Tag: pharmaceutical formulation

Challenges in ensuring consistent capsule coating thickness during validation.

April 16, 2025 Admin

Challenges in ensuring consistent capsule coating thickness during validation. Challenges in ensuring consistent capsule coating thickness during validation. Introduction: In the pharmaceutical industry, capsules are a prevalent solid oral dosage form due to their ease of administration and ability to deliver precise dosages. Both hard and soft gelatin capsules can be coated for various reasons…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent fill weight for semi-solid formulations.

April 14, 2025 Admin

Problems with ensuring consistent fill weight for semi-solid formulations. Problems with Ensuring Consistent Fill Weight for Semi-Solid Formulations Introduction: In the pharmaceutical industry, maintaining consistent fill weight in semi-solid formulations is crucial for ensuring product efficacy, safety, and regulatory compliance. Semi-solid formulations, often used in capsules, pose unique challenges due to their complex nature. Ensuring…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High variability in the thickness of blister foil materials.

April 14, 2025 Admin

High variability in the thickness of blister foil materials. High Variability in the Thickness of Blister Foil Materials Introduction: Blister packaging is a critical component in the pharmaceutical industry, offering protection and extended shelf life for solid oral dosage forms like capsules and tablets. However, variability in the thickness of blister foil materials can pose…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with testing capsules containing high API load.

April 13, 2025 Admin

Problems with testing capsules containing high API load. Problems with testing capsules containing high API load. Introduction: In the pharmaceutical industry, capsules are a popular solid oral dosage form due to their versatility and ease of administration. As the demand for high-dose medications increases, the challenge of creating capsules with a high Active Pharmaceutical Ingredient…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Investigating Core Erosion in Extended Release Tablets During Stability Storage

April 13, 2025 Admin

Investigating Core Erosion in Extended Release Tablets During Stability Storage Investigating Core Erosion in Extended Release Tablets During Stability Storage Introduction: In the realm of pharmaceutical development, extended release (ER) tablets play a pivotal role in ensuring patient compliance and therapeutic efficacy. These tablets are designed to release active pharmaceutical ingredients (APIs) at a controlled…

Solid Dosage form, Tablets

Difficulty in evaluating the impact of excipient changes on capsule stability.

April 12, 2025 Admin

Difficulty in evaluating the impact of excipient changes on capsule stability. Difficulty in Evaluating the Impact of Excipient Changes on Capsule Stability Introduction: In the pharmaceutical industry, the stability of a drug product is a critical factor that influences its safety, efficacy, and shelf-life. Capsules, both hard and soft gelatin, are popular solid oral dosage…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring consistent gelatin solution viscosity during production.

April 9, 2025 Admin

Difficulty in ensuring consistent gelatin solution viscosity during production. Difficulty in Ensuring Consistent Gelatin Solution Viscosity During Production Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistent viscosity of gelatin solutions is paramount for producing high-quality capsules, both hard and soft gelatin types. Gelatin serves as a critical component in encapsulation, providing the structural…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with bioequivalence requirements for capsules.

April 9, 2025 Admin

Difficulty in ensuring compliance with bioequivalence requirements for capsules. Difficulty in ensuring compliance with bioequivalence requirements for capsules. Introduction: In the pharmaceutical industry, ensuring that generic formulations are bioequivalent to their branded counterparts is crucial. Bioequivalence ensures that a generic drug releases its active ingredient into the bloodstream at the same rate and level as…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Validating Coating Thickness Consistency Across Batch Sizes

April 8, 2025 Admin

Validating Coating Thickness Consistency Across Batch Sizes Validating Coating Thickness Consistency Across Batch Sizes Introduction: The pharmaceutical industry places significant emphasis on the quality and consistency of solid dosage forms, particularly tablets. Among the various quality attributes, coating thickness is crucial, influencing not just appearance, but also the release profile, stability, and overall efficacy of…

Solid Dosage form, Tablets

Problems with achieving consistent shell thickness for multi-particulate capsules.

April 8, 2025 Admin

Problems with achieving consistent shell thickness for multi-particulate capsules. Problems with achieving consistent shell thickness for multi-particulate capsules. Introduction: In the pharmaceutical industry, the production of multi-particulate capsules has become increasingly significant due to their advantages in controlled drug release and patient compliance. However, achieving consistent shell thickness in these capsules is crucial for ensuring…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with predicting the stability of capsules containing sensitive APIs.

April 6, 2025 Admin

Problems with predicting the stability of capsules containing sensitive APIs. Problems with Predicting the Stability of Capsules Containing Sensitive APIs Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount to maintaining efficacy and safety throughout their shelf life. Capsules, both hard and soft gelatin, are popular dosage forms due to their…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor adhesion of tamper-evident seals to capsule containers.

April 4, 2025 Admin

Poor adhesion of tamper-evident seals to capsule containers. Poor adhesion of tamper-evident seals to capsule containers. Introduction: The pharmaceutical industry places a high premium on ensuring the safety and integrity of its products, and tamper-evident packaging plays a crucial role in achieving this goal. Tamper-evident seals on capsule containers provide a visual indication of product…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms