Tag: pharmaceutical best practices

Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity

May 6, 2025 Admin

Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity Troubleshooting API Loss in Extended Release Tablets Stored at High Humidity Introduction: Extended release tablets are a cornerstone of modern pharmaceutical formulations, offering controlled release of active pharmaceutical ingredients (APIs) over time to improve patient compliance and therapeutic efficacy. However, when these tablets are…

Solid Dosage form, Tablets

Ensuring Robustness of Coating Adhesion in Multi-API Tablets Over Time

May 4, 2025 Admin

Ensuring Robustness of Coating Adhesion in Multi-API Tablets Over Time Ensuring Robustness of Coating Adhesion in Multi-API Tablets Over Time Introduction: In the dynamic landscape of pharmaceutical manufacturing, ensuring the robustness of coating adhesion in multi-API (Active Pharmaceutical Ingredient) tablets is crucial. The coating plays a pivotal role in protecting the drug, controlling its release,…

Solid Dosage form, Tablets

Validating Cleaning Effectiveness for Wet Granulation Equipment

May 4, 2025 Admin

Validating Cleaning Effectiveness for Wet Granulation Equipment Validating Cleaning Effectiveness for Wet Granulation Equipment Introduction: In the pharmaceutical industry, maintaining the cleanliness and functionality of equipment is paramount to ensuring product quality and patient safety. Wet granulation, a critical step in tablet production, involves the agglomeration of powder particles using a liquid binder. This process,…

Solid Dosage form, Tablets

Challenges in achieving uniform capsule transparency during validation.

May 3, 2025 Admin

Challenges in achieving uniform capsule transparency during validation. Challenges in achieving uniform capsule transparency during validation. Introduction: In the pharmaceutical industry, the demand for consistent and high-quality solid oral dosage forms has never been greater. Among these, capsules, particularly hard and soft gelatin capsules, stand out due to their versatility and consumer preference for ease…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Poor Coating Adhesion in Extended Release Tablets Over Time

May 3, 2025 Admin

Troubleshooting Poor Coating Adhesion in Extended Release Tablets Over Time Troubleshooting Poor Coating Adhesion in Extended Release Tablets Over Time Introduction: Extended release tablets are a crucial aspect of modern pharmaceutical delivery systems, offering consistent therapeutic effects over extended periods. However, the integrity of their coating is paramount to ensure proper drug release and efficacy….

Solid Dosage form, Tablets

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies

May 3, 2025 Admin

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Introduction: In the realm of pharmaceuticals, ensuring consistency in the disintegration time of tablets during long-term stability studies is pivotal for guaranteeing a drug’s efficacy, safety, and patient compliance. Disintegration time is a critical quality attribute that…

Solid Dosage form, Tablets

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures

May 1, 2025 Admin

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Introduction: In the pharmaceutical industry, the stability of Active Pharmaceutical Ingredients (APIs) is crucial for ensuring the efficacy and safety of medications. Film-coated tablets are a popular dosage form, offering benefits such as ease of…

Solid Dosage form, Tablets

Ensuring Robustness in Weight Variation Control During Compression Validation

May 1, 2025 Admin

Ensuring Robustness in Weight Variation Control During Compression Validation Ensuring Robustness in Weight Variation Control During Compression Validation Introduction: In the pharmaceutical industry, ensuring the uniformity and consistency of tablet production is crucial. Weight variation in tablets can lead to significant quality issues, impacting both efficacy and safety. This makes weight variation control a critical…

Solid Dosage form, Tablets

Challenges in validating nitrogen purity for capsule storage conditions.

April 29, 2025 Admin

Challenges in validating nitrogen purity for capsule storage conditions. Challenges in validating nitrogen purity for capsule storage conditions. Introduction: In the pharmaceutical industry, maintaining the integrity and stability of solid oral dosage forms such as capsules is paramount. The use of nitrogen as an inert gas in storage environments plays a crucial role in preserving…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets

April 28, 2025 Admin

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Introduction: Coated tablets are a widely used solid dosage form in the pharmaceutical industry, offering benefits such as improved taste masking, controlled drug release, and enhanced stability. However, achieving consistent dissolution profiles is critical as it directly impacts the…

Solid Dosage form, Tablets

Addressing Deviations in Stability Studies for Bilayer Tablets

April 27, 2025 Admin

Addressing Deviations in Stability Studies for Bilayer Tablets Addressing Deviations in Stability Studies for Bilayer Tablets Introduction: Bilayer tablets have emerged as a versatile drug delivery system, offering the advantage of combining two different drugs or formulations with varied release profiles in a single dosage form. This innovation not only improves patient compliance but also…

Solid Dosage form, Tablets

Poor reproducibility in cleaning validation results for multi-product facilities.

April 26, 2025 Admin

Poor reproducibility in cleaning validation results for multi-product facilities. Poor reproducibility in cleaning validation results for multi-product facilities. Introduction: In the pharmaceutical industry, ensuring that equipment is properly cleaned between different product batches is critical to maintaining product quality and patient safety. Multi-product facilities, which manufacture a variety of pharmaceutical products, face unique challenges in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms