Tag: pharmaceutical engineering

Identifying Root Causes of Capping in Compression Stages

March 10, 2025 Admin

Identifying Root Causes of Capping in Compression Stages Identifying Root Causes of Capping in Compression Stages Introduction: In the pharmaceutical industry, the compression stage of tablet manufacturing is crucial. It is during this stage that granulated material is transformed into tablets of uniform size and dosage. However, this process is not without its challenges. One…

Solid Dosage form, Tablets

Controlling Powder Flow in Feed Frames for Film-Coated Tablets

March 10, 2025 Admin

Controlling Powder Flow in Feed Frames for Film-Coated Tablets Controlling Powder Flow in Feed Frames for Film-Coated Tablets Introduction: The pharmaceutical industry relies heavily on the production of solid dosage forms, with tablets being one of the most common. Ensuring consistent and reliable production of film-coated tablets requires precise control over several variables, one of…

Solid Dosage form, Tablets

Managing Punch Adhesion Issues in Tablet Press Machines During Validation

March 10, 2025 Admin

Managing Punch Adhesion Issues in Tablet Press Machines During Validation Managing Punch Adhesion Issues in Tablet Press Machines During Validation Introduction: In the pharmaceutical industry, the production of high-quality tablets is crucial for ensuring patient safety and therapeutic efficacy. One of the persistent challenges faced during tablet manufacturing is punch adhesion, commonly referred to as…

Solid Dosage form, Tablets

Real-Time Adjustment of Granulation Parameters for Uniformity

March 9, 2025 Admin

Real-Time Adjustment of Granulation Parameters for Uniformity Real-Time Adjustment of Granulation Parameters for Uniformity Introduction: In the pharmaceutical industry, the uniformity of granulation is critical for ensuring the quality and efficacy of solid dosage forms, particularly tablets. Granulation is a pivotal step in the tablet manufacturing process, where powder particles are aggregated to form granules….

Solid Dosage form, Tablets

Challenges in Binder Addition During Granulation

March 9, 2025 Admin

Challenges in Binder Addition During Granulation Challenges in Binder Addition During Granulation Introduction: In the pharmaceutical industry, granulation is a crucial process in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form larger entities known as granules. One of the most critical components in the granulation…

Solid Dosage form, Tablets

Troubleshooting Residual API Issues in Granulation Vessels Used for Extended Release Tablets

March 9, 2025 Admin

Troubleshooting Residual API Issues in Granulation Vessels Used for Extended Release Tablets Troubleshooting Residual API Issues in Granulation Vessels Used for Extended Release Tablets Introduction: In the pharmaceutical industry, the production of extended release tablets requires precise formulation and meticulous processing to ensure therapeutic efficacy and patient safety. Granulation vessels play a crucial role in…

Solid Dosage form, Tablets

Managing Fines Generation in Fluid Bed Processing

March 9, 2025 Admin

Managing Fines Generation in Fluid Bed Processing Managing Fines Generation in Fluid Bed Processing Introduction: Fluid bed processing is a critical operation in pharmaceutical manufacturing, primarily utilized for drying, granulating, and coating purposes. Its efficiency and effectiveness in producing uniform and quality granules make it a preferred choice in tablet production. However, a persistent challenge…

Solid Dosage form, Tablets

Preventing Core Breakage in Multi-Layer Tablets During Compression

March 8, 2025 Admin

Preventing Core Breakage in Multi-Layer Tablets During Compression Preventing Core Breakage in Multi-Layer Tablets During Compression Introduction: In the pharmaceutical industry, the development of multi-layer tablets offers a strategic approach to deliver multiple active pharmaceutical ingredients (APIs) or to control the release profiles of medications. However, the manufacturing of these complex dosage forms presents unique…

Solid Dosage form, Tablets

Real-Time Monitoring of Spray Uniformity in Coating Processes

March 8, 2025 Admin

Real-Time Monitoring of Spray Uniformity in Coating Processes Real-Time Monitoring of Spray Uniformity in Coating Processes Introduction: In the pharmaceutical industry, the coating process of tablets is a critical step that significantly influences the quality and efficacy of the final product. Ensuring uniformity in spray coating is essential to achieve the desired therapeutic effects, protect…

Solid Dosage form, Tablets

Managing Residual Solvent Contamination in Utility Lines for Coated Tablets

March 8, 2025 Admin

Managing Residual Solvent Contamination in Utility Lines for Coated Tablets Managing Residual Solvent Contamination in Utility Lines for Coated Tablets Introduction: Residual solvent contamination in utility lines presents a significant challenge in the production of coated tablets. These solvents, often used in pharmaceutical manufacturing processes, must be carefully managed to ensure product safety, efficacy, and…

Solid Dosage form, Tablets

Validating Adequacy of Binder Concentration in Wet Granulation Processes

March 8, 2025 Admin

Validating Adequacy of Binder Concentration in Wet Granulation Processes Validating Adequacy of Binder Concentration in Wet Granulation Processes Introduction: In the realm of pharmaceutical manufacturing, the wet granulation process is a cornerstone for producing high-quality tablets. Ensuring the adequacy of binder concentration is critical in this process, as it directly influences the tablet’s integrity, dissolution…

Solid Dosage form, Tablets

Preventing Cracking in Bilayer Tablets During Drying Stages

March 8, 2025 Admin

Preventing Cracking in Bilayer Tablets During Drying Stages Preventing Cracking in Bilayer Tablets During Drying Stages Introduction: Bilayer tablets are an innovative and efficient way to deliver multiple drugs or different release profiles in a single dosage form. They are engineered to provide controlled release, improve patient compliance, and optimize therapeutic outcomes. However, manufacturing bilayer…

Solid Dosage form, Tablets