Tag: Manufacturing Troubleshooting

Addressing Over-Drying in Sugar-Coated Tablets During Curing

March 27, 2025 Admin

Addressing Over-Drying in Sugar-Coated Tablets During Curing Addressing Over-Drying in Sugar-Coated Tablets During Curing Introduction: Sugar-coating is an essential phase in the production of tablets, offering not only aesthetic appeal but also protection from environmental factors. However, one of the prevalent challenges during the sugar-coating process is over-drying, which can compromise the integrity and effectiveness…

Solid Dosage form, Tablets

Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production

March 27, 2025 Admin

Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production Managing Over-Sensitivity to Humidity in Hygroscopic Tablets During Production Introduction: Hygroscopic tablets are an essential component of the pharmaceutical industry, offering a convenient and effective means of delivering medication to patients. However, their production poses significant challenges due to their sensitivity to humidity. Excess moisture can…

Solid Dosage form, Tablets

Problems with ensuring consistent nitrogen distribution for capsule production.

March 21, 2025 Admin

Problems with ensuring consistent nitrogen distribution for capsule production. Problems with ensuring consistent nitrogen distribution for capsule production. Introduction: In the pharmaceutical industry, the production of solid oral dosage forms such as capsules is a complex process that requires meticulous attention to detail. Among the various factors that influence capsule quality, the consistent distribution of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Hardness Variability in High-Speed Compression Tablets

March 20, 2025 Admin

Managing Hardness Variability in High-Speed Compression Tablets Managing Hardness Variability in High-Speed Compression Tablets Introduction: In the pharmaceutical industry, tablets are a widely used solid dosage form, offering convenience in administration and precise dosing. However, ensuring the consistency of tablet hardness, especially during high-speed compression, is a critical quality attribute that directly impacts the dissolution…

Solid Dosage form, Tablets

Troubleshooting Failures in Residual Solvent Management for Compressed Air Systems

March 16, 2025 Admin

Troubleshooting Failures in Residual Solvent Management for Compressed Air Systems Troubleshooting Failures in Residual Solvent Management for Compressed Air Systems Introduction: Residual solvents are a crucial concern in pharmaceutical manufacturing, particularly when it comes to ensuring the safety and efficacy of solid dosage forms like tablets. Compressed air systems, often used in the production process,…

Solid Dosage form, Tablets

Validating Process Controls for High-Speed Granulation Equipment

March 16, 2025 Admin

Validating Process Controls for High-Speed Granulation Equipment Validating Process Controls for High-Speed Granulation Equipment Introduction: In the pharmaceutical industry, granulation is a critical process step in the production of solid dosage forms like tablets. High-speed granulation equipment is favored for its efficiency and capability to produce uniform granules, essential for consistent tablet quality. However, ensuring…

Solid Dosage form, Tablets

Inadequate systems for monitoring capsule fill weight variations during long-term storage.

March 16, 2025 Admin

Inadequate systems for monitoring capsule fill weight variations during long-term storage. Inadequate Systems for Monitoring Capsule Fill Weight Variations During Long-Term Storage Introduction: In the pharmaceutical industry, ensuring the quality and consistency of solid oral dosage forms, particularly capsules, is crucial. Capsules, whether hard or soft gelatin, are popular due to their ease of administration…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets

March 15, 2025 Admin

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Introduction: In the realm of pharmaceutical manufacturing, roller compaction is a critical granulation method frequently employed for the production of large-scale tablets. This process is favored for its ability to handle heat and moisture-sensitive compounds without requiring…

Solid Dosage form, Tablets

Managing Failures in Weight Uniformity Tests for High-Speed Compression

March 15, 2025 Admin

Managing Failures in Weight Uniformity Tests for High-Speed Compression Managing Failures in Weight Uniformity Tests for High-Speed Compression Introduction: The pharmaceutical industry is ever-evolving, with the demand for high-quality and efficient production processes constantly on the rise. High-speed compression in tablet manufacturing is a critical process, crucial for meeting market demands and ensuring patient safety….

Solid Dosage form, Tablets

Difficulty in ensuring consistent performance of capsule sealing equipment.

March 14, 2025 Admin

Difficulty in ensuring consistent performance of capsule sealing equipment. Difficulty in ensuring consistent performance of capsule sealing equipment. Introduction: In the pharmaceutical industry, the use of capsules as a dosage form is widespread due to their ease of production, patient compliance, and ability to encapsulate a variety of drugs. The capsule sealing process is a…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Residual Solvent Issues in Sugar-Coated Tablets

March 12, 2025 Admin

Troubleshooting Residual Solvent Issues in Sugar-Coated Tablets Troubleshooting Residual Solvent Issues in Sugar-Coated Tablets Introduction: The pharmaceutical industry is continuously advancing, with an emphasis on improving the quality and safety of its products. One of the critical areas of focus is the formulation and manufacturing of solid dosage forms, particularly sugar-coated tablets. These tablets are…

Solid Dosage form, Tablets

Poor validation of capsule weight variation for oil-based fills.

March 10, 2025 Admin

Poor validation of capsule weight variation for oil-based fills. Poor validation of capsule weight variation for oil-based fills Introduction: In the pharmaceutical industry, the production of capsules, especially those containing oil-based fills, presents unique challenges. Capsules are a preferred solid oral dosage form due to their versatility and ability to deliver precise doses of medication….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms