Tag: gelatin stability

Challenges in ensuring consistent gelatin solution pH during production.

May 1, 2025 Admin

Challenges in ensuring consistent gelatin solution pH during production. Challenges in ensuring consistent gelatin solution pH during production. Introduction: In the pharmaceutical industry, the production of capsules, specifically those made of gelatin, is a meticulous process that requires precise control over various parameters. Among these, maintaining a consistent pH level in gelatin solutions is crucial….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in predicting the impact of high humidity on capsule disintegration times.

April 30, 2025 Admin

Challenges in predicting the impact of high humidity on capsule disintegration times. Challenges in predicting the impact of high humidity on capsule disintegration times. Introduction: In the realm of pharmaceutical manufacturing, ensuring the efficacy and stability of solid oral dosage forms such as capsules is paramount. Capsules, both hard and soft gelatin, are a prevalent…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring consistent gelatin viscosity during preparation.

April 29, 2025 Admin

Difficulty in ensuring consistent gelatin viscosity during preparation. Difficulty in Ensuring Consistent Gelatin Viscosity During Preparation Introduction: In the pharmaceutical industry, ensuring the consistent viscosity of gelatin during the preparation of capsules is crucial. Gelatin is a key component in both hard and soft gelatin capsules, which are popular solid oral dosage forms due to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of capsule disintegration profiles for capsules stored under stressed conditions.

April 11, 2025 Admin

Poor validation of capsule disintegration profiles for capsules stored under stressed conditions. Poor validation of capsule disintegration profiles for capsules stored under stressed conditions. Introduction: In the pharmaceutical industry, ensuring the effective disintegration of capsules is crucial for the drug’s efficacy and safety. Disintegration testing is an essential quality control measure that determines whether capsules…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in preventing capsule discoloration during vacuum packaging.

April 10, 2025 Admin

Difficulty in preventing capsule discoloration during vacuum packaging. Difficulty in Preventing Capsule Discoloration During Vacuum Packaging Introduction: Capsule discoloration during vacuum packaging is a persistent challenge faced by pharmaceutical manufacturers. This phenomenon not only affects the aesthetic value of the product but can also indicate compromised product stability. Maintaining the integrity and appearance of capsules…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in monitoring gelatin drying profiles.

April 6, 2025 Admin

Poor reproducibility in monitoring gelatin drying profiles. Poor reproducibility in monitoring gelatin drying profiles. Introduction: Gelatin capsules, both hard and soft, serve as a crucial delivery system for pharmaceuticals, offering benefits such as ease of administration and enhanced bioavailability. However, the manufacturing process of these capsules, particularly the drying phase, presents significant challenges. Poor reproducibility…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in gelatin cross-linking data under various storage conditions.

April 4, 2025 Admin

Poor reproducibility in gelatin cross-linking data under various storage conditions. Poor Reproducibility in Gelatin Cross-Linking Data Under Various Storage Conditions Introduction: In the pharmaceutical industry, the stability and integrity of solid oral dosage forms, particularly capsules, are paramount. Gelatin, a common excipient used in hard and soft capsules, undergoes a process known as cross-linking, which…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for detecting capsule discoloration under light exposure.

March 4, 2025 Admin

Inadequate systems for detecting capsule discoloration under light exposure. Inadequate systems for detecting capsule discoloration under light exposure. Introduction: Capsules, both hard and soft gelatin, are one of the most popular solid oral dosage forms in the pharmaceutical industry. However, they are not immune to challenges that can affect their quality and efficacy. One such…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring gelatin cross-linking during validation.

March 3, 2025 Admin

Inadequate systems for monitoring gelatin cross-linking during validation. Inadequate systems for monitoring gelatin cross-linking during validation. Introduction: Gelatin capsules, both hard and soft gelatin, are widely used in the pharmaceutical industry due to their versatility and patient compliance benefits. However, one of the key challenges faced during the formulation and manufacturing of gelatin capsules is…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms