Tag: pharmaceutical compliance

Preventing Over-Drying of Granules During Fluid Bed Processing

April 1, 2025 Admin

Preventing Over-Drying of Granules During Fluid Bed Processing Preventing Over-Drying of Granules During Fluid Bed Processing Introduction: Fluid bed processing is a cornerstone of pharmaceutical manufacturing, especially in the production of solid dosage forms such as tablets. The process involves suspending particles in a flowing gas stream, typically air, which facilitates the drying of granules…

Solid Dosage form, Tablets

Identifying Problems in Potency Testing for Extended Release Tablets

March 31, 2025 Admin

Identifying Problems in Potency Testing for Extended Release Tablets Identifying Problems in Potency Testing for Extended Release Tablets Introduction: Extended release tablets are a cornerstone of modern pharmaceutical therapy, providing patients with the convenience of reduced dosing frequency while maintaining therapeutic efficacy over an extended period. Potency testing of these formulations is critical to ensure…

Solid Dosage form, Tablets

Troubleshooting Variability in Thickness Testing for Film-Coated Tablets

March 31, 2025 Admin

Troubleshooting Variability in Thickness Testing for Film-Coated Tablets Troubleshooting Variability in Thickness Testing for Film-Coated Tablets Introduction: In the pharmaceutical industry, the production of film-coated tablets is a critical process that requires meticulous quality control. Thickness testing of these tablets is vital as it ensures uniformity, stability, and efficacy of the dosage form. Variability in…

Solid Dosage form, Tablets

Ensuring Batch Record Accuracy During Tablet Manufacturing

March 27, 2025 Admin

Ensuring Batch Record Accuracy During Tablet Manufacturing Ensuring Batch Record Accuracy During Tablet Manufacturing Introduction: In the pharmaceutical industry, the manufacturing of tablets is a critical process that requires precision, consistency, and adherence to stringent regulatory standards. Ensuring batch record accuracy is pivotal not only for compliance with regulatory requirements but also for ensuring product…

Solid Dosage form, Tablets

Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production

March 27, 2025 Admin

Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production Introduction: Hygroscopic tablets are an essential component of the pharmaceutical industry, offering a convenient and effective means of delivering medication to patients. However, their production poses significant challenges due to their sensitivity to humidity. Excess moisture can…

Solid Dosage form, Tablets

Ensuring Consistency in API Release Profiles for Controlled Release Tablets

March 26, 2025 Admin

Ensuring Consistency in API Release Profiles for Controlled Release Tablets Ensuring Consistency in API Release Profiles for Controlled Release Tablets Introduction: In the world of pharmaceuticals, controlled release tablets play a pivotal role in ensuring the therapeutic efficacy of drugs. These formulations are designed to release active pharmaceutical ingredients (APIs) at a predetermined rate, maintaining…

Solid Dosage form, Tablets

Managing Residual Solvents in Solvent-Based Coating Applications

March 26, 2025 Admin

Managing Residual Solvents in Solvent-Based Coating Applications Managing Residual Solvents in Solvent-Based Coating Applications Introduction: The use of solvent-based coatings in the pharmaceutical industry plays a crucial role in enhancing the stability, appearance, and functionality of solid dosage forms such as tablets. However, managing residual solvents in these applications is paramount to ensure the safety,…

Solid Dosage form, Tablets

Poor validation of water purification systems for high-demand operations.

March 25, 2025 Admin

Poor validation of water purification systems for high-demand operations. Poor validation of water purification systems for high-demand operations. Introduction: Water purification systems are integral to pharmaceutical manufacturing, especially in the production of solid oral dosage forms like capsules. The quality of water used directly impacts the safety and efficacy of oral medications. However, poor validation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Over-Lubrication in Powder Blends During Compression

March 25, 2025 Admin

Addressing Over-Lubrication in Powder Blends During Compression Addressing Over-Lubrication in Powder Blends During Compression Introduction: In the pharmaceutical industry, the production of high-quality tablets is pivotal. The tablet compression process is a critical phase where powder blends are transformed into solid dosage forms. However, one of the common challenges faced during this process is over-lubrication,…

Solid Dosage form, Tablets

Poor validation of capsule transparency for certain formulations.

March 25, 2025 Admin

Poor validation of capsule transparency for certain formulations. Poor validation of capsule transparency for certain formulations. Introduction: In the pharmaceutical industry, the transparency of capsules, especially gelatin-based ones, plays a critical role in both consumer perception and regulatory compliance. The visual clarity of capsules can affect patient trust, as transparency often signifies purity and lack…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Challenges in Process Validation for Immediate Release Tablets

March 24, 2025 Admin

Addressing Challenges in Process Validation for Immediate Release Tablets Addressing Challenges in Process Validation for Immediate Release Tablets Introduction: Immediate release tablets are a cornerstone in the pharmaceutical industry, known for their rapid disintegration and absorption properties, providing swift therapeutic effects. As the demand for these tablets continues to grow, ensuring their efficacy and safety…

Solid Dosage form, Tablets

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets

March 24, 2025 Admin

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to resist the acidic environment of the stomach and release active pharmaceutical ingredients (APIs) in the more neutral pH of the intestines. This controlled release profile is…

Solid Dosage form, Tablets