Tag: pharmaceutical best practices

Inadequate systems for monitoring capsule integrity during validation.

March 9, 2025 Admin

Inadequate systems for monitoring capsule integrity during validation. Inadequate Systems for Monitoring Capsule Integrity During Validation Introduction: In the pharmaceutical industry, the integrity of capsules, whether hard or soft gelatin, is crucial for ensuring the efficacy and safety of the medication contained within. Monitoring capsule integrity during validation is an essential part of the manufacturing…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Reducing Rejection Rates in Automated Coating Processes

March 9, 2025 Admin

Reducing Rejection Rates in Automated Coating Processes Reducing Rejection Rates in Automated Coating Processes Introduction: The pharmaceutical industry is continuously evolving, with automation playing a pivotal role in enhancing efficiency and consistency in manufacturing processes. One critical aspect of tablet production is the coating process, which not only improves the aesthetic appeal of tablets but…

Solid Dosage form, Tablets

Ensuring Robustness in Weight Uniformity Tests Across Tablet Batches

March 9, 2025 Admin

Ensuring Robustness in Weight Uniformity Tests Across Tablet Batches Ensuring Robustness in Weight Uniformity Tests Across Tablet Batches Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistency and quality of solid dosage forms, such as tablets, is paramount. One critical aspect of quality control is the weight uniformity test, which ensures that each tablet…

Solid Dosage form, Tablets

Addressing Non-Adherence of Coating Layers in Film-Coated Tablets

March 9, 2025 Admin

Addressing Non-Adherence of Coating Layers in Film-Coated Tablets Addressing Non-Adherence of Coating Layers in Film-Coated Tablets Introduction: Film-coated tablets are a cornerstone of modern pharmaceutical delivery systems, providing benefits such as improved stability, controlled drug release, and enhanced patient compliance. However, challenges such as the non-adherence of coating layers can compromise the efficacy and quality…

Solid Dosage form, Tablets

Managing Fines Generation in Fluid Bed Processing

March 9, 2025 Admin

Managing Fines Generation in Fluid Bed Processing Managing Fines Generation in Fluid Bed Processing Introduction: Fluid bed processing is a critical operation in pharmaceutical manufacturing, primarily utilized for drying, granulating, and coating purposes. Its efficiency and effectiveness in producing uniform and quality granules make it a preferred choice in tablet production. However, a persistent challenge…

Solid Dosage form, Tablets

High variability in results of content uniformity testing for low-dose drugs.

March 8, 2025 Admin

High variability in results of content uniformity testing for low-dose drugs. High Variability in Results of Content Uniformity Testing for Low-Dose Drugs Introduction: The pharmaceutical industry is tasked with the critical role of ensuring that every dose of medication administered to patients is safe, effective, and of high quality. One of the major quality control…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Validating Adequacy of Binder Concentration in Wet Granulation Processes

March 8, 2025 Admin

Validating Adequacy of Binder Concentration in Wet Granulation Processes Validating Adequacy of Binder Concentration in Wet Granulation Processes Introduction: In the realm of pharmaceutical manufacturing, the wet granulation process is a cornerstone for producing high-quality tablets. Ensuring the adequacy of binder concentration is critical in this process, as it directly influences the tablet’s integrity, dissolution…

Solid Dosage form, Tablets

Challenges in validating sealing equipment for tamper-evident capsules.

March 8, 2025 Admin

Challenges in validating sealing equipment for tamper-evident capsules. Challenges in validating sealing equipment for tamper-evident capsules. Introduction: In the ever-evolving pharmaceutical industry, ensuring the safety and integrity of solid oral dosage forms, like capsules, is paramount. Tamper-evident capsules offer an additional layer of security, safeguarding consumers against potential product tampering. However, the process of validating…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes

March 8, 2025 Admin

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Introduction: The pharmaceutical industry relies heavily on the integrity and efficacy of solid dosage forms like tablets. Among these, sugar-coated tablets have been traditionally used for their aesthetic appeal and ability to mask unpleasant tastes. However, the…

Solid Dosage form, Tablets

Difficulty in validating capsule sealing for capsules with multi-layer fills.

March 8, 2025 Admin

Difficulty in validating capsule sealing for capsules with multi-layer fills. Difficulty in validating capsule sealing for capsules with multi-layer fills Introduction: Capsules have long been a preferred dosage form in the pharmaceutical industry due to their versatility and convenience. The advent of multi-layer fills in capsules has paved the way for innovative drug delivery systems….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Optimizing Layer Adhesion in Bilayer Tablet Compression

March 7, 2025 Admin

Optimizing Layer Adhesion in Bilayer Tablet Compression Optimizing Layer Adhesion in Bilayer Tablet Compression Introduction: Bilayer tablets are an innovative solution in the pharmaceutical industry, allowing for the combination of two active ingredients with distinct release profiles or chemical characteristics. This format is crucial in cases where combination therapy is necessary, providing patient convenience and…

Solid Dosage form, Tablets

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes

March 7, 2025 Admin

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Introduction: In the pharmaceutical industry, coated tablets are among the most common solid dosage forms due to their advantages in masking unpleasant tastes, improving stability, and controlling drug release. However, the process of coating tablets can be highly sensitive…

Solid Dosage form, Tablets