Tag: formulation science

Troubleshooting Brittleness Failures in Immediate Release Tablets

March 21, 2025 Admin

Troubleshooting Brittleness Failures in Immediate Release Tablets Troubleshooting Brittleness Failures in Immediate Release Tablets Introduction: Immediate release tablets represent a significant portion of the pharmaceutical market due to their convenience and effectiveness in delivering medication rapidly. However, brittleness failures in these tablets can pose substantial challenges, affecting their integrity and therapeutic efficacy. Brittleness, often resulting…

Solid Dosage form, Tablets

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time

March 14, 2025 Admin

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Introduction: The development of sustained release tablets represents a significant advancement in pharmaceutical technology, aiming to provide consistent therapeutic effects over extended periods. These formulations are essential for enhancing patient compliance, minimizing dosing…

Solid Dosage form, Tablets

Addressing Heat Sensitivity of APIs During Validation of Coated Tablets

March 10, 2025 Admin

Addressing Heat Sensitivity of APIs During Validation of Coated Tablets Addressing Heat Sensitivity of APIs During Validation of Coated Tablets Introduction: The pharmaceutical industry continuously strives to enhance the efficacy, stability, and safety of drug products. One of the critical aspects of drug formulation is the management of active pharmaceutical ingredients (APIs) that exhibit sensitivity…

Solid Dosage form, Tablets

Challenges in Binder Addition During Granulation

March 9, 2025 Admin

Challenges in Binder Addition During Granulation Challenges in Binder Addition During Granulation Introduction: In the pharmaceutical industry, granulation is a crucial process in the production of solid dosage forms such as tablets. It involves the agglomeration of powder particles to form larger entities known as granules. One of the most critical components in the granulation…

Solid Dosage form, Tablets

Preventing Non-Uniform API Distribution in Multi-API Tablets

March 8, 2025 Admin

Preventing Non-Uniform API Distribution in Multi-API Tablets Preventing Non-Uniform API Distribution in Multi-API Tablets Introduction: In the intricate world of pharmaceutical manufacturing, ensuring the uniform distribution of Active Pharmaceutical Ingredients (APIs) within multi-API tablets is crucial. These tablets are essential for delivering multiple therapeutic effects simultaneously, often improving patient compliance. However, achieving uniform API distribution…

Solid Dosage form, Tablets

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes

March 8, 2025 Admin

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Introduction: The pharmaceutical industry relies heavily on the integrity and efficacy of solid dosage forms like tablets. Among these, sugar-coated tablets have been traditionally used for their aesthetic appeal and ability to mask unpleasant tastes. However, the…

Solid Dosage form, Tablets

Controlling Binder Distribution in Wet Granulation Processes

March 7, 2025 Admin

Controlling Binder Distribution in Wet Granulation Processes Controlling Binder Distribution in Wet Granulation Processes Introduction: In the pharmaceutical industry, the wet granulation process is a critical method for producing tablets. It involves the agglomeration of powder particles using a liquid binder, which helps improve the flow and compaction properties of the powder mix. However, the…

Solid Dosage form, Tablets

Optimizing Layer Adhesion in Bilayer Tablet Compression

March 7, 2025 Admin

Optimizing Layer Adhesion in Bilayer Tablet Compression Optimizing Layer Adhesion in Bilayer Tablet Compression Introduction: Bilayer tablets are an innovative solution in the pharmaceutical industry, allowing for the combination of two active ingredients with distinct release profiles or chemical characteristics. This format is crucial in cases where combination therapy is necessary, providing patient convenience and…

Solid Dosage form, Tablets

Ensuring Uniform Blending of APIs in Powder Mixtures

March 6, 2025 Admin

Ensuring Uniform Blending of APIs in Powder Mixtures Ensuring Uniform Blending of APIs in Powder Mixtures Introduction: In pharmaceutical manufacturing, particularly in the production of solid dosage forms like tablets, the uniform blending of Active Pharmaceutical Ingredients (APIs) in powder mixtures is critical. This process ensures that each tablet contains the intended dosage and achieves…

Solid Dosage form, Tablets

Addressing API Migration in Bilayer Tablets During Long-Term Testing

March 6, 2025 Admin

Addressing API Migration in Bilayer Tablets During Long-Term Testing Addressing API Migration in Bilayer Tablets During Long-Term Testing Introduction: Bilayer tablets are an innovative pharmaceutical dosage form designed to deliver two different active pharmaceutical ingredients (APIs) or to control the release of a single API over time. However, the process of ensuring the stability and…

Solid Dosage form, Tablets

Resolving Weight Variation Failures in Bilayer Tablets

March 2, 2025 Admin

Resolving Weight Variation Failures in Bilayer Tablets Resolving Weight Variation Failures in Bilayer Tablets Introduction: In the pharmaceutical industry, bilayer tablets have emerged as a sophisticated solution for delivering multiple drugs or achieving different release profiles in a single dosage form. However, maintaining uniform weight across these tablets poses significant challenges, impacting quality and efficacy….

Solid Dosage form, Tablets