Tag: formulation stability

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies

May 3, 2025 Admin

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Introduction: In the realm of pharmaceuticals, ensuring consistency in the disintegration time of tablets during long-term stability studies is pivotal for guaranteeing a drug’s efficacy, safety, and patient compliance. Disintegration time is a critical quality attribute that…

Solid Dosage form, Tablets

Problems with maintaining uniform mixing of lipid-based formulations.

April 21, 2025 Admin

Problems with maintaining uniform mixing of lipid-based formulations. Problems with maintaining uniform mixing of lipid-based formulations Introduction: Lipid-based formulations have garnered significant attention in the pharmaceutical industry due to their ability to enhance the solubility and bioavailability of poorly water-soluble drugs. These formulations utilize lipids as carriers, which can improve drug absorption and provide a…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in assessing the stability of capsules containing low-dose APIs.

April 21, 2025 Admin

Difficulty in assessing the stability of capsules containing low-dose APIs. Difficulty in assessing the stability of capsules containing low-dose APIs. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount, particularly when dealing with capsules containing low-dose Active Pharmaceutical Ingredients (APIs). Stability refers to the ability of a drug product to maintain…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in assay testing for encapsulated suspensions.

April 18, 2025 Admin

Poor reproducibility in assay testing for encapsulated suspensions. Poor reproducibility in assay testing for encapsulated suspensions. Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of drug products is paramount. Encapsulated suspensions, particularly in the form of hard and soft gelatin capsules, present unique challenges in maintaining consistent assay results. Assay testing is critical…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with detecting changes in gelatin plasticizer levels during stability testing.

April 16, 2025 Admin

Problems with detecting changes in gelatin plasticizer levels during stability testing. Problems with Detecting Changes in Gelatin Plasticizer Levels During Stability Testing Introduction: In the pharmaceutical industry, solid oral dosage forms, particularly gelatin capsules, are prevalent due to their ease of use and patient compliance. However, maintaining the stability of these dosage forms is critical…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies.

April 9, 2025 Admin

Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies. Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies. Introduction: In the realm of pharmaceuticals, the dissolution testing of capsules is a critical parameter in ensuring the efficacy and safety of drug products. Evaluating capsule dissolution in biorelevant media during…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating equipment for encapsulating semi-solid formulations.

April 8, 2025 Admin

Challenges in validating equipment for encapsulating semi-solid formulations. Challenges in validating equipment for encapsulating semi-solid formulations. Introduction: In the pharmaceutical industry, the encapsulation of semi-solid formulations presents unique challenges that require precise validation to ensure product efficacy and safety. Semi-solid formulations, often used for their controlled release properties and enhanced bioavailability, demand stringent equipment validation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent gelatin plasticizer levels during validation.

April 2, 2025 Admin

Problems with ensuring consistent gelatin plasticizer levels during validation. Problems with Ensuring Consistent Gelatin Plasticizer Levels During Validation Introduction: The pharmaceutical industry faces numerous challenges when it comes to the formulation and validation of solid oral dosage forms, particularly capsules. Among these challenges, ensuring consistent gelatin plasticizer levels is critical in maintaining the quality and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in ensuring consistent capsule transparency for high-oil formulations.

March 27, 2025 Admin

Challenges in ensuring consistent capsule transparency for high-oil formulations. Challenges in Ensuring Consistent Capsule Transparency for High-Oil Formulations Introduction: In the pharmaceutical industry, the transparency of capsules is not merely an aesthetic feature but a critical quality attribute that can impact consumer perception and product acceptance. High-oil formulations, frequently used for their therapeutic benefits and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of capsule transparency for certain formulations.

March 25, 2025 Admin

Poor validation of capsule transparency for certain formulations. Poor validation of capsule transparency for certain formulations. Introduction: In the pharmaceutical industry, the transparency of capsules, especially gelatin-based ones, plays a critical role in both consumer perception and regulatory compliance. The visual clarity of capsules can affect patient trust, as transparency often signifies purity and lack…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in maintaining uniform gelatin solution pH.

March 16, 2025 Admin

Difficulty in maintaining uniform gelatin solution pH. Difficulty in Maintaining Uniform Gelatin Solution pH Introduction: In the pharmaceutical industry, maintaining the uniformity of gelatin solution pH is crucial for the production of high-quality hard and soft gelatin capsules. These capsules are widely used due to their ease of administration and ability to mask unpleasant tastes…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles

March 15, 2025 Admin

Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles Addressing Brittleness in Sugar-Coated Tablets Under Freeze-Thaw Cycles Introduction: Sugar-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their aesthetic appeal and ability to mask the taste of active pharmaceutical ingredients (APIs). However, the stability of these tablets can be significantly challenged…

Solid Dosage form, Tablets