Tag: pharmaceutical formulation

Managing Tablet Core Erosion in Enteric-Coated Tablets

March 21, 2025 Admin

Managing Tablet Core Erosion in Enteric-Coated Tablets Managing Tablet Core Erosion in Enteric-Coated Tablets Introduction: Enteric-coated tablets represent a sophisticated drug delivery system designed to bypass the acidic environment of the stomach and to release their active ingredients in the more neutral pH of the intestines. This method of delivery is essential for drugs that…

Solid Dosage form, Tablets

Managing Surface Roughness in Sugar-Coated Tablets After Stability Storage

March 20, 2025 Admin

Managing Surface Roughness in Sugar-Coated Tablets After Stability Storage Managing Surface Roughness in Sugar-Coated Tablets After Stability Storage Introduction: Sugar-coated tablets remain a popular choice in the pharmaceutical industry due to their aesthetic appeal and ability to mask unpleasant tastes. However, maintaining their quality over time, especially during stability storage, presents challenges such as surface…

Solid Dosage form, Tablets

Addressing Over-Sensitivity to Humidity in Hygroscopic Tablets

March 19, 2025 Admin

Addressing Over-Sensitivity to Humidity in Hygroscopic Tablets Addressing Over-Sensitivity to Humidity in Hygroscopic Tablets Introduction: In the pharmaceutical industry, the stability of solid dosage forms like tablets is paramount to ensuring efficacy and safety. Hygroscopic tablets, which readily absorb moisture from their environment, present unique challenges in terms of formulation, manufacturing, and storage. Over-sensitivity to…

Solid Dosage form, Tablets

Challenges in maintaining uniform mixing of multi-component powder blends.

March 19, 2025 Admin

Challenges in maintaining uniform mixing of multi-component powder blends. Challenges in maintaining uniform mixing of multi-component powder blends. Introduction: In the pharmaceutical industry, ensuring the uniform mixing of multi-component powder blends is crucial for the efficacy and safety of solid oral dosage forms, such as capsules. Uniformity in blending impacts the quality and consistency of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Over-Compression in Tablets with High-Dose APIs

March 18, 2025 Admin

Managing Over-Compression in Tablets with High-Dose APIs Managing Over-Compression in Tablets with High-Dose APIs Introduction: The pharmaceutical industry is increasingly challenged with the development and manufacturing of tablets that contain high-dose Active Pharmaceutical Ingredients (APIs). While these tablets are crucial for ensuring therapeutic efficacy, they come with a unique set of challenges, particularly in terms…

Solid Dosage form, Tablets

Identifying Causes of Tablet Swelling During Disintegration Testing

March 17, 2025 Admin

Identifying Causes of Tablet Swelling During Disintegration Testing Identifying Causes of Tablet Swelling During Disintegration Testing Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms, such as tablets, is paramount. A critical aspect of this quality control is disintegration testing, a process that evaluates how quickly a tablet breaks down…

Solid Dosage form, Tablets

Achieving Uniform Blend Distribution in Blending Machines

March 17, 2025 Admin

Achieving Uniform Blend Distribution in Blending Machines Achieving Uniform Blend Distribution in Blending Machines Introduction: In the pharmaceutical industry, ensuring the uniform distribution of active pharmaceutical ingredients (APIs) and excipients in solid dosage forms is critical for product efficacy, safety, and quality. Blending is a key process in tablet manufacturing, where achieving uniform blend distribution…

Solid Dosage form, Tablets

Managing Variability in Dissolution Testing for Immediate Release Tablets

March 16, 2025 Admin

Managing Variability in Dissolution Testing for Immediate Release Tablets Managing Variability in Dissolution Testing for Immediate Release Tablets Introduction: Dissolution testing is a critical quality control measure in the pharmaceutical industry, particularly for immediate release tablets. This test ensures that the tablet releases its active ingredients at the desired rate and extent, which is crucial…

Solid Dosage form, Tablets

Managing Failures in Weight Uniformity Tests for High-Speed Compression

March 15, 2025 Admin

Managing Failures in Weight Uniformity Tests for High-Speed Compression Managing Failures in Weight Uniformity Tests for High-Speed Compression Introduction: The pharmaceutical industry is ever-evolving, with the demand for high-quality and efficient production processes constantly on the rise. High-speed compression in tablet manufacturing is a critical process, crucial for meeting market demands and ensuring patient safety….

Solid Dosage form, Tablets

Troubleshooting Non-Adherence of Coating Materials in Enteric Tablets

March 13, 2025 Admin

Troubleshooting Non-Adherence of Coating Materials in Enteric Tablets Troubleshooting Non-Adherence of Coating Materials in Enteric Tablets Introduction: Enteric tablets are specially designed solid dosage forms that remain intact in the acidic environment of the stomach and dissolve in the more neutral pH of the intestine. This ensures that active pharmaceutical ingredients (APIs) are released at…

Solid Dosage form, Tablets

High variability in stability data for oil-filled capsules.

March 12, 2025 Admin

High variability in stability data for oil-filled capsules. High variability in stability data for oil-filled capsules. Introduction: In the pharmaceutical industry, maintaining the stability of medicinal products is crucial to ensure their safety, efficacy, and quality over their shelf life. Among various dosage forms, oil-filled capsules—encompassing both hard and soft gelatin variants—present unique challenges in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Failures in Moisture Content Tests for Hygroscopic APIs

March 11, 2025 Admin

Managing Failures in Moisture Content Tests for Hygroscopic APIs Managing Failures in Moisture Content Tests for Hygroscopic APIs Introduction: In the pharmaceutical industry, Active Pharmaceutical Ingredients (APIs) form the backbone of drug manufacturing. Among these, hygroscopic APIs present unique challenges due to their inherent ability to absorb moisture from the environment. Accurate moisture content testing…

Solid Dosage form, Tablets