Tag: Formulation Challenges

Poor reproducibility in stability data across multiple batches.

March 8, 2025 Admin

Poor reproducibility in stability data across multiple batches. Poor Reproducibility in Stability Data Across Multiple Batches Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability of products is paramount. Stability data are crucial for determining the shelf life and storage conditions of pharmaceutical products, ensuring they remain safe and effective for patients throughout their…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule filling for lipid-based formulations.

March 8, 2025 Admin

Difficulty in validating capsule filling for lipid-based formulations. Difficulty in Validating Capsule Filling for Lipid-Based Formulations Introduction: Lipid-based formulations have gained significant attention in the pharmaceutical industry due to their potential to improve the bioavailability of poorly soluble drugs. As a result, encapsulating these formulations, particularly in hard or soft gelatin capsules, has become increasingly…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in testing for capsule tamper resistance.

March 7, 2025 Admin

Difficulty in testing for capsule tamper resistance. Difficulty in Testing for Capsule Tamper Resistance Introduction: In the pharmaceutical industry, ensuring the integrity and safety of drug products is paramount. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and efficiency in delivering medication. However, they are vulnerable to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Preventing Powder Sticking in Die Cavities During Compression

March 7, 2025 Admin

Preventing Powder Sticking in Die Cavities During Compression Preventing Powder Sticking in Die Cavities During Compression Introduction: In the realm of pharmaceutical manufacturing, tablet compression is a critical step that transforms powder blends into solid dosage forms. However, one common challenge faced during this process is the sticking of powder to the die cavities. This…

Solid Dosage form, Tablets

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets

March 7, 2025 Admin

Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Addressing Non-Homogeneity in Powder Blends for Multi-API Tablets Introduction: In the pharmaceutical industry, the production of multi-API (Active Pharmaceutical Ingredient) tablets requires precise formulation and meticulous blending to ensure each tablet meets stringent quality standards. Achieving homogeneity in powder blends is crucial for ensuring that every tablet…

Solid Dosage form, Tablets

Troubleshooting Brittleness in Multi-Layer Tablets During Hardness Testing

March 5, 2025 Admin

Troubleshooting Brittleness in Multi-Layer Tablets During Hardness Testing Troubleshooting Brittleness in Multi-Layer Tablets During Hardness Testing Introduction: In the world of pharmaceutical manufacturing, the production of multi-layer tablets is both an art and a science. These tablets are designed to deliver multiple active ingredients, each at different release rates, making them highly effective for patients…

Solid Dosage form, Tablets

Resolving Non-Uniform API Distribution in Extended Release Tablets Over Time

March 5, 2025 Admin

Resolving Non-Uniform API Distribution in Extended Release Tablets Over Time Resolving Non-Uniform API Distribution in Extended Release Tablets Over Time Introduction: The pharmaceutical industry is constantly evolving, with a significant focus on developing efficient drug delivery systems. Extended release tablets are a crucial component of this landscape, designed to release active pharmaceutical ingredients (APIs) over…

Solid Dosage form, Tablets

Poor reproducibility in capsule sealing tests for blister packs.

March 4, 2025 Admin

Poor reproducibility in capsule sealing tests for blister packs. Poor reproducibility in capsule sealing tests for blister packs. Introduction: The pharmaceutical industry heavily relies on blister packaging to protect and deliver solid oral dosage forms like capsules. Ensuring the integrity of capsule seals in blister packs is crucial for maintaining the product’s efficacy, stability, and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate validation protocols for new capsule formulations.

March 4, 2025 Admin

Inadequate validation protocols for new capsule formulations. Inadequate Validation Protocols for New Capsule Formulations Introduction: The pharmaceutical industry is continually evolving, with innovations leading to new and effective drug delivery systems. Among these, capsules remain a popular choice due to their ease of administration and ability to encapsulate a wide range of drug compounds. However,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Non-Uniform Coating Thickness in Sugar-Coated Tablets

March 3, 2025 Admin

Addressing Non-Uniform Coating Thickness in Sugar-Coated Tablets Addressing Non-Uniform Coating Thickness in Sugar-Coated Tablets Introduction: Sugar-coated tablets are a time-tested pharmaceutical dosage form, favored for their aesthetic appeal, masking of unpleasant tastes, and protection of the core tablet. Achieving a uniformly coated product is critical not only for consumer acceptance but also for ensuring consistent…

Solid Dosage form, Tablets

Addressing Challenges in API Loading During Granulation

March 2, 2025 Admin

Addressing Challenges in API Loading During Granulation Addressing Challenges in API Loading During Granulation Introduction: In the pharmaceutical industry, granulation is a critical process in the production of solid dosage forms such as tablets. Ensuring uniform distribution of the Active Pharmaceutical Ingredient (API) is vital for achieving the desired therapeutic effects and ensuring patient safety….

Solid Dosage form, Tablets

Addressing Coating Delamination Issues During In-Process Quality Checks

March 2, 2025 Admin

Addressing Coating Delamination Issues During In-Process Quality Checks Addressing Coating Delamination Issues During In-Process Quality Checks Introduction: In the pharmaceutical industry, tablets are one of the most common solid dosage forms. The coating of these tablets plays a pivotal role not only in aesthetics but also in functionality, including protection from environmental conditions, masking taste,…

Solid Dosage form, Tablets