Tag: pharmaceutical best practices

Managing Solvent Levels in Film-Coating Processes for Consistency

March 26, 2025 Admin

Managing Solvent Levels in Film-Coating Processes for Consistency Managing Solvent Levels in Film-Coating Processes for Consistency Introduction: In the pharmaceutical industry, the film-coating process of tablets is a crucial step that ensures not only the aesthetic appeal but also the stability and controlled release of the active pharmaceutical ingredients (APIs). Managing solvent levels during this…

Solid Dosage form, Tablets

Challenges in validating cleaning processes for aqueous-based capsule formulations.

March 26, 2025 Admin

Challenges in validating cleaning processes for aqueous-based capsule formulations. Challenges in validating cleaning processes for aqueous-based capsule formulations Introduction: In the pharmaceutical industry, ensuring the cleanliness of manufacturing equipment is paramount, especially when dealing with aqueous-based capsule formulations. These formulations, found in both hard and soft gelatin capsules, pose unique challenges due to their propensity…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Real-Time Monitoring of Granulation Moisture Levels During Wet Granulation

March 23, 2025 Admin

Real-Time Monitoring of Granulation Moisture Levels During Wet Granulation Real-Time Monitoring of Granulation Moisture Levels During Wet Granulation Introduction: In the pharmaceutical industry, the manufacturing of solid dosage forms such as tablets often involves the process of wet granulation. This critical process ensures the homogeneity and compressibility of the drug mixture. One of the most…

Solid Dosage form, Tablets

Managing Non-Compliance in Packaging Validation for Hygroscopic Tablets

March 23, 2025 Admin

Managing Non-Compliance in Packaging Validation for Hygroscopic Tablets Managing Non-Compliance in Packaging Validation for Hygroscopic Tablets Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of drug products is paramount. This is particularly crucial for hygroscopic tablets that are prone to absorbing moisture, which can compromise their integrity and therapeutic effectiveness. Managing non-compliance in…

Solid Dosage form, Tablets

Controlling Over-Spray in Sugar-Coated Tablet Processes

March 23, 2025 Admin

Controlling Over-Spray in Sugar-Coated Tablet Processes Controlling Over-Spray in Sugar-Coated Tablet Processes Introduction: Sugar-coating is a traditional method in the pharmaceutical industry, primarily used to enhance the aesthetic appeal and taste of tablets. However, controlling over-spray during the sugar-coating process is critical to ensuring product quality and compliance with regulatory standards. Over-spray can lead to…

Solid Dosage form, Tablets

Ensuring Tearability of Strip Packaging for Pediatric Use Tablets

March 22, 2025 Admin

Ensuring Tearability of Strip Packaging for Pediatric Use Tablets Ensuring Tearability of Strip Packaging for Pediatric Use Tablets Introduction: The pharmaceutical industry constantly strives to make medications more accessible and safer, particularly for vulnerable populations like children. Strip packaging, a widely used method for solid dosage forms like tablets, offers several benefits, including protection from…

Solid Dosage form, Tablets

Poor reproducibility in weight variation data for capsules over storage periods.

March 22, 2025 Admin

Poor reproducibility in weight variation data for capsules over storage periods. Poor reproducibility in weight variation data for capsules over storage periods. Introduction: In the pharmaceutical industry, ensuring the consistency and quality of solid oral dosage forms such as capsules is critical. Capsules, whether hard or soft gelatin, are widely used due to their ease…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets

March 22, 2025 Admin

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Introduction: In the pharmaceutical industry, film-coated tablets represent a significant portion of solid dosage forms due to their enhanced stability, ease of swallowing, and aesthetic attributes. The coating process is critical, as it affects the tablet’s performance and patient…

Solid Dosage form, Tablets

Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets

March 22, 2025 Admin

Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets Troubleshooting Non-Adherence of Coating Layers in Extended Release Tablets Introduction: In the pharmaceutical industry, extended release tablets play a crucial role in delivering medication over a prolonged period, enhancing patient compliance and therapeutic efficacy. However, one of the persistent challenges in their production is the non-adherence…

Solid Dosage form, Tablets

Preventing Coating Layer Delamination in Extended Release Tablets

March 22, 2025 Admin

Preventing Coating Layer Delamination in Extended Release Tablets Preventing Coating Layer Delamination in Extended Release Tablets Introduction: In the pharmaceutical industry, the development of extended release tablets presents a significant advancement in drug delivery systems. These tablets are engineered to release medication at a predetermined rate, thereby maintaining a consistent drug concentration for an extended…

Solid Dosage form, Tablets

Addressing Over-Lubrication in Powder Mixtures for Blending

March 21, 2025 Admin

Addressing Over-Lubrication in Powder Mixtures for Blending Addressing Over-Lubrication in Powder Mixtures for Blending Introduction: In the pharmaceutical industry, the formulation of solid dosage forms like tablets is a finely tuned process that requires precision and careful consideration of multiple variables. Among these, the use of lubricants in powder mixtures for blending is crucial to…

Solid Dosage form, Tablets

Problems with ensuring consistent nitrogen distribution for capsule production.

March 21, 2025 Admin

Problems with ensuring consistent nitrogen distribution for capsule production. Problems with ensuring consistent nitrogen distribution for capsule production. Introduction: In the pharmaceutical industry, the production of solid oral dosage forms such as capsules is a complex process that requires meticulous attention to detail. Among the various factors that influence capsule quality, the consistent distribution of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms