Tag: pharmaceutical best practices

Troubleshooting Heat Sensitivity Problems During Validation of Compression Stages

April 4, 2025 Admin

Troubleshooting Heat Sensitivity Problems During Validation of Compression Stages Troubleshooting Heat Sensitivity Problems During Validation of Compression Stages Introduction: In the realm of pharmaceutical manufacturing, tablet compression is a critical process that ensures the production of solid dosage forms that are both effective and safe. During this process, heat sensitivity can present significant challenges that…

Solid Dosage form, Tablets

Problems with ensuring consistent capsule wall thickness.

April 4, 2025 Admin

Problems with ensuring consistent capsule wall thickness. Problems with Ensuring Consistent Capsule Wall Thickness Introduction: In the pharmaceutical industry, capsules are a prevalent dosage form, prized for their ability to deliver precise doses of medication efficiently. However, one of the key challenges in capsule manufacturing is ensuring consistent wall thickness, which is crucial for maintaining…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Moisture Absorption Issues in Hygroscopic Tablets During Storage

April 4, 2025 Admin

Resolving Moisture Absorption Issues in Hygroscopic Tablets During Storage Resolving Moisture Absorption Issues in Hygroscopic Tablets During Storage Introduction: In the pharmaceutical industry, hygroscopic tablets present unique challenges due to their propensity to absorb moisture from the environment. This characteristic can adversely affect the stability, efficacy, and shelf life of the medication. Understanding and mitigating…

Solid Dosage form, Tablets

Problems with maintaining consistent capsule hardness.

April 4, 2025 Admin

Problems with maintaining consistent capsule hardness. Problems with Maintaining Consistent Capsule Hardness Introduction: Capsules, whether hard or soft gelatin, are among the most prevalent forms of solid oral dosage forms in the pharmaceutical industry. Ensuring consistent capsule hardness is crucial as it affects the product’s stability, dissolution rate, and bioavailability. Variability in capsule hardness can…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in gelatin cross-linking data under various storage conditions.

April 4, 2025 Admin

Poor reproducibility in gelatin cross-linking data under various storage conditions. Poor Reproducibility in Gelatin Cross-Linking Data Under Various Storage Conditions Introduction: In the pharmaceutical industry, the stability and integrity of solid oral dosage forms, particularly capsules, are paramount. Gelatin, a common excipient used in hard and soft capsules, undergoes a process known as cross-linking, which…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of compressed air systems for particulate contamination.

April 3, 2025 Admin

Poor validation of compressed air systems for particulate contamination. Poor validation of compressed air systems for particulate contamination. Introduction: In the pharmaceutical industry, maintaining the integrity and purity of solid oral dosage forms such as hard and soft gelatin capsules is paramount. Compressed air systems play a critical role in various stages of pharmaceutical manufacturing,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor alignment of capsules within blister packaging.

April 3, 2025 Admin

Poor alignment of capsules within blister packaging. Poor alignment of capsules within blister packaging. Introduction: Blister packaging is a widely used method in the pharmaceutical industry for the protection and distribution of solid oral dosage forms like capsules. This packaging format not only safeguards the product from environmental factors, such as moisture and light, but…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Seal Delamination Issues in Strip Packs for Hygroscopic Tablets

April 2, 2025 Admin

Addressing Seal Delamination Issues in Strip Packs for Hygroscopic Tablets Addressing Seal Delamination Issues in Strip Packs for Hygroscopic Tablets Introduction: In the pharmaceutical industry, the packaging of hygroscopic tablets presents unique challenges due to their sensitivity to moisture. Hygroscopic tablets are designed to absorb moisture from the environment, which can compromise the tablet’s integrity…

Solid Dosage form, Tablets

Problems with ensuring consistent gelatin plasticizer levels during validation.

April 2, 2025 Admin

Problems with ensuring consistent gelatin plasticizer levels during validation. Problems with Ensuring Consistent Gelatin Plasticizer Levels During Validation Introduction: The pharmaceutical industry faces numerous challenges when it comes to the formulation and validation of solid oral dosage forms, particularly capsules. Among these challenges, ensuring consistent gelatin plasticizer levels is critical in maintaining the quality and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule drying processes for dual-layer capsules.

April 2, 2025 Admin

Difficulty in validating capsule drying processes for dual-layer capsules. Difficulty in validating capsule drying processes for dual-layer capsules Introduction: The pharmaceutical industry is constantly evolving, with innovations aimed at improving drug delivery systems and enhancing patient compliance. One such innovation is the development of dual-layer capsules. These capsules offer the advantage of delivering multiple drugs…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule drying processes for thermosensitive APIs.

April 1, 2025 Admin

Difficulty in validating capsule drying processes for thermosensitive APIs. Difficulty in validating capsule drying processes for thermosensitive APIs Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and efficacy of Active Pharmaceutical Ingredients (APIs) is paramount. Thermosensitive APIs, which are prone to degradation at elevated temperatures, pose unique challenges. As capsules, especially hard and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Robustness in Quality Management Systems for Multi-Layer Tablets

March 31, 2025 Admin

Ensuring Robustness in Quality Management Systems for Multi-Layer Tablets Ensuring Robustness in Quality Management Systems for Multi-Layer Tablets Introduction: In the pharmaceutical industry, multi-layer tablets represent a significant advancement in drug delivery systems. They offer distinct advantages such as controlled release profiles, improved patient compliance, and the ability to combine incompatible drugs into a single…

Solid Dosage form, Tablets