Tag: pharmaceutical engineering

Difficulty in validating capsule filling processes for multi-layer capsules.

March 16, 2025 Admin

Difficulty in validating capsule filling processes for multi-layer capsules. Difficulty in Validating Capsule Filling Processes for Multi-layer Capsules Introduction: In the ever-evolving pharmaceutical industry, capsule formulations have become a pivotal aspect of oral dosage forms. Multi-layer capsules, offering innovative solutions for drug release, combination therapies, and patient compliance, are gaining popularity. However, the complexity of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Compliance with GMP Standards During Validation of Compression Equipment

March 16, 2025 Admin

Ensuring Compliance with GMP Standards During Validation of Compression Equipment Ensuring Compliance with GMP Standards During Validation of Compression Equipment Introduction: In the pharmaceutical industry, compliance with Good Manufacturing Practice (GMP) standards is paramount to ensure the safety and efficacy of drug products. The validation of compression equipment, an essential process in tablet production, is…

Solid Dosage form, Tablets

Troubleshooting Static Charge in Powder Handling Systems

March 16, 2025 Admin

Troubleshooting Static Charge in Powder Handling Systems Troubleshooting Static Charge in Powder Handling Systems Introduction: In the pharmaceutical industry, the handling of powders is a critical step in the production of solid dosage forms, particularly tablets. However, a common and often challenging issue that arises during this process is the buildup of static charge. Static…

Solid Dosage form, Tablets

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets

March 15, 2025 Admin

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Introduction: In the realm of pharmaceutical manufacturing, roller compaction is a critical granulation method frequently employed for the production of large-scale tablets. This process is favored for its ability to handle heat and moisture-sensitive compounds without requiring…

Solid Dosage form, Tablets

Preventing Granule Breakage During Fluid Bed Drying

March 14, 2025 Admin

Preventing Granule Breakage During Fluid Bed Drying Preventing Granule Breakage During Fluid Bed Drying Introduction: In the pharmaceutical industry, fluid bed drying is a critical process in the production of solid dosage forms, particularly tablets. This method is favored for its efficiency in drying granules, which are the intermediate product before compression into tablets. However,…

Solid Dosage form, Tablets

Difficulty in monitoring fill weight uniformity during high-speed production.

March 13, 2025 Admin

Difficulty in monitoring fill weight uniformity during high-speed production. Difficulty in monitoring fill weight uniformity during high-speed production. Introduction: In the pharmaceutical industry, ensuring the uniformity of fill weight in capsule production is crucial for maintaining product quality and efficacy. This becomes increasingly complex during high-speed manufacturing, where rapid production rates can introduce variability. This…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of capsule printing equipment for accuracy at high speeds.

March 12, 2025 Admin

Poor validation of capsule printing equipment for accuracy at high speeds. Poor validation of capsule printing equipment for accuracy at high speeds. Introduction: In the pharmaceutical industry, capsule printing is a critical process that enhances product identification, ensures brand integrity, and aids in ensuring patient safety. With the increasing demand for high-speed manufacturing, the validation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Preventing Tablet Breakage During Blister Sealing for High-Speed Machines

March 12, 2025 Admin

Preventing Tablet Breakage During Blister Sealing for High-Speed Machines Preventing Tablet Breakage During Blister Sealing for High-Speed Machines Introduction: The pharmaceutical industry constantly aims to enhance the efficiency and reliability of drug production, particularly in the area of solid dosage forms like tablets. One critical aspect is the packaging process, where blister sealing plays a…

Solid Dosage form, Tablets

Preventing Tablet Damage During Drop Testing of Blister Packs

March 12, 2025 Admin

Preventing Tablet Damage During Drop Testing of Blister Packs Preventing Tablet Damage During Drop Testing of Blister Packs Introduction: In the pharmaceutical industry, ensuring the integrity of solid dosage forms such as tablets is crucial to maintaining product efficacy and patient safety. Blister packs are a common packaging solution designed to protect tablets from environmental…

Solid Dosage form, Tablets

Preventing Tablet Capping During High-Speed Compression

March 11, 2025 Admin

Preventing Tablet Capping During High-Speed Compression Preventing Tablet Capping During High-Speed Compression Introduction: The pharmaceutical industry is ever-evolving, with technological advancements pushing the boundaries of speed and efficiency in drug manufacturing. Tablets, as a prevalent solid dosage form, are at the forefront of this evolution. However, with high-speed compression, challenges such as tablet capping can…

Solid Dosage form, Tablets

Ensuring Consistent Layer Adhesion in Multi-Layer Tablet Compression

March 10, 2025 Admin

Ensuring Consistent Layer Adhesion in Multi-Layer Tablet Compression Ensuring Consistent Layer Adhesion in Multi-Layer Tablet Compression Introduction: In the realm of pharmaceutical manufacturing, multi-layer tablets offer significant benefits, including controlled release, enhanced stability, and the ability to combine incompatible drugs. However, the process of compressing these tablets comes with its own set of challenges, notably…

Solid Dosage form, Tablets

Identifying Root Causes of Capping in Compression Stages

March 10, 2025 Admin

Identifying Root Causes of Capping in Compression Stages Identifying Root Causes of Capping in Compression Stages Introduction: In the pharmaceutical industry, the compression stage of tablet manufacturing is crucial. It is during this stage that granulated material is transformed into tablets of uniform size and dosage. However, this process is not without its challenges. One…

Solid Dosage form, Tablets