Tag: Orally Disintegrating Tablets

Troubleshooting Granule Compression for Low-Dose Tablets Resolving Granule Compression Challenges in Low-Dose Tablets Why is Granule Compression Challenging for Low-Dose Tablets? Low-dose tablets, where the active pharmaceutical ingredient (API) is present in minute quantities, pose unique challenges during granule compression. Maintaining uniformity, achieving proper compaction, and preventing segregation of APIs and excipients are critical to…

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How to Formulate Coated Tablets for Controlled Release Formulating Coated Tablets for Effective Controlled Drug Release What Are Controlled-Release Coated Tablets? Controlled-release coated tablets are designed to deliver the active pharmaceutical ingredient (API) at a predetermined rate, duration, and location within the gastrointestinal tract. The coating plays a vital role in regulating drug release, providing…

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Developing Immediate-Release Tablets for Poorly Soluble Drugs Strategies for Formulating Immediate-Release Tablets with Poorly Soluble Drugs Why is Solubility a Challenge in Immediate-Release Tablets? Poorly soluble drugs present significant challenges in pharmaceutical formulation due to their limited ability to dissolve in the gastrointestinal tract. For immediate-release tablets, rapid dissolution and absorption are critical to achieve…

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How to Improve Flow Properties of Powder for Tablet Manufacturing Steps to Enhance Powder Flowability in Tablet Production Why is Powder Flow Important in Tablet Manufacturing? Powder flowability is a critical factor in tablet manufacturing as it ensures uniform die filling, consistent tablet weight, and efficient compression. Poor flow properties can lead to issues such…

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Preventing Tablet Layer Separation in Multilayer Tablets How to Avoid Tablet Layer Separation in Multilayer Tablets What is Tablet Layer Separation? Tablet layer separation, also known as delamination, occurs when the individual layers of a multilayer tablet fail to adhere to each other. This structural defect can lead to compromised drug efficacy, inconsistent release profiles,…

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How to Select Excipients for Slow-Release Tablets Key Considerations for Choosing Excipients in Slow-Release Tablet Formulations Why Are Excipients Critical in Slow-Release Tablets? Excipients are inactive ingredients in pharmaceutical formulations that play essential roles in tablet manufacturing, stability, and drug release. In slow-release tablets, the choice of excipients directly impacts the controlled-release profile, stability, and…

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Managing Lubricant Overuse in Tablet Formulations Effective Strategies to Control Lubricant Overuse in Tablet Manufacturing Why is Lubricant Overuse a Problem in Tablet Formulations? Lubricants are essential excipients used in tablet formulations to reduce friction between the tablet and the die wall during compression and ejection. However, excessive use of lubricants, such as magnesium stearate,…

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Direct Compression: Advantages and Disadvantages in Tablet Manufacturing Understanding Direct Compression in Tablet Production: Pros and Cons What is Direct Compression? Direct compression is a widely used technique in tablet manufacturing, where powdered materials are compressed directly into tablets without the need for granulation. This method is particularly popular for formulations like Immediate-Release Tablets, Orally…

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Understanding Tablet Compression and Its Challenges A Step-by-Step Tutorial on Tablet Compression and Overcoming Common Challenges What is Tablet Compression? Tablet compression is a critical step in pharmaceutical manufacturing where powder mixtures are compacted into solid doses using a tablet press. This process ensures that tablets like Immediate-Release Tablets, Orally Disintegrating Tablets (ODTs), and Film-Coated…

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Advances in Dry Granulation for Pharmaceutical Tablets Recent Innovations in Dry Granulation Techniques for Tablet Manufacturing The Evolution of Dry Granulation in Pharma Dry Granulation has been a cornerstone of pharmaceutical tablet production for decades. As a moisture- and heat-free process, it provides a reliable method for creating tablets like Immediate-Release Tablets and Compression-Coated Tablets….

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Capping in Tablets: Prevention and Troubleshooting Effective Tips to Prevent Capping in Tablets What is Capping in Tablets? In pharmaceutical manufacturing, capping occurs when the top or bottom layer of a tablet separates partially or completely from the main body during tablet compression. This defect compromises the tablet’s integrity, appearance, and functionality, especially for specialized…

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Understanding the Role of Lubricants in Tablet Formulation The Importance of Lubricants in Tablet Manufacturing Why Lubricants Are Crucial in Tablet Formulation In the pharmaceutical industry, lubricants play a critical role in ensuring smooth tablet manufacturing. They minimize friction during the compression and ejection processes, preventing damage to both the Immediate-Release Tablets and the machinery…

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