Tag: pharmaceutical guidelines

Investigating Root Causes of Hardness Variability in Coated Tablets

March 31, 2025 Admin

Investigating Root Causes of Hardness Variability in Coated Tablets Investigating Root Causes of Hardness Variability in Coated Tablets Introduction: The pharmaceutical industry is committed to ensuring the quality, efficacy, and safety of its products. Among the various dosage forms, coated tablets are one of the most commonly used due to their convenience, stability, and ease…

Solid Dosage form, Tablets

Troubleshooting Failures in Stability Testing for Film-Coated Tablets

March 30, 2025 Admin

Troubleshooting Failures in Stability Testing for Film-Coated Tablets Troubleshooting Failures in Stability Testing for Film-Coated Tablets Introduction: Stability testing is a critical component in the lifecycle of any pharmaceutical product, especially for film-coated tablets. These tests ensure that the product maintains its intended efficacy, safety, and quality throughout its shelf life. Stability testing evaluates how…

Solid Dosage form, Tablets

Managing Over-Compression in Tablets Prone to Brittleness

March 30, 2025 Admin

Managing Over-Compression in Tablets Prone to Brittleness Managing Over-Compression in Tablets Prone to Brittleness Introduction: In the pharmaceutical industry, tablet formulation and manufacturing are critical processes that ensure medication efficacy and patient safety. Among the numerous challenges faced in tablet production, managing over-compression in tablets prone to brittleness stands out. Over-compression can lead to brittle…

Solid Dosage form, Tablets

Ensuring Consistency in Batch-to-Batch Content Uniformity for Tablets

March 30, 2025 Admin

Ensuring Consistency in Batch-to-Batch Content Uniformity for Tablets Ensuring Consistency in Batch-to-Batch Content Uniformity for Tablets Introduction: In the pharmaceutical industry, ensuring consistency in batch-to-batch content uniformity of tablets is paramount. Content uniformity is crucial for maintaining the safety and efficacy of medications. Variability in the active pharmaceutical ingredient (API) distribution can lead to suboptimal…

Solid Dosage form, Tablets

Preventing Core Damage in Sugar-Coated Tablets During Handling

March 29, 2025 Admin

Preventing Core Damage in Sugar-Coated Tablets During Handling Preventing Core Damage in Sugar-Coated Tablets During Handling Introduction: Sugar-coated tablets are a popular dosage form in the pharmaceutical industry due to their aesthetic appeal, taste masking, and ease of swallowing. However, these advantages can be compromised by core damage during handling. Core damage can lead to…

Solid Dosage form, Tablets

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Consistency in API Release Profiles for Controlled Release Tablets

March 26, 2025 Admin

Ensuring Consistency in API Release Profiles for Controlled Release Tablets Ensuring Consistency in API Release Profiles for Controlled Release Tablets Introduction: In the world of pharmaceuticals, controlled release tablets play a pivotal role in ensuring the therapeutic efficacy of drugs. These formulations are designed to release active pharmaceutical ingredients (APIs) at a predetermined rate, maintaining…

Solid Dosage form, Tablets

Troubleshooting Dissolution Failures in Enteric-Coated Tablets

March 24, 2025 Admin

Troubleshooting Dissolution Failures in Enteric-Coated Tablets Troubleshooting Dissolution Failures in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to bypass the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This coating is crucial for drugs that can be degraded by stomach acid or can…

Solid Dosage form, Tablets

Addressing Over-Lubrication in Powder Mixtures for Blending

March 21, 2025 Admin

Addressing Over-Lubrication in Powder Mixtures for Blending Addressing Over-Lubrication in Powder Mixtures for Blending Introduction: In the pharmaceutical industry, the formulation of solid dosage forms like tablets is a finely tuned process that requires precision and careful consideration of multiple variables. Among these, the use of lubricants in powder mixtures for blending is crucial to…

Solid Dosage form, Tablets

Controlling Weight Variation Across Tablet Batches

March 21, 2025 Admin

Controlling Weight Variation Across Tablet Batches Controlling Weight Variation Across Tablet Batches Introduction: In the pharmaceutical industry, ensuring the uniformity and consistency of tablets is of paramount importance. Weight variation across tablet batches can significantly impact the therapeutic efficacy and safety of a medication. Variations can lead to dosage inconsistencies, which may result in suboptimal…

Solid Dosage form, Tablets

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets

March 20, 2025 Admin

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Introduction: In the pharmaceutical industry, stability studies play a crucial role in ensuring the efficacy, safety, and quality of drug products. For film-coated tablets, stability studies are essential to evaluate how the product maintains its intended physical, chemical, microbiological,…

Solid Dosage form, Tablets

Addressing Core Crumbling in Multi-Layer Tablet Compression

March 20, 2025 Admin

Addressing Core Crumbling in Multi-Layer Tablet Compression Addressing Core Crumbling in Multi-Layer Tablet Compression Introduction: The pharmaceutical industry constantly strives to improve the quality and efficacy of solid dosage forms, particularly tablets. Multi-layer tablets have gained popularity due to their ability to deliver more than one active ingredient with different release profiles. However, the manufacturing…

Solid Dosage form, Tablets