Tag: pharmaceutical development

Inadequate validation of capsule performance under UV light exposure.

March 10, 2025 Admin

Inadequate validation of capsule performance under UV light exposure. Inadequate validation of capsule performance under UV light exposure. Introduction: The pharmaceutical industry is tasked with ensuring the safety, efficacy, and stability of its products. Among the multitude of factors that can affect drug stability, exposure to ultraviolet (UV) light is a significant concern, particularly for…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Validating Adequacy of Binder Distribution in Compression Processes

March 9, 2025 Admin

Validating Adequacy of Binder Distribution in Compression Processes Validating Adequacy of Binder Distribution in Compression Processes Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms such as tablets is paramount. A critical aspect of this is the distribution of binders during the compression process. Binders play a key role in…

Solid Dosage form, Tablets

Ensuring Effective Binder Distribution in Wet Granulation Processes

March 9, 2025 Admin

Ensuring Effective Binder Distribution in Wet Granulation Processes Ensuring Effective Binder Distribution in Wet Granulation Processes Introduction: Wet granulation is a critical process in the production of tablets, fundamentally influencing the quality and efficacy of the final pharmaceutical product. At the heart of the wet granulation process lies the challenge of ensuring effective binder distribution….

Solid Dosage form, Tablets

Challenges in Binder Addition During Granulation

March 9, 2025 Admin

Challenges in Binder Addition During Granulation Challenges in Binder Addition During Granulation Introduction: In the pharmaceutical industry, granulation is a crucial process in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form larger entities known as granules. One of the most critical components in the granulation…

Solid Dosage form, Tablets

Addressing Layer Delamination Issues During Disintegration Testing

March 8, 2025 Admin

Addressing Layer Delamination Issues During Disintegration Testing Addressing Layer Delamination Issues During Disintegration Testing Introduction: In the world of pharmaceuticals, ensuring the integrity of solid dosage forms like tablets is of utmost importance. Layer delamination, a challenge often encountered during disintegration testing, can compromise the efficacy and safety of a pharmaceutical product. This phenomenon occurs…

Solid Dosage form, Tablets

Controlling Binder Distribution in Wet Granulation Processes

March 7, 2025 Admin

Controlling Binder Distribution in Wet Granulation Processes Controlling Binder Distribution in Wet Granulation Processes Introduction: In the pharmaceutical industry, the wet granulation process is a critical method for producing tablets. It involves the agglomeration of powder particles using a liquid binder, which helps improve the flow and compaction properties of the powder mix. However, the…

Solid Dosage form, Tablets

Difficulty in testing for capsule tamper resistance.

March 7, 2025 Admin

Difficulty in testing for capsule tamper resistance. Difficulty in Testing for Capsule Tamper Resistance Introduction: In the pharmaceutical industry, ensuring the integrity and safety of drug products is paramount. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and efficiency in delivering medication. However, they are vulnerable to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in testing gelatin-free capsules for uniformity.

March 7, 2025 Admin

Difficulty in testing gelatin-free capsules for uniformity. Difficulty in Testing Gelatin-Free Capsules for Uniformity Introduction: In the evolving landscape of pharmaceutical formulations, gelatin-free capsules have emerged as a significant advancement, especially for those seeking vegetarian or vegan alternatives. These capsules not only cater to dietary preferences but also overcome some of the limitations associated with…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets

March 7, 2025 Admin

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Introduction: In the pharmaceutical industry, the production of multi-API (Active Pharmaceutical Ingredient) tablets requires precise formulation and meticulous blending to ensure each tablet meets stringent quality standards. Achieving homogeneity in powder blends is crucial for ensuring that every tablet…

Solid Dosage form, Tablets

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing

March 7, 2025 Admin

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Introduction: Coated tablets are a prevalent form of medication delivery in the pharmaceutical industry, designed to improve the stability, appearance, and release characteristics of the active pharmaceutical ingredient (API). The disintegration of these tablets is a critical quality attribute…

Solid Dosage form, Tablets

Addressing API Migration in Bilayer Tablets During Long-Term Testing

March 6, 2025 Admin

Addressing API Migration in Bilayer Tablets During Long-Term Testing Addressing API Migration in Bilayer Tablets During Long-Term Testing Introduction: Bilayer tablets are an innovative pharmaceutical dosage form designed to deliver two different active pharmaceutical ingredients (APIs) or to control the release of a single API over time. However, the process of ensuring the stability and…

Solid Dosage form, Tablets

Addressing High Friability in Sugar-Coated Tablets

March 4, 2025 Admin

Addressing High Friability in Sugar-Coated Tablets Addressing High Friability in Sugar-Coated Tablets Introduction: Sugar-coated tablets are a popular solid dosage form due to their appealing appearance, taste masking capabilities, and ability to protect the drug core from environmental factors. However, achieving the ideal balance between coating thickness and tablet robustness is crucial to maintain product…

Solid Dosage form, Tablets