Tag: pharmaceutical formulation

Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets

June 2, 2025 Admin

Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets Introduction: In the pharmaceutical industry, multi-layer tablets are gaining prominence due to their ability to deliver multiple drugs or achieve controlled release profiles. However, these complex formulations often face challenges, particularly with the adherence of coating layers. Ensuring that…

Solid Dosage form, Tablets

Troubleshooting Over-Lubrication in Powder Blends During Compression Validation

June 1, 2025 Admin

Troubleshooting Over-Lubrication in Powder Blends During Compression Validation Troubleshooting Over-Lubrication in Powder Blends During Compression Validation Introduction: In the pharmaceutical industry, the production of tablets is a complex process that demands precision and careful attention to detail. One critical aspect of tablet manufacturing is the lubrication of powder blends, which facilitates the tablet compression process….

Solid Dosage form, Tablets

Preventing Color Fading in Sugar-Coated Tablets During Packaging

June 1, 2025 Admin

Preventing Color Fading in Sugar-Coated Tablets During Packaging Preventing Color Fading in Sugar-Coated Tablets During Packaging Introduction: Sugar-coated tablets have been a staple in the pharmaceutical industry, providing an effective way to mask the taste of medication while enhancing its aesthetic appeal. However, maintaining the vibrant color of these tablets during packaging and storage is…

Solid Dosage form, Tablets

Investigating Impact of Humidity on Coating Integrity in Film-Coated Tablets

May 31, 2025 Admin

Investigating Impact of Humidity on Coating Integrity in Film-Coated Tablets Investigating Impact of Humidity on Coating Integrity in Film-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the integrity of film-coated tablets is a critical aspect of product quality and efficacy. Film coatings on tablets serve multiple purposes, including protection from environmental factors, masking unpleasant tastes,…

Solid Dosage form, Tablets

Ensuring Consistent Release Profiles in Multi-API Tablets Over Time

May 27, 2025 Admin

Ensuring Consistent Release Profiles in Multi-API Tablets Over Time Ensuring Consistent Release Profiles in Multi-API Tablets Over Time Introduction: In the pharmaceutical industry, the formulation and manufacturing of multi-API (Active Pharmaceutical Ingredient) tablets present a complex challenge. Ensuring consistent drug release profiles over time is crucial for therapeutic efficacy and patient safety. A consistent release…

Solid Dosage form, Tablets

Addressing Non-Uniform Granule Size in Fluid Bed Granulators During Validation

May 20, 2025 Admin

Addressing Non-Uniform Granule Size in Fluid Bed Granulators During Validation Addressing Non-Uniform Granule Size in Fluid Bed Granulators During Validation Introduction: In the pharmaceutical industry, maintaining consistent granule size during the fluid bed granulation process is crucial for ensuring the quality and efficacy of solid dosage forms like tablets. Granule size uniformity affects the flow…

Solid Dosage form, Tablets

Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing

May 19, 2025 Admin

Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing Introduction: In the pharmaceutical industry, multi-layer tablets have become a sophisticated option for delivering multiple active pharmaceutical ingredients (APIs) with distinct release profiles. These tablets offer numerous advantages, including improved patient compliance and efficient dosing schedules. However,…

Solid Dosage form, Tablets

Managing Brittleness in High-Dose Tablets Under Stability Conditions

May 11, 2025 Admin

Managing Brittleness in High-Dose Tablets Under Stability Conditions Managing Brittleness in High-Dose Tablets Under Stability Conditions Introduction: In the pharmaceutical industry, the development of high-dose tablets presents several challenges, particularly concerning their brittleness under stability conditions. Brittleness can compromise the efficacy, safety, and quality of the medication, which is crucial for patient health. Understanding and…

Solid Dosage form, Tablets

Investigating API Potency Retention in Immediate Release Tablets Over Time

May 11, 2025 Admin

Investigating API Potency Retention in Immediate Release Tablets Over Time Investigating API Potency Retention in Immediate Release Tablets Over Time Introduction: In the pharmaceutical industry, ensuring the efficacy and safety of medicinal products is paramount. One critical aspect of this is the potency retention of the Active Pharmaceutical Ingredient (API) in immediate release tablets over…

Solid Dosage form, Tablets

Managing API Migration in Multi-API Tablets During Stability Testing

May 11, 2025 Admin

Managing API Migration in Multi-API Tablets During Stability Testing Managing API Migration in Multi-API Tablets During Stability Testing Introduction: In the ever-evolving world of pharmaceuticals, the development of multi-active pharmaceutical ingredient (API) tablets has gained significant momentum. These formulations offer the advantage of delivering multiple therapeutic effects in a single dose, enhancing patient compliance and…

Solid Dosage form, Tablets

Challenges in ensuring consistent gelatin solution pH during production.

May 1, 2025 Admin

Challenges in ensuring consistent gelatin solution pH during production. Challenges in ensuring consistent gelatin solution pH during production. Introduction: In the pharmaceutical industry, the production of capsules, specifically those made of gelatin, is a meticulous process that requires precise control over various parameters. Among these, maintaining a consistent pH level in gelatin solutions is crucial….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in monitoring capsule moisture content during accelerated stability studies.

April 28, 2025 Admin

Difficulty in monitoring capsule moisture content during accelerated stability studies. Difficulty in monitoring capsule moisture content during accelerated stability studies. Introduction: Monitoring the moisture content in capsules during accelerated stability studies is a critical component in the pharmaceutical industry. These studies are essential for predicting the shelf life and ensuring the quality, safety, and efficacy…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms