Tag: pharmaceutical best practices

Addressing Non-Compliance in Process Validation for Hygroscopic Tablets

June 4, 2025 Admin

Addressing Non-Compliance in Process Validation for Hygroscopic Tablets Addressing Non-Compliance in Process Validation for Hygroscopic Tablets Introduction: In the pharmaceutical industry, the process validation of hygroscopic tablets presents unique challenges. Hygroscopic tablets are those that have a tendency to absorb moisture from their surroundings, which can lead to significant issues in their stability, efficacy, and…

Solid Dosage form, Tablets

Managing Calibration Failures in Spray Gun Settings for Sustained Release Tablets

June 4, 2025 Admin

Managing Calibration Failures in Spray Gun Settings for Sustained Release Tablets Managing Calibration Failures in Spray Gun Settings for Sustained Release Tablets Introduction: In the pharmaceutical industry, ensuring the precise release profile of sustained release tablets is crucial for therapeutic efficacy and patient safety. One of the key processes in manufacturing these tablets is the…

Solid Dosage form, Tablets

Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets

June 2, 2025 Admin

Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets Troubleshooting Non-Adherence of Coating Layers in Multi-Layer Tablets Introduction: In the pharmaceutical industry, multi-layer tablets are gaining prominence due to their ability to deliver multiple drugs or achieve controlled release profiles. However, these complex formulations often face challenges, particularly with the adherence of coating layers. Ensuring that…

Solid Dosage form, Tablets

Investigating Impact of Humidity on Coating Integrity in Film-Coated Tablets

May 31, 2025 Admin

Investigating Impact of Humidity on Coating Integrity in Film-Coated Tablets Investigating Impact of Humidity on Coating Integrity in Film-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the integrity of film-coated tablets is a critical aspect of product quality and efficacy. Film coatings on tablets serve multiple purposes, including protection from environmental factors, masking unpleasant tastes,…

Solid Dosage form, Tablets

Ensuring Accuracy in Compression Force Sensors During Tablet Press Validation

May 29, 2025 Admin

Ensuring Accuracy in Compression Force Sensors During Tablet Press Validation Ensuring Accuracy in Compression Force Sensors During Tablet Press Validation Introduction: In the pharmaceutical industry, precision in tablet manufacturing is paramount. Ensuring the accuracy of compression force sensors during tablet press validation is critical for maintaining the quality and uniformity of tablets. These sensors play…

Solid Dosage form, Tablets

Troubleshooting Failures in Rinse Sampling for Fluid Bed Dryers During Validation

May 28, 2025 Admin

Troubleshooting Failures in Rinse Sampling for Fluid Bed Dryers During Validation Troubleshooting Failures in Rinse Sampling for Fluid Bed Dryers During Validation Introduction: Rinse sampling is a critical step in the validation of fluid bed dryers within pharmaceutical manufacturing. Ensuring that no residues of active pharmaceutical ingredients (APIs) or cleaning agents remain is essential for…

Solid Dosage form, Tablets

Ensuring Robustness in Layer Adhesion for Bilayer Tablet Equipment Validation

May 27, 2025 Admin

Ensuring Robustness in Layer Adhesion for Bilayer Tablet Equipment Validation Ensuring Robustness in Layer Adhesion for Bilayer Tablet Equipment Validation Introduction: In the realm of pharmaceutical manufacturing, bilayer tablets have emerged as a significant advancement, offering multiple benefits such as the ability to combine incompatible substances, controlled release profiles, and patient convenience. However, the manufacturing…

Solid Dosage form, Tablets

Root Cause Analysis for Failures in Dissolution Testing for Enteric Tablets

May 19, 2025 Admin

Root Cause Analysis for Failures in Dissolution Testing for Enteric Tablets Root Cause Analysis for Failures in Dissolution Testing for Enteric Tablets Introduction: The pharmaceutical industry is committed to ensuring that medications are safe, effective, and of the highest quality. One critical aspect of this commitment is dissolution testing, particularly for enteric-coated tablets. These tablets…

Solid Dosage form, Tablets

Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing

May 19, 2025 Admin

Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing Resolving Layer Delamination in Multi-Layer Tablets Under Stress Testing Introduction: In the pharmaceutical industry, multi-layer tablets have become a sophisticated option for delivering multiple active pharmaceutical ingredients (APIs) with distinct release profiles. These tablets offer numerous advantages, including improved patient compliance and efficient dosing schedules. However,…

Solid Dosage form, Tablets

Validating Cleaning Procedures for Fluid Bed Dryers in Multi-Product Facilities

May 18, 2025 Admin

Validating Cleaning Procedures for Fluid Bed Dryers in Multi-Product Facilities Validating Cleaning Procedures for Fluid Bed Dryers in Multi-Product Facilities Introduction: In the pharmaceutical industry, fluid bed dryers are crucial for the production of solid dosage forms such as tablets. These sophisticated pieces of equipment facilitate the drying of granulated materials before tablet compression. In…

Solid Dosage form, Tablets

Addressing Non-Compliance in QA Tests for Multi-Layer Tablets

May 16, 2025 Admin

Addressing Non-Compliance in QA Tests for Multi-Layer Tablets Addressing Non-Compliance in QA Tests for Multi-Layer Tablets Introduction: In the pharmaceutical industry, multi-layer tablets have emerged as a preferred solid dosage form due to their ability to deliver multiple active pharmaceutical ingredients (APIs) in a single dose and to provide controlled release of medications. However, ensuring…

Solid Dosage form, Tablets

Validating Rinse Volume Requirements in Cleaning Validation Protocols

May 15, 2025 Admin

Validating Rinse Volume Requirements in Cleaning Validation Protocols Validating Rinse Volume Requirements in Cleaning Validation Protocols Introduction: In the pharmaceutical industry, ensuring that manufacturing equipment is free from contaminants is paramount to product safety and efficacy. Cleaning validation is a critical component of Good Manufacturing Practice (GMP) to confirm that cleaning processes are effective and…

Solid Dosage form, Tablets