Tag: Pharmaceutical excipients

Troubleshooting Brittleness in High-Dose Tablets During Compression Validation

May 17, 2025 Admin

Troubleshooting Brittleness in High-Dose Tablets During Compression Validation Troubleshooting Brittleness in High-Dose Tablets During Compression Validation Introduction: In the pharmaceutical industry, tablet formulation and manufacturing represent critical processes that significantly impact the quality, efficacy, and safety of the final product. High-dose tablets are particularly challenging to develop due to the increased risks of brittleness, which…

Solid Dosage form, Tablets

Difficulty in assessing stability of capsules containing hygroscopic excipients.

March 28, 2025 Admin

Difficulty in assessing stability of capsules containing hygroscopic excipients. Difficulty in Assessing Stability of Capsules Containing Hygroscopic Excipients Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and patient compliance. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Over-Lubrication Issues in Immediate Release Tablets

March 14, 2025 Admin

Resolving Over-Lubrication Issues in Immediate Release Tablets Resolving Over-Lubrication Issues in Immediate Release Tablets Introduction: Immediate release tablets are a mainstay in the pharmaceutical industry, offering quick onset of action and ease of administration. However, the formulation and manufacturing of these tablets present unique challenges, particularly with lubrication. Over-lubrication can compromise tablet quality, affecting disintegration…

Solid Dosage form, Tablets

What are the challenges in manufacturing capsules with highly potent APIs?

August 11, 2023July 31, 2023 Admin

Challenges in Manufacturing Capsules with Highly Potent APIs Manufacturing capsules with highly potent active pharmaceutical ingredients (APIs) presents unique challenges due to the increased risk associated with handling and processing these potent compounds. Highly potent APIs are those that have a pharmacological activity at very low doses, often in the microgram or even nanogram range….

Capsules (Hard & Soft Gelatin)

How are capsule formulations developed for pediatric use?

August 10, 2023July 31, 2023 Admin

Development of Capsule Formulations for Pediatric Use Developing capsule formulations for pediatric use requires careful consideration of various factors to ensure the safety, efficacy, and acceptability of the medication for children. Pediatric formulations need to be age-appropriate, easy to administer, and palatable. Here’s a step-by-step guide to the development of capsule formulations for pediatric use:…

Capsules (Hard & Soft Gelatin)

How are injectables formulated for targeted drug delivery?

August 9, 2023August 2, 2023 Admin

Formulation Strategies for Targeted Drug Delivery in Injectables Targeted drug delivery in injectables aims to deliver medications selectively to specific tissues or cells while minimizing systemic exposure and reducing side effects. To achieve targeted drug delivery, various formulation strategies are employed in injectable products. Here are some common approaches: 1. Nanoparticles and Liposomes Nanoparticles and…

Parenteral Drug Manufacturing

What are the different types of capsule filling machines used in the industry?

August 9, 2023July 31, 2023 Admin

Different Types of Capsule Filling Machines Used in the Industry Capsule filling machines are essential equipment in the pharmaceutical industry for filling empty capsules with active pharmaceutical ingredients (APIs) and other formulations. Different types of capsule filling machines are available, each designed to meet specific production requirements and capsule sizes. Here are the main types…

Capsules (Hard & Soft Gelatin)

What are the challenges in manufacturing biodegradable injectable products?

August 8, 2023August 2, 2023 Admin

Challenges in Manufacturing Biodegradable Injectable Products Biodegradable injectable products are pharmaceutical formulations designed to degrade over time in the body, reducing the need for removal or extraction after their therapeutic effects have been achieved. While these products offer significant benefits, there are several challenges in their manufacturing process. Here are some key challenges in manufacturing…

Parenteral Drug Manufacturing

How is the uniformity of fill weight ensured during capsule production?

August 8, 2023July 31, 2023 Admin

Ensuring Uniformity of Fill Weight During Capsule Production Maintaining the uniformity of fill weight is a critical aspect of capsule production to ensure that each capsule contains the correct and consistent amount of the active pharmaceutical ingredient (API) or formulation. Variability in fill weight can lead to dosage inaccuracies and affect the efficacy and safety…

Capsules (Hard & Soft Gelatin)

How are lyophilized injectables reconstituted before administration?

August 7, 2023August 2, 2023 Admin

Reconstitution of Lyophilized Injectables Lyophilized injectables, also known as freeze-dried products, are solid formulations that have been subjected to freeze-drying to remove moisture and improve stability. Before administration, these products need to be reconstituted with a suitable solvent to transform them into a liquid form suitable for injection. Here’s an overview of the reconstitution process…

Parenteral Drug Manufacturing

Explain the role of lubricants in capsule filling.

August 7, 2023July 31, 2023 Admin

Role of Lubricants in Capsule Filling Lubricants play a vital role in capsule filling processes to facilitate smooth and efficient operations. They are added to the formulation to reduce friction and prevent adhesion between the capsule content and the surfaces of the capsule filling equipment. The proper use of lubricants is essential in ensuring consistent…

Capsules (Hard & Soft Gelatin)

What are the key elements of an injectable formulation development process?

August 6, 2023August 2, 2023 Admin

Key Elements of an Injectable Formulation Development Process The development of an injectable formulation is a complex and iterative process that requires careful consideration of various factors. The goal is to create a safe, stable, and effective product that can be administered via injection routes such as intravenous, intramuscular, or subcutaneous. The key elements of…

Parenteral Drug Manufacturing