Tag: Immediate-release tablets

Managing Granule Segregation During Drying and Milling How to Manage Granule Segregation During Drying and Milling What is Granule Segregation? Granule segregation refers to the separation of particles or granules based on size, density, or composition during processing steps such as drying and milling. Segregation can result in inconsistent granule properties, poor flowability, uneven drug…

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How to Prevent Over-Agglomeration in Fluidized Bed Granulators How to Prevent Over-Agglomeration in Fluidized Bed Granulators What is Over-Agglomeration in Fluidized Bed Granulation? Over-agglomeration refers to the excessive clumping of particles during the granulation process in a fluidized bed granulator. This issue can lead to oversized granules, poor flow properties, uneven drug distribution, and challenges…

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Troubleshooting Poor Binder Distribution in Wet Granulation Troubleshooting Poor Binder Distribution in Wet Granulation What is Poor Binder Distribution in Wet Granulation? Poor binder distribution occurs when the binder, used to ensure granule cohesiveness, is unevenly dispersed throughout the granulated material. This can lead to problems such as inconsistent granule size, weak granules, or excessive…

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How to Optimize Roller Compaction Parameters for Granule Uniformity How to Optimize Roller Compaction Parameters for Granule Uniformity What is Roller Compaction in Granulation? Roller compaction is a dry granulation process used to produce granules by compacting powder blends between two rollers. The resulting compacted ribbons are milled to form granules of the desired size….

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Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets Troubleshooting Adhesion Issues in Multi-Layer Coated Tablets What Are Adhesion Issues in Multi-Layer Coated Tablets? Adhesion issues occur when layers of coating in multi-layer tablets fail to bond properly. This can result in peeling, cracking, or delamination, compromising the tablet’s appearance, functionality, and drug release profile. Adhesion problems…

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How to Avoid Color Mottling in Film-Coated Tablets How to Prevent Color Mottling in Film-Coated Tablets What is Color Mottling in Film-Coated Tablets? Color mottling refers to uneven or patchy color distribution on the surface of film-coated tablets. This defect can negatively impact the aesthetic appeal and perceived quality of pharmaceutical products. Color mottling is…

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Managing Tablet Coating Thickness Variability Expert Guide to Managing Tablet Coating Thickness Variability What is Tablet Coating Thickness Variability? Coating thickness variability refers to inconsistencies in the thickness of the applied film across tablets in a batch. This can lead to issues such as uneven drug release, aesthetic defects, and non-compliance with regulatory standards. Managing…

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How to Ensure Batch-to-Batch Coating Consistency Step-by-Step Guide to Ensuring Batch-to-Batch Coating Consistency Why is Batch-to-Batch Coating Consistency Important? Batch-to-batch coating consistency is critical in pharmaceutical manufacturing to ensure product quality, compliance with regulatory standards, and patient safety. Consistency in coating prevents defects, maintains drug release profiles, and ensures uniform tablet appearance across production batches….

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Preventing Over-Wetting in Enteric Coating Processes Preventing Over-Wetting in Enteric Coating Processes What is Over-Wetting in Enteric Coating Processes? Over-wetting in enteric coating occurs when excessive spray or inadequate drying leads to an overly moist tablet bed. This condition results in defects such as sticking, clumping, peeling, or uneven coating. Preventing over-wetting is critical to…

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How to Use Advanced Coating Machines for Multi-Functional Tablets How to Effectively Use Advanced Coating Machines for Multi-Functional Tablets What are Multi-Functional Tablets? Multi-functional tablets are pharmaceutical dosage forms designed to deliver multiple therapeutic benefits through advanced formulations. These tablets may include combinations of controlled-release, immediate-release, or gastro-resistant layers, each requiring specific coating technologies to…

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Improving Drying Efficiency in Film Coating Processes Expert Guide to Improving Drying Efficiency in Film Coating Processes Why is Drying Efficiency Crucial in Film Coating? Drying efficiency is a critical factor in the film coating process, ensuring the proper application of coating solutions on tablet surfaces. Efficient drying prevents defects such as sticking, uneven coatings,…

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How to Prevent Orange Peel Effect in Coated Tablets Step-by-Step Guide to Preventing Orange Peel Effect in Coated Tablets What is the Orange Peel Effect in Coated Tablets? The orange peel effect refers to an uneven, rough, or dimpled texture on the surface of film-coated tablets. This defect resembles the skin of an orange and…

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