Tag: Gelatin capsules

Difficulty in Formulating Capsules with Delayed-Release Coating Addressing the Difficulty in Formulating Capsules with Delayed-Release Coating Context Delayed-release capsules are designed to release their active pharmaceutical ingredient (API) after a specified period of time or under specific conditions, such as in the small intestine rather than the stomach. This is particularly useful for drugs that…

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Variability in Shell Integrity Due to Environmental Factors Addressing Variability in Shell Integrity Due to Environmental Factors Context The integrity of capsule shells is critical for maintaining the stability and performance of pharmaceutical products. Capsules are sensitive to various environmental factors, such as temperature, humidity, and storage conditions, which can impact their physical properties. These…

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Difficulty in Designing Bioequivalent Formulations for Generic Capsules Addressing the Difficulty in Designing Bioequivalent Formulations for Generic Capsules Context Bioequivalence is a critical consideration in the development of generic drug formulations. For a generic drug to be considered equivalent to its branded counterpart, it must demonstrate that the rate and extent of absorption of the…

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Problems with Shell Discoloration Due to Excipients Interactions Addressing Problems with Shell Discoloration Due to Excipients Interactions Context Discoloration of capsule shells is a common issue encountered during the development and storage of pharmaceutical products. This problem can arise from interactions between the capsule shell material (such as gelatin or HPMC) and the excipients used…

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Inadequate Data on Drug Release Kinetics During Development Addressing Inadequate Data on Drug Release Kinetics During Development Context One of the most critical aspects of pharmaceutical formulation development is understanding the drug release kinetics to ensure consistent therapeutic efficacy and safety. However, inadequate data on drug release kinetics during the early stages of formulation development…

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Limited Options for Plasticizers Suitable for Pharmaceutical-Grade Gelatin Addressing the Limited Options for Plasticizers Suitable for Pharmaceutical-Grade Gelatin Context Plasticizers are essential in the production of gelatin capsules, as they improve the flexibility, ease of processing, and stability of the capsule shell. However, the number of plasticizers that are suitable for use in pharmaceutical-grade gelatin…

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Challenges in Encapsulating Sticky Powders in Hard Gelatin Capsules Addressing Challenges in Encapsulating Sticky Powders in Hard Gelatin Capsules Context Encapsulating sticky powders into hard gelatin capsules can be a significant challenge in pharmaceutical manufacturing. Sticky powders tend to form clumps or agglomerates, making it difficult to ensure uniform fill weights and proper capsule filling….

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High Excipient-to-Drug Ratio Required for Certain Formulations Addressing the High Excipient-to-Drug Ratio Required for Certain Formulations Context In pharmaceutical formulations, particularly for low-dose drugs, achieving the desired therapeutic effect can often require the use of a large volume of excipients in the final dosage form. This leads to a high excipient-to-drug ratio, which can result…

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Difficulty in Developing Formulations for Immediate-Release Soft Gelatin Capsules Addressing the Difficulty in Developing Formulations for Immediate-Release Soft Gelatin Capsules Context Immediate-release (IR) soft gelatin capsules are widely used in the pharmaceutical industry for delivering APIs that need to be released and absorbed quickly for therapeutic efficacy. However, formulating IR soft gelatin capsules can be…

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Incompatibility of Capsule Formulation with Shell Cross-Linking Inhibitors Addressing Incompatibility of Capsule Formulation with Shell Cross-Linking Inhibitors Context The formulation of capsules, particularly soft gelatin capsules, requires careful selection of excipients and materials to ensure compatibility and stability. One challenge that arises is the potential incompatibility between the capsule shell and certain cross-linking inhibitors or…

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Poor Stability of Encapsulated Oils over Product Shelf Life Addressing Poor Stability of Encapsulated Oils over Product Shelf Life Context Encapsulated oils are commonly used in pharmaceutical formulations due to their ability to deliver active ingredients, such as vitamins, omega-3 fatty acids, or essential oils, in a stable and controlled manner. However, oils are highly…

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Poor Flowability of Powders Leading to Encapsulation Issues Addressing Poor Flowability of Powders Leading to Encapsulation Issues Context The flowability of powders plays a critical role in the manufacturing of capsule formulations, particularly in achieving uniformity in fill weight and ensuring consistent dissolution and bioavailability. Poor flowability of powder blends can lead to inconsistent filling…

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