Tag: Gelatin capsules

Limited Options for Solvents Suitable for Soft Gelatin Capsules

May 1, 2025 Admin

Limited Options for Solvents Suitable for Soft Gelatin Capsules Overcoming the Challenge of Limited Solvent Options for Soft Gelatin Capsules Context In pharmaceutical dosage form manufacturing, one of the challenges faced in the production of soft gelatin capsules is selecting the right solvent for dissolving or suspending the active pharmaceutical ingredient (API). The solvents used…

Capsules (Hard & Soft Gelatin)

Sensitivity of the Drug to Moisture Affecting Capsule Integrity

May 1, 2025 Admin

Sensitivity of the Drug to Moisture Affecting Capsule Integrity How Moisture Sensitivity of Drugs Affects Capsule Integrity and Solutions to Overcome It Context Moisture sensitivity of active pharmaceutical ingredients (APIs) can lead to significant challenges in capsule dosage form manufacturing, especially in soft gelatin capsules. Moisture absorption can compromise the structural integrity of the gelatin…

Capsules (Hard & Soft Gelatin)

Incompatibility of Active Ingredients with Gelatin Shell Materials

May 1, 2025 Admin

Incompatibility of Active Ingredients with Gelatin Shell Materials Addressing the Incompatibility Between Active Ingredients and Gelatin Shell Materials in Capsules Context In the pharmaceutical industry, the incompatibility between active pharmaceutical ingredients (APIs) and gelatin shell materials is a significant challenge in capsule formulation. This issue typically arises in the production of soft gelatin capsules, where…

Capsules (Hard & Soft Gelatin)

Difficulty in Achieving Uniform Drug Distribution within Capsule Fill Material

May 1, 2025 Admin

Difficulty in Achieving Uniform Drug Distribution within Capsule Fill Material Challenges in Ensuring Uniform Drug Distribution in Capsule Fill Material Context In pharmaceutical dosage form manufacturing, particularly during capsule filling, uniform drug distribution is a critical issue. This problem is encountered during the formulation of both hard and soft gelatin capsules, where ensuring consistent drug…

Capsules (Hard & Soft Gelatin)

High rejection rates due to improper alignment of capsule compartments.

April 30, 2025 Admin

High rejection rates due to improper alignment of capsule compartments. High Rejection Rates Due to Improper Alignment of Capsule Compartments Introduction: In the pharmaceutical industry, the production of solid oral dosage forms, particularly capsules, is a critical process that requires precision and accuracy. Capsules, whether hard or soft gelatin, are a popular choice for delivering…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in predicting the impact of high humidity on capsule disintegration times.

April 30, 2025 Admin

Challenges in predicting the impact of high humidity on capsule disintegration times. Challenges in predicting the impact of high humidity on capsule disintegration times. Introduction: In the realm of pharmaceutical manufacturing, ensuring the efficacy and stability of solid oral dosage forms such as capsules is paramount. Capsules, both hard and soft gelatin, are a prevalent…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in dissolution profiles for lipid-based capsules.

April 24, 2025 Admin

Poor reproducibility in dissolution profiles for lipid-based capsules. Poor reproducibility in dissolution profiles for lipid-based capsules. Introduction: Lipid-based capsules, encompassing both hard and soft gelatin varieties, are critical in the delivery of poorly water-soluble drugs. These formulations improve bioavailability, allowing for efficient drug release and absorption. However, achieving consistent dissolution profiles in lipid-based capsules poses…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule integrity for long-term storage conditions.

April 23, 2025 Admin

Difficulty in validating capsule integrity for long-term storage conditions. Difficulty in validating capsule integrity for long-term storage conditions. Introduction: In the pharmaceutical industry, ensuring the integrity of capsules over their shelf life is paramount. Capsules, whether hard or soft gelatin, are a preferred dosage form due to their ease of administration and ability to encapsulate…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule sealing for high-viscosity formulations.

April 23, 2025 Admin

Difficulty in validating capsule sealing for high-viscosity formulations. Difficulty in Validating Capsule Sealing for High-Viscosity Formulations Introduction: In the pharmaceutical industry, the development and manufacturing of solid oral dosage forms, specifically capsules, play a crucial role in delivering medications effectively to patients. Capsules, particularly those filled with high-viscosity formulations, present unique challenges in sealing validation….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule weight loss due to evaporation.

April 23, 2025 Admin

Inadequate systems for monitoring capsule weight loss due to evaporation. Inadequate Systems for Monitoring Capsule Weight Loss Due to Evaporation Introduction: Capsules, both hard and soft gelatin, are among the most popular solid oral dosage forms in the pharmaceutical industry, renowned for their ease of administration and ability to encapsulate a wide range of formulations….

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating capsule inspection machines for transparent capsules.

April 23, 2025 Admin

Challenges in validating capsule inspection machines for transparent capsules. Challenges in Validating Capsule Inspection Machines for Transparent Capsules Introduction: In the pharmaceutical industry, solid oral dosage forms like capsules are crucial due to their ease of use and precise dosing capabilities. Among these, transparent capsules have gained popularity because they allow consumers and healthcare professionals…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in evaluating the stability of multi-particulate capsules.

April 23, 2025 Admin

Difficulty in evaluating the stability of multi-particulate capsules. Difficulty in evaluating the stability of multi-particulate capsules Introduction: In the pharmaceutical industry, ensuring the stability of drug products is crucial for maintaining their efficacy, safety, and quality over their shelf life. Multi-particulate capsules, which contain numerous small, discrete particles within a single dosage form, offer several…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms