.

April 23, 2025 Admin

Difficulty in ensuring consistent capsule appearance across validation batches. Difficulty in ensuring consistent capsule appearance across validation batches Introduction: In the pharmaceutical industry, ensuring the consistent appearance of capsules across validation batches is pivotal for maintaining product quality and consumer trust. Capsules, whether hard or soft gelatin, must meet stringent aesthetic standards to ensure they…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in evaluating the stability of multi-particulate capsules.

April 23, 2025 Admin

Difficulty in evaluating the stability of multi-particulate capsules. Difficulty in evaluating the stability of multi-particulate capsules Introduction: In the pharmaceutical industry, ensuring the stability of drug products is crucial for maintaining their efficacy, safety, and quality over their shelf life. Multi-particulate capsules, which contain numerous small, discrete particles within a single dosage form, offer several…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Air Entrapment in Strip Packaging Machines

April 22, 2025 Admin

Addressing Air Entrapment in Strip Packaging Machines Addressing Air Entrapment in Strip Packaging Machines Introduction: In the pharmaceutical industry, strip packaging machines play a critical role in ensuring the protection and integrity of solid dosage forms like tablets. However, air entrapment during the packaging process can compromise product quality and shelf life. Understanding how to…

Solid Dosage form, Tablets

Inadequate systems for validating capsule hardness testing equipment.

April 21, 2025 Admin

Inadequate systems for validating capsule hardness testing equipment. Inadequate systems for validating capsule hardness testing equipment. Introduction: The pharmaceutical industry demands rigorous quality control measures to ensure the safety and efficacy of its products. Among these measures, validating equipment used for testing the hardness of capsules is crucial. Capsule hardness is an essential parameter that…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Conveyor Belt Variations in Blister Packaging Operations

April 21, 2025 Admin

Managing Conveyor Belt Variations in Blister Packaging Operations Managing Conveyor Belt Variations in Blister Packaging Operations Introduction: In the pharmaceutical industry, the packaging process is a critical component that ensures the safety, efficacy, and quality of the final product. Among the various packaging methods, blister packaging stands out due to its ability to provide product…

Solid Dosage form, Tablets