Tag: pharmaceutical development

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets

March 21, 2025 Admin

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Introduction: Enteric tablets are specially designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This targeted dissolution is critical for drugs that are sensitive to stomach acid…

Solid Dosage form, Tablets

Addressing Brittleness in High-Compression Tablets During Stability Studies

March 21, 2025 Admin

Addressing Brittleness in High-Compression Tablets During Stability Studies Addressing Brittleness in High-Compression Tablets During Stability Studies Introduction: In the pharmaceutical industry, the development and production of solid dosage forms, particularly tablets, is a critical aspect of delivering effective therapies to patients. High-compression tablets are increasingly popular due to their compact size and ease of production….

Solid Dosage form, Tablets

Ensuring Robustness in Content Uniformity Tests for Multi-Layer Tablets

March 20, 2025 Admin

Ensuring Robustness in Content Uniformity Tests for Multi-Layer Tablets Ensuring Robustness in Content Uniformity Tests for Multi-Layer Tablets Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms such as multi-layer tablets is of paramount importance. Multi-layer tablets offer the advantage of combining different drugs or release profiles in a single…

Solid Dosage form, Tablets

Addressing Over-Sensitivity to Humidity in Hygroscopic Tablets

March 19, 2025 Admin

Addressing Over-Sensitivity to Humidity in Hygroscopic Tablets Addressing Over-Sensitivity to Humidity in Hygroscopic Tablets Introduction: In the pharmaceutical industry, the stability of solid dosage forms like tablets is paramount to ensuring efficacy and safety. Hygroscopic tablets, which readily absorb moisture from their environment, present unique challenges in terms of formulation, manufacturing, and storage. Over-sensitivity to…

Solid Dosage form, Tablets

Ensuring Consistency in Content Uniformity Tests Across Batches

March 19, 2025 Admin

Ensuring Consistency in Content Uniformity Tests Across Batches Ensuring Consistency in Content Uniformity Tests Across Batches Introduction: In the pharmaceutical industry, the consistency of content uniformity tests across batches is pivotal to ensuring the safety and efficacy of solid dosage forms, particularly tablets. Content uniformity is a critical quality attribute that determines whether each tablet…

Solid Dosage form, Tablets

Managing Over-Compression in Tablets with High-Dose APIs

March 18, 2025 Admin

Managing Over-Compression in Tablets with High-Dose APIs Managing Over-Compression in Tablets with High-Dose APIs Introduction: The pharmaceutical industry is increasingly challenged with the development and manufacturing of tablets that contain high-dose Active Pharmaceutical Ingredients (APIs). While these tablets are crucial for ensuring therapeutic efficacy, they come with a unique set of challenges, particularly in terms…

Solid Dosage form, Tablets

Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets

March 18, 2025 Admin

Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets Avoiding Over-Sensitivity to Moisture in Hygroscopic Tablets Introduction: In the world of pharmaceuticals, the stability and efficacy of tablets are of utmost importance. Hygroscopic tablets, which have a tendency to absorb moisture from the environment, pose unique challenges in maintaining their integrity and functionality. Moisture sensitivity can lead…

Solid Dosage form, Tablets

Ensuring Consistency in Dissolution Testing for Multi-API Tablets

March 16, 2025 Admin

Ensuring Consistency in Dissolution Testing for Multi-API Tablets Ensuring Consistency in Dissolution Testing for Multi-API Tablets Introduction: Dissolution testing is a critical quality control measure in the pharmaceutical industry, particularly for tablets containing multiple active pharmaceutical ingredients (APIs). Ensuring consistency in dissolution testing is vital as it impacts the tablet’s efficacy, safety, and regulatory compliance….

Solid Dosage form, Tablets

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time

March 14, 2025 Admin

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Introduction: The development of sustained release tablets represents a significant advancement in pharmaceutical technology, aiming to provide consistent therapeutic effects over extended periods. These formulations are essential for enhancing patient compliance, minimizing dosing…

Solid Dosage form, Tablets

Resolving Failures in Disintegration Testing for Sustained Release Tablets

March 13, 2025 Admin

Resolving Failures in Disintegration Testing for Sustained Release Tablets Resolving Failures in Disintegration Testing for Sustained Release Tablets Introduction: In the pharmaceutical industry, ensuring the efficacy and safety of solid dosage forms such as tablets is paramount. Sustained release tablets, designed to release a drug at a predetermined rate, present unique challenges in quality control,…

Solid Dosage form, Tablets

High variability in stability data for oil-filled capsules.

March 12, 2025 Admin

High variability in stability data for oil-filled capsules. High variability in stability data for oil-filled capsules. Introduction: In the pharmaceutical industry, maintaining the stability of medicinal products is crucial to ensure their safety, efficacy, and quality over their shelf life. Among various dosage forms, oil-filled capsules—encompassing both hard and soft gelatin variants—present unique challenges in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Failures in Moisture Content Tests for Hygroscopic APIs

March 11, 2025 Admin

Managing Failures in Moisture Content Tests for Hygroscopic APIs Managing Failures in Moisture Content Tests for Hygroscopic APIs Introduction: In the pharmaceutical industry, Active Pharmaceutical Ingredients (APIs) form the backbone of drug manufacturing. Among these, hygroscopic APIs present unique challenges due to their inherent ability to absorb moisture from the environment. Accurate moisture content testing…

Solid Dosage form, Tablets