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Role of Lubricants in Capsule Filling Lubricants play a vital role in capsule filling processes to facilitate smooth and efficient operations. They are added to the formulation to reduce friction and prevent adhesion between the capsule content and the surfaces of the capsule filling equipment. The proper use of lubricants is essential in ensuring consistent…
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Potential Issues with Capsule Shell Disintegration Capsule shell disintegration is a critical factor in the dissolution and release of the active pharmaceutical ingredient (API) from the capsule. Disintegration issues can affect the drug’s bioavailability, therapeutic efficacy, and patient compliance. Several potential issues may arise with capsule shell disintegration, leading to problems with drug release. Here…
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Role of Excipients in Capsule Manufacturing Excipients play a vital role in capsule manufacturing as they are inactive ingredients used alongside the active pharmaceutical ingredient (API) to facilitate the formulation process, enhance drug delivery, and improve the overall performance of the capsules. Excipients serve several important functions that contribute to the quality, stability, and bioavailability…
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Formulation and Manufacturing of Sustained-Release Capsules Sustained-release capsules, also known as extended-release or controlled-release capsules, are designed to release the active pharmaceutical ingredient (API) gradually over an extended period, providing a steady and prolonged therapeutic effect. The formulation and manufacturing of sustained-release capsules require specialized techniques and excipients to achieve the desired release profile. Here’s…
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Process of Dry Powder Filling in Capsule Production Dry powder filling is a common method used in capsule production to fill capsules with powdered or granulated materials, including active pharmaceutical ingredients (APIs) and excipients. The process involves several steps to ensure accurate and uniform filling of the capsules. Here’s a detailed explanation of the dry…
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Optimizing Capsule Formulations for Better Bioavailability Achieving better bioavailability in capsule formulations is a critical goal in pharmaceutical development. Bioavailability refers to the extent and rate at which the active pharmaceutical ingredient (API) in a capsule is absorbed into the bloodstream and becomes available for therapeutic action. Several strategies can be employed to optimize capsule…
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Preparation of Enteric-Coated Capsules Enteric-coated capsules are designed to resist disintegration and dissolution in the acidic environment of the stomach. Instead, they disintegrate and release their contents in the more alkaline environment of the small intestine. The enteric coating helps protect sensitive drugs from degradation in the stomach and allows for targeted drug release. Here’s…
Filling Process for Soft Gelatin Capsules Soft gelatin capsules (SGC) are popular dosage forms used to deliver liquid or semi-solid formulations. The filling process for soft gelatin capsules involves several steps to ensure accurate dosing and uniformity in each capsule. Below, is a typical process of filling soft gelatin capsules: 1. Gelatin Shell Preparation The…
Types of Capsule Shells Used in Manufacturing Capsules are popular pharmaceutical dosage forms used to encapsulate and deliver medications. There are two main types of capsule shells used in manufacturing, each with its unique properties and applications. 1. Hard Gelatin Capsules Hard gelatin capsules (HGC) are the most commonly used type of capsules in the…
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Standardization and Classification of Capsule Sizes Capsules come in various sizes, each designed to hold different quantities of active pharmaceutical ingredients (APIs) and excipients. Standardization and classification of capsule sizes ensure uniformity in the pharmaceutical industry, making it easier for manufacturers and healthcare professionals to prescribe and dispense medications. Standardization of Capsule Sizes Capsule sizes…
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Advantages of Capsules vs. Tablets Capsules and tablets are two common pharmaceutical dosage forms used to deliver medications. Each has its unique advantages depending on the formulation and the specific needs of the patients. Below is a comparison table highlighting the advantages of using capsules over tablets in certain formulations: Advantages Capsules Tablets 1. Dosage…
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Process of Capsule Sealing and Banding Capsule sealing and banding are essential steps in the capsule manufacturing process. After the capsules are filled with the active pharmaceutical ingredient (API) and any additional excipients, sealing ensures that the capsule contents remain intact and protected until the capsule is ingested. In some cases, banding may be applied…
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