Tag: Formulation development

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing

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Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Introduction: In the pharmaceutical industry, enteric-coated tablets play a crucial role in ensuring that active pharmaceutical ingredients (APIs) are delivered to the intestine, bypassing the acidic environment of the stomach. This not only protects the drug from…

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Solid Dosage form, Tablets

Managing Excessive Binder Use in Wet Granulation Processes

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Managing Excessive Binder Use in Wet Granulation Processes Managing Excessive Binder Use in Wet Granulation Processes Introduction: In the pharmaceutical industry, wet granulation is a crucial process used to improve the flowability and compressibility of powder blends, ultimately ensuring the production of high-quality tablets. Binders play an essential role in wet granulation, providing the necessary…

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Solid Dosage form, Tablets

Managing Failures in Stress Testing for Controlled Release Tablets

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Managing Failures in Stress Testing for Controlled Release Tablets Managing Failures in Stress Testing for Controlled Release Tablets Introduction: In the pharmaceutical industry, controlled release tablets play a pivotal role in ensuring the precise delivery of active pharmaceutical ingredients (APIs) over an extended period. These tablets are designed to optimize therapeutic efficacy and improve patient…

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Solid Dosage form, Tablets

Addressing Coating Peel-Off During Stability Studies

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Addressing Coating Peel-Off During Stability Studies Addressing Coating Peel-Off During Stability Studies Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and integrity of tablet coatings is paramount. Coatings play a crucial role in protecting the active pharmaceutical ingredient (API), controlling release profiles, improving patient compliance, and enhancing the aesthetic appeal of the product….

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Solid Dosage form, Tablets

Poor reproducibility in monitoring capsule disintegration profiles.

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Poor reproducibility in monitoring capsule disintegration profiles. Poor reproducibility in monitoring capsule disintegration profiles. Introduction: The disintegration profile of capsules is a critical quality attribute that significantly impacts the bioavailability and therapeutic efficacy of the drug product. Ensuring consistent and reproducible disintegration times is essential for achieving regulatory compliance and maintaining product quality. Despite its…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

What are the advantages of using pre-formulated direct compression excipients?

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Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…

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Tablets

How are multi-layer tablets manufactured?

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Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…

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Tablets

What are the different tablet scoring techniques?

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Different Tablet Scoring Techniques Tablet scoring is a process used to create a groove or shallow indentation on a tablet’s surface. The scoring facilitates breaking the tablet into smaller parts, allowing patients to adjust the dose as needed. Tablet scoring is particularly useful for patients who have difficulty swallowing or need a lower dosage strength…

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Tablets

How are sustained-release tablets formulated?

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Formulation of Sustained-Release Tablets Sustained-release tablets, also known as extended-release tablets or controlled-release tablets, are designed to release the active pharmaceutical ingredient (API) over an extended period, maintaining a steady and controlled drug release profile. The formulation of sustained-release tablets requires careful selection of excipients and incorporation of drug release mechanisms to achieve the desired…

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Tablets

What is the purpose of using glidants in tablet manufacturing?

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Purpose of Using Glidants in Tablet Manufacturing Glidants, also known as lubricating glidants or flow aids, are additives used in tablet manufacturing to improve the flow properties of the tablet blend. They serve the crucial purpose of enhancing the flowability of powders or granules, making the tablet manufacturing process more efficient and consistent. Glidants play…

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Tablets

Explain the importance of using appropriate lubricants in tablet compression.

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Importance of Using Appropriate Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they help facilitate the tablet manufacturing process and ensure the production of high-quality tablets. Lubricants are added to tablet formulations to reduce friction between the tablet granules and the surfaces of the tablet punches and dies during compression….

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Tablets

How do you troubleshoot tablet sticking during compression?

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Troubleshooting Tablet Sticking During Compression Tablet sticking during compression can be a common problem in tablet manufacturing. It occurs when the tablet blend adheres to the punch faces, leading to difficulties in ejecting the tablets from the dies and affecting tablet quality. Troubleshooting tablet sticking involves identifying the root cause and implementing corrective actions. Here…

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Tablets