Tag: GMP guidelines

Ensuring Adequate Calibration of Equipment in Coating Processes

March 12, 2025 Admin

Ensuring Adequate Calibration of Equipment in Coating Processes Ensuring Adequate Calibration of Equipment in Coating Processes Introduction: In the pharmaceutical industry, the coating of tablets is a critical process that not only enhances the aesthetic appeal of the product but also plays a vital role in controlling the release profile of the active pharmaceutical ingredient…

Solid Dosage form, Tablets

Managing Failures in Moisture Content Tests for Hygroscopic APIs

March 11, 2025 Admin

Managing Failures in Moisture Content Tests for Hygroscopic APIs Managing Failures in Moisture Content Tests for Hygroscopic APIs Introduction: In the pharmaceutical industry, Active Pharmaceutical Ingredients (APIs) form the backbone of drug manufacturing. Among these, hygroscopic APIs present unique challenges due to their inherent ability to absorb moisture from the environment. Accurate moisture content testing…

Solid Dosage form, Tablets

Inadequate systems for monitoring capsule integrity during production.

March 11, 2025 Admin

Inadequate systems for monitoring capsule integrity during production. Inadequate systems for monitoring capsule integrity during production. Introduction: The pharmaceutical industry continuously strives to ensure the highest quality of its products, and capsule integrity plays a crucial role in this process. Capsules, whether hard or soft gelatin, are a popular solid oral dosage form, valued for…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Controlling Spray Gun Settings for Even Coating Distribution

March 11, 2025 Admin

Controlling Spray Gun Settings for Even Coating Distribution Controlling Spray Gun Settings for Even Coating Distribution Introduction: The pharmaceutical industry constantly seeks to enhance the quality and efficacy of its products, and tablet coating is a critical aspect of achieving these goals. Coating tablets not only improves their aesthetic appeal but also plays vital roles…

Solid Dosage form, Tablets

Preventing Tablet Capping During High-Speed Compression

March 11, 2025 Admin

Preventing Tablet Capping During High-Speed Compression Preventing Tablet Capping During High-Speed Compression Introduction: The pharmaceutical industry is ever-evolving, with technological advancements pushing the boundaries of speed and efficiency in drug manufacturing. Tablets, as a prevalent solid dosage form, are at the forefront of this evolution. However, with high-speed compression, challenges such as tablet capping can…

Solid Dosage form, Tablets

Managing Failure in Moisture Content Tests for Hygroscopic Tablets

March 10, 2025 Admin

Managing Failure in Moisture Content Tests for Hygroscopic Tablets Managing Failure in Moisture Content Tests for Hygroscopic Tablets Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of medicinal products is paramount. Hygroscopic tablets, which are prone to absorbing moisture from the environment, present unique challenges in this regard. Moisture content tests are critical…

Solid Dosage form, Tablets

Challenges in Binder Addition During Granulation

March 9, 2025 Admin

Challenges in Binder Addition During Granulation Challenges in Binder Addition During Granulation Introduction: In the pharmaceutical industry, granulation is a crucial process in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form larger entities known as granules. One of the most critical components in the granulation…

Solid Dosage form, Tablets

Troubleshooting Failures in Humidity Control for Compression Equipment Areas

March 8, 2025 Admin

Troubleshooting Failures in Humidity Control for Compression Equipment Areas Troubleshooting Failures in Humidity Control for Compression Equipment Areas Introduction: In the pharmaceutical industry, maintaining precise environmental control in manufacturing areas is crucial, especially in compression equipment zones used for tablet production. Humidity control is a significant aspect of this environment, as fluctuations can lead to…

Solid Dosage form, Tablets

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes

March 7, 2025 Admin

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Introduction: In the pharmaceutical industry, coated tablets are among the most common solid dosage forms due to their advantages in masking unpleasant tastes, improving stability, and controlling drug release. However, the process of coating tablets can be highly sensitive…

Solid Dosage form, Tablets

Preventing Seal Adhesion Failures in High-Speed Packaging Machines

March 6, 2025 Admin

Preventing Seal Adhesion Failures in High-Speed Packaging Machines Preventing Seal Adhesion Failures in High-Speed Packaging Machines Introduction: In the competitive world of pharmaceutical manufacturing, ensuring the integrity of packaging is paramount. High-speed packaging machines are the backbone of pharmaceutical production, ensuring that tablets and other solid dosage forms are securely packaged for distribution. However, one…

Solid Dosage form, Tablets

Addressing Cross-Contamination Risks in Purified Water Systems for Multi-API Tablets

March 5, 2025 Admin

Addressing Cross-Contamination Risks in Purified Water Systems for Multi-API Tablets Addressing Cross-Contamination Risks in Purified Water Systems for Multi-API Tablets Introduction: In the pharmaceutical industry, the production of multi-Active Pharmaceutical Ingredient (API) tablets poses unique challenges, particularly concerning cross-contamination. Purified water systems play a pivotal role in tablet manufacturing, serving as a critical utility in…

Solid Dosage form, Tablets

Troubleshooting Spray Pattern Irregularities in Coating Machines

March 4, 2025 Admin

Troubleshooting Spray Pattern Irregularities in Coating Machines Troubleshooting Spray Pattern Irregularities in Coating Machines Introduction: In the pharmaceutical industry, the coating of tablets is a critical process that impacts the efficacy, stability, and aesthetic appeal of the final product. Coating machines are complex pieces of equipment designed to apply a uniform layer of coating material…

Solid Dosage form, Tablets