Tag: Granulation in tablet production​

Solubility Enhancers in Sustained Release Tablet Formulations Research & Trends: The Role of Solubility Enhancers in Sustained Release Tablet Formulations Overview: Solubility is a crucial factor in the design and development of pharmaceutical formulations. Many active pharmaceutical ingredients (APIs) exhibit poor solubility, which can negatively impact the bioavailability and therapeutic efficacy of a drug. This…

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Troubleshooting Formulation Issues in High-Dose Tablets Troubleshooting Formulation Issues in High-Dose Tablets Overview: High-dose tablets present unique challenges during the formulation process due to the large amounts of active pharmaceutical ingredients (APIs) involved. These tablets require careful consideration of excipient selection, tablet manufacturing processes, and regulatory compliance. Poor formulation can lead to issues such as…

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Role of Anti-Tacking Agents in Film-Coated Tablets Understanding the Role of Anti-Tacking Agents in Film-Coated Tablets Overview: Anti-tacking agents play a crucial role in the film coating process of tablets, helping to ensure smooth and efficient production by preventing the formation of unwanted sticky surfaces. These agents are particularly useful in film-coated tablet formulations where…

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Designing Enteric-Coated Tablets for Delayed Drug Release DIY and Step-by-Step Guide to Designing Enteric-Coated Tablets for Delayed Drug Release Overview: Enteric-coated tablets are designed to prevent the release of the active pharmaceutical ingredient (API) until the tablet reaches the small intestine. This delayed release mechanism is ideal for APIs that are sensitive to stomach acid,…

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Selecting Disintegration Aids for Sugar-Coated Tablets Tips and Tricks: Selecting Disintegration Aids for Sugar-Coated Tablets Overview: Disintegration aids are crucial in the formulation of sugar-coated tablets, as they facilitate the rapid breakdown of the tablet in the gastrointestinal tract. The sugar coating serves to protect the API, mask the taste, and provide aesthetic appeal, but…

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Role of Controlled Agglomeration in Granulation Processes Expert Guide: The Role of Controlled Agglomeration in Granulation Processes Overview: Controlled agglomeration is a crucial step in the granulation process, which plays an integral role in the production of tablets and other solid dosage forms. The technique involves the controlled formation of granules by binding fine particles…

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Strategies for Reducing Coating Time in Film-Coated Tablets Research & Trends: Strategies for Reducing Coating Time in Film-Coated Tablets Overview: Coating is a critical step in the tablet manufacturing process, especially for film-coated tablets, which require precise control over coating thickness, uniformity, and quality. However, coating can be a time-consuming process, and reducing coating time…

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Addressing Tablet Erosion in Controlled Release Formulations How to Address Tablet Erosion in Controlled Release Formulations Overview: Tablet erosion is a common issue in controlled release (CR) tablet formulations, where the tablet erodes too quickly or inconsistently during the release process. This can lead to a burst release of the active pharmaceutical ingredient (API), causing…

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Incorporating Nutraceuticals in Immediate Release Tablets: Challenges Case Study: Overcoming Challenges in Incorporating Nutraceuticals in Immediate Release Tablets Overview: Incorporating nutraceuticals into pharmaceutical formulations, particularly in immediate release (IR) tablets, presents several challenges. Nutraceuticals, which include dietary supplements, vitamins, minerals, and herbal extracts, often have different physicochemical properties than conventional APIs. These differences can make…

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Excipient-Drug Interaction Studies in Extended Release Tablets A Step-by-Step Guide to Excipient-Drug Interaction Studies in Extended Release Tablets Overview: Excipient-drug interactions are a crucial consideration in the development of extended release (ER) tablets. The selection of excipients, including binders, fillers, disintegrants, and polymers, can significantly affect the release profile of the active pharmaceutical ingredient (API)….

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Role of Pre-Formulation Studies in Tablet Development The Importance of Pre-Formulation Studies in Tablet Development Overview: Pre-formulation studies are a critical phase in the development of pharmaceutical tablets. These studies involve assessing the physical and chemical properties of the active pharmaceutical ingredient (API) and excipients, which serve as the foundation for successful tablet formulation. The…

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Strategies to Minimize Friability in Tablets During Development Effective Strategies to Minimize Friability in Tablets During Development Overview: Friability is a critical factor in tablet formulation, referring to the tendency of tablets to break or crumble under stress during handling, transport, and storage. A high friability rate indicates poor tablet strength and can lead to…

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