Tag: Manufacturing Challenges

Poor standardization of capsule defect classification criteria.

March 13, 2025 Admin

Poor standardization of capsule defect classification criteria. Poor standardization of capsule defect classification criteria. Introduction: In the pharmaceutical industry, capsules serve as a popular solid oral dosage form due to their ease of administration and ability to encapsulate a wide range of active pharmaceutical ingredients. However, the lack of standardized criteria for classifying capsule defects…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in achieving uniform distribution of capsules within packs.

March 13, 2025 Admin

Difficulty in achieving uniform distribution of capsules within packs. Difficulty in Achieving Uniform Distribution of Capsules within Packs Introduction: The pharmaceutical industry is continually evolving, driven by the need to ensure product efficacy, safety, and consumer satisfaction. Solid oral dosage forms, particularly capsules, are a staple in the industry due to their ease of administration…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Preventing Tablet Breakage During Blister Sealing for High-Speed Machines

March 12, 2025 Admin

Preventing Tablet Breakage During Blister Sealing for High-Speed Machines Preventing Tablet Breakage During Blister Sealing for High-Speed Machines Introduction: The pharmaceutical industry constantly aims to enhance the efficiency and reliability of drug production, particularly in the area of solid dosage forms like tablets. One critical aspect is the packaging process, where blister sealing plays a…

Solid Dosage form, Tablets

Controlling Powder Flow in Feed Frames for Film-Coated Tablets

March 10, 2025 Admin

Controlling Powder Flow in Feed Frames for Film-Coated Tablets Controlling Powder Flow in Feed Frames for Film-Coated Tablets Introduction: The pharmaceutical industry relies heavily on the production of solid dosage forms, with tablets being one of the most common. Ensuring consistent and reliable production of film-coated tablets requires precise control over several variables, one of…

Solid Dosage form, Tablets

Validating Adequacy of Binder Distribution in Compression Processes

March 9, 2025 Admin

Validating Adequacy of Binder Distribution in Compression Processes Validating Adequacy of Binder Distribution in Compression Processes Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms such as tablets is paramount. A critical aspect of this is the distribution of binders during the compression process. Binders play a key role in…

Solid Dosage form, Tablets

Real-Time Adjustment of Granulation Parameters for Uniformity

March 9, 2025 Admin

Real-Time Adjustment of Granulation Parameters for Uniformity Real-Time Adjustment of Granulation Parameters for Uniformity Introduction: In the pharmaceutical industry, the uniformity of granulation is critical for ensuring the quality and efficacy of solid dosage forms, particularly tablets. Granulation is a pivotal step in the tablet manufacturing process, where powder particles are aggregated to form granules….

Solid Dosage form, Tablets

Difficulty in detecting shell cracks during high-speed manufacturing.

March 9, 2025 Admin

Difficulty in detecting shell cracks during high-speed manufacturing. Difficulty in detecting shell cracks during high-speed manufacturing. Introduction: Capsules, both hard and soft gelatin, are among the most popular solid oral dosage forms in the pharmaceutical industry. Their wide acceptance is due to their versatility in delivering a variety of active pharmaceutical ingredients (APIs). However, the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Controlling Residual Solvent Levels in Coating Processes

March 9, 2025 Admin

Controlling Residual Solvent Levels in Coating Processes Controlling Residual Solvent Levels in Coating Processes Introduction: In the pharmaceutical industry, ensuring the quality and safety of solid dosage forms such as tablets is paramount. One critical aspect of this process is the control of residual solvent levels during tablet coating. Residual solvents, if not adequately managed,…

Solid Dosage form, Tablets

Inadequate systems for monitoring capsule integrity during validation.

March 9, 2025 Admin

Inadequate systems for monitoring capsule integrity during validation. Inadequate Systems for Monitoring Capsule Integrity During Validation Introduction: In the pharmaceutical industry, the integrity of capsules, whether hard or soft gelatin, is crucial for ensuring the efficacy and safety of the medication contained within. Monitoring capsule integrity during validation is an essential part of the manufacturing…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Reducing Rejection Rates in Automated Coating Processes

March 9, 2025 Admin

Reducing Rejection Rates in Automated Coating Processes Reducing Rejection Rates in Automated Coating Processes Introduction: The pharmaceutical industry is continuously evolving, with automation playing a pivotal role in enhancing efficiency and consistency in manufacturing processes. One critical aspect of tablet production is the coating process, which not only improves the aesthetic appeal of tablets but…

Solid Dosage form, Tablets

Managing Fines Generation in Fluid Bed Processing

March 9, 2025 Admin

Managing Fines Generation in Fluid Bed Processing Managing Fines Generation in Fluid Bed Processing Introduction: Fluid bed processing is a critical operation in pharmaceutical manufacturing, primarily utilized for drying, granulating, and coating purposes. Its efficiency and effectiveness in producing uniform and quality granules make it a preferred choice in tablet production. However, a persistent challenge…

Solid Dosage form, Tablets

Difficulty in validating cleaning procedures for equipment exposed to hygroscopic powders.

March 8, 2025 Admin

Difficulty in validating cleaning procedures for equipment exposed to hygroscopic powders. Difficulty in validating cleaning procedures for equipment exposed to hygroscopic powders. Introduction: In the pharmaceutical industry, ensuring the cleanliness of manufacturing equipment is paramount to maintaining product quality and safety. This task becomes particularly challenging when dealing with hygroscopic powders, which are prone to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms