Tag: pharmaceutical development

Poor reproducibility in disintegration testing for coated capsules.

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Poor reproducibility in disintegration testing for coated capsules. Poor reproducibility in disintegration testing for coated capsules Introduction: In the pharmaceutical industry, disintegration testing is a critical quality control measure that ensures that oral dosage forms, such as capsules, break down within a specified time to release their active ingredients. This is particularly important for coated…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in API stability data for high-dose capsules.

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Poor reproducibility in API stability data for high-dose capsules. Poor reproducibility in API stability data for high-dose capsules Introduction: In the pharmaceutical industry, the stability of active pharmaceutical ingredients (APIs) is crucial for ensuring drug safety and efficacy. For high-dose capsules, achieving consistent and reproducible stability data is particularly challenging. Variability in stability data can…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Color Changes in Film-Coated Tablets During Stability Studies

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Addressing Color Changes in Film-Coated Tablets During Stability Studies Addressing Color Changes in Film-Coated Tablets During Stability Studies Introduction: In the pharmaceutical industry, maintaining the integrity and appearance of film-coated tablets throughout their shelf life is crucial. Stability studies play a significant role in ensuring that these products meet quality standards over time. One common…

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Solid Dosage form, Tablets

Problems with maintaining consistent dissolution profiles over the product’s shelf life.

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Problems with maintaining consistent dissolution profiles over the product’s shelf life. Problems with maintaining consistent dissolution profiles over the product’s shelf life. Introduction: The dissolution profile of a pharmaceutical product is a critical parameter that impacts its efficacy and safety. Consistency in dissolution profiles over the product’s shelf life ensures that the drug is released…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Impact of Oxidative Stress on Sugar-Coated Tablets

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Addressing Impact of Oxidative Stress on Sugar-Coated Tablets Addressing Impact of Oxidative Stress on Sugar-Coated Tablets Introduction: In the pharmaceutical industry, the stability of drug formulations is paramount to ensuring efficacy and safety. Among the various solid dosage forms, sugar-coated tablets offer unique benefits such as taste masking and protection of active ingredients. However, these…

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Solid Dosage form, Tablets

Problems with achieving consistent shell thickness for multi-particulate capsules.

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Problems with achieving consistent shell thickness for multi-particulate capsules. Problems with achieving consistent shell thickness for multi-particulate capsules. Introduction: In the pharmaceutical industry, the production of multi-particulate capsules has become increasingly significant due to their advantages in controlled drug release and patient compliance. However, achieving consistent shell thickness in these capsules is crucial for ensuring…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Non-Homogeneity in API Distribution in Multi-API Tablets

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Resolving Non-Homogeneity in API Distribution in Multi-API Tablets Resolving Non-Homogeneity in API Distribution in Multi-API Tablets Introduction: In the dynamic sphere of pharmaceutical manufacturing, ensuring the consistent distribution of Active Pharmaceutical Ingredients (APIs) within multi-API tablets is crucial. These tablets, designed to deliver multiple therapeutic effects, require precise formulation to ensure that each dose is…

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Solid Dosage form, Tablets

Difficulty in testing capsules with multi-phase drug release profiles.

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Difficulty in testing capsules with multi-phase drug release profiles. Difficulty in testing capsules with multi-phase drug release profiles. Introduction: In the ever-evolving landscape of pharmaceutical development, capsules with multi-phase drug release profiles have emerged as a sophisticated solution to optimize therapeutic outcomes. These formulations are designed to release active ingredients at different intervals, ensuring prolonged…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate protocols for evaluating shell-to-fill interaction effects.

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Inadequate protocols for evaluating shell-to-fill interaction effects. Inadequate Protocols for Evaluating Shell-to-Fill Interaction Effects in Capsules Introduction: In the pharmaceutical industry, solid oral dosage forms such as capsules are a staple due to their ease of administration and versatility. Capsules, which can be either hard or soft gelatin, serve as a vehicle to deliver active…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule drying processes for thermosensitive APIs.

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Difficulty in validating capsule drying processes for thermosensitive APIs. Difficulty in validating capsule drying processes for thermosensitive APIs Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and efficacy of Active Pharmaceutical Ingredients (APIs) is paramount. Thermosensitive APIs, which are prone to degradation at elevated temperatures, pose unique challenges. As capsules, especially hard and…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High variability in capsule weight due to uneven powder blending.

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High variability in capsule weight due to uneven powder blending. High Variability in Capsule Weight Due to Uneven Powder Blending Introduction: In the pharmaceutical industry, ensuring consistent capsule weight is critical for maintaining drug efficacy and patient safety. High variability in capsule weight can lead to suboptimal therapeutic outcomes and regulatory non-compliance. Uneven powder blending…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Powder Segregation in High-Speed Blending Equipment

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Managing Powder Segregation in High-Speed Blending Equipment Managing Powder Segregation in High-Speed Blending Equipment Introduction: In the pharmaceutical industry, achieving uniformity in solid dosage forms is crucial for ensuring efficacy and patient safety. High-speed blending equipment is commonly used in the production of tablets to mix powdered ingredients. However, one of the significant challenges in…

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Solid Dosage form, Tablets