Tag: Formulation development

Troubleshooting Powder Segregation Issues During Validation of Compression Lines

May 25, 2025 Admin

Troubleshooting Powder Segregation Issues During Validation of Compression Lines Troubleshooting Powder Segregation Issues During Validation of Compression Lines Introduction: In the realm of pharmaceutical manufacturing, maintaining the uniformity and consistency of solid dosage forms, such as tablets, is crucial. One of the common challenges faced during the validation of compression lines is powder segregation. This…

Solid Dosage form, Tablets

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets

April 28, 2025 Admin

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Introduction: Coated tablets are a widely used solid dosage form in the pharmaceutical industry, offering benefits such as improved taste masking, controlled drug release, and enhanced stability. However, achieving consistent dissolution profiles is critical as it directly impacts the…

Solid Dosage form, Tablets

Poor validation of capsule weight variation for powders with low bulk density.

April 23, 2025 Admin

Poor validation of capsule weight variation for powders with low bulk density. Poor validation of capsule weight variation for powders with low bulk density. Introduction: In the pharmaceutical industry, the formulation and manufacture of capsules are crucial for ensuring patient safety and therapeutic efficacy. Capsules, particularly solid oral dosage forms, remain a popular choice due…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in capsule drying validation results for multi-layer formulations.

April 19, 2025 Admin

Poor reproducibility in capsule drying validation results for multi-layer formulations. Poor reproducibility in capsule drying validation results for multi-layer formulations. Introduction: The pharmaceutical industry continuously strives to enhance the quality and efficacy of solid oral dosage forms, including capsules. Among these, multi-layer formulations have gained popularity due to their ability to deliver complex dosing regimens…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in rinse sampling data for lipid-based formulations.

April 17, 2025 Admin

Poor reproducibility in rinse sampling data for lipid-based formulations. Poor reproducibility in rinse sampling data for lipid-based formulations. Introduction: Lipid-based formulations have gained significant attention in the pharmaceutical industry due to their ability to enhance the bioavailability of poorly water-soluble drugs. However, ensuring the cleanliness of manufacturing equipment used for these formulations poses unique challenges,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in testing soft gelatin capsules with high oil content.

April 16, 2025 Admin

Challenges in testing soft gelatin capsules with high oil content. Challenges in testing soft gelatin capsules with high oil content Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry, offering unique advantages such as improved bioavailability and patient compliance. However, when these capsules contain high oil content, they present significant challenges…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in monitoring powder flow properties during encapsulation.

April 7, 2025 Admin

Poor reproducibility in monitoring powder flow properties during encapsulation. Poor reproducibility in monitoring powder flow properties during encapsulation. Introduction: In the pharmaceutical industry, encapsulation is a critical process for the manufacturing of solid oral dosage forms. The flow properties of powders are essential, as they determine the efficiency and consistency of the encapsulation process. Poor…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of analytical methods for multi-drug capsule formulations.

April 3, 2025 Admin

Poor validation of analytical methods for multi-drug capsule formulations. Poor validation of analytical methods for multi-drug capsule formulations. Introduction: In the pharmaceutical industry, the development of multi-drug capsule formulations is a sophisticated process that requires precision and accuracy. The validation of analytical methods for these formulations is crucial as it ensures the quality, efficacy, and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent capsule appearance during accelerated validation studies.

April 1, 2025 Admin

Problems with ensuring consistent capsule appearance during accelerated validation studies. Problems with ensuring consistent capsule appearance during accelerated validation studies. Introduction: In the pharmaceutical industry, ensuring the consistent appearance of capsules is crucial for maintaining product quality and consumer trust. During accelerated validation studies, which are designed to predict the long-term stability of a product…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Poor Adhesion in Film Coatings During Stability Studies

March 29, 2025 Admin

Addressing Poor Adhesion in Film Coatings During Stability Studies Addressing Poor Adhesion in Film Coatings During Stability Studies Introduction: In the realm of pharmaceutical manufacturing, film coatings on tablets are crucial for various reasons, including enhancing tablet stability, controlling drug release, masking unpleasant tastes, and improving aesthetic appeal. However, one of the common challenges faced…

Solid Dosage form, Tablets

Identifying Causes of Poor Disintegration in Controlled Release Tablets

March 27, 2025 Admin

Identifying Causes of Poor Disintegration in Controlled Release Tablets Identifying Causes of Poor Disintegration in Controlled Release Tablets Introduction: In the realm of pharmaceuticals, controlled release tablets have become a cornerstone of modern drug delivery systems. These formulations are designed to release the active pharmaceutical ingredient (API) at a predetermined rate, providing therapeutic benefits over…

Solid Dosage form, Tablets

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing

March 22, 2025 Admin

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Introduction: In the pharmaceutical industry, enteric-coated tablets play a crucial role in ensuring that active pharmaceutical ingredients (APIs) are delivered to the intestine, bypassing the acidic environment of the stomach. This not only protects the drug from…

Solid Dosage form, Tablets