Tag: Formulation Challenges

Poor validation of capsule transparency for certain formulations.

March 25, 2025 Admin

Poor validation of capsule transparency for certain formulations. Poor validation of capsule transparency for certain formulations. Introduction: In the pharmaceutical industry, the transparency of capsules, especially gelatin-based ones, plays a critical role in both consumer perception and regulatory compliance. The visual clarity of capsules can affect patient trust, as transparency often signifies purity and lack…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring complete removal of oils and fats from soft gelatin equipment.

March 24, 2025 Admin

Problems with ensuring complete removal of oils and fats from soft gelatin equipment. Problems with ensuring complete removal of oils and fats from soft gelatin equipment. Introduction: In the pharmaceutical industry, soft gelatin capsules are a popular dosage form due to their patient-friendly administration and ability to encapsulate a wide range of substances. However, the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Preventing Non-Uniform Thickness in Enteric-Coated Tablet Layers

March 24, 2025 Admin

Preventing Non-Uniform Thickness in Enteric-Coated Tablet Layers Preventing Non-Uniform Thickness in Enteric-Coated Tablet Layers Introduction: In the pharmaceutical industry, enteric-coated tablets are designed to withstand the acidic environment of the stomach and dissolve in the more neutral or alkaline environment of the intestine. This functionality is crucial for protecting active pharmaceutical ingredients (APIs) that are…

Solid Dosage form, Tablets

Investigating Failures in Dissolution Testing for Sustained Release Tablets

March 22, 2025 Admin

Investigating Failures in Dissolution Testing for Sustained Release Tablets Investigating Failures in Dissolution Testing for Sustained Release Tablets Introduction: The pharmaceutical industry is a cornerstone of modern medicine, with sustained release tablets playing a crucial role in controlled drug delivery systems. These formulations are designed to release the active pharmaceutical ingredient (API) at a predetermined…

Solid Dosage form, Tablets

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets

March 22, 2025 Admin

Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Troubleshooting Failures in In-Process Monitoring for Film-Coated Tablets Introduction: In the pharmaceutical industry, film-coated tablets represent a significant portion of solid dosage forms due to their enhanced stability, ease of swallowing, and aesthetic attributes. The coating process is critical, as it affects the tablet’s performance and patient…

Solid Dosage form, Tablets

Addressing Over-Lubrication in Powder Mixtures for Blending

March 21, 2025 Admin

Addressing Over-Lubrication in Powder Mixtures for Blending Addressing Over-Lubrication in Powder Mixtures for Blending Introduction: In the pharmaceutical industry, the formulation of solid dosage forms like tablets is a finely tuned process that requires precision and careful consideration of multiple variables. Among these, the use of lubricants in powder mixtures for blending is crucial to…

Solid Dosage form, Tablets

Identifying Root Causes of Poor Disintegration in Film-Coated Tablets

March 21, 2025 Admin

Identifying Root Causes of Poor Disintegration in Film-Coated Tablets Identifying Root Causes of Poor Disintegration in Film-Coated Tablets Introduction: Film-coated tablets are a popular solid dosage form in the pharmaceutical industry due to their enhanced stability, ease of ingestion, and ability to mask unpleasant tastes. However, one critical quality attribute for these tablets is their…

Solid Dosage form, Tablets

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets

March 21, 2025 Admin

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Introduction: Enteric tablets are specially designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This targeted dissolution is critical for drugs that are sensitive to stomach acid…

Solid Dosage form, Tablets

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets

March 20, 2025 Admin

Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Addressing Non-Compliance in Stability Studies for Film-Coated Tablets Introduction: In the pharmaceutical industry, stability studies play a crucial role in ensuring the efficacy, safety, and quality of drug products. For film-coated tablets, stability studies are essential to evaluate how the product maintains its intended physical, chemical, microbiological,…

Solid Dosage form, Tablets

Difficulty in validating capsule filling processes for multi-dose formulations.

March 18, 2025 Admin

Difficulty in validating capsule filling processes for multi-dose formulations. Difficulty in validating capsule filling processes for multi-dose formulations. Introduction: In the pharmaceutical industry, capsule filling processes for multi-dose formulations present unique challenges that require careful validation to ensure product quality and patient safety. As capsules remain a popular dosage form due to their convenience, stability,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Fines Generation During Compression of Immediate Release Tablets

March 17, 2025 Admin

Managing Fines Generation During Compression of Immediate Release Tablets Managing Fines Generation During Compression of Immediate Release Tablets Introduction: In the pharmaceutical industry, the production of immediate-release tablets is a crucial process that requires meticulous attention to detail. One of the significant challenges faced during the tablet manufacturing process is the generation of fines. Fines…

Solid Dosage form, Tablets

Identifying Causes of Tablet Swelling During Disintegration Testing

March 17, 2025 Admin

Identifying Causes of Tablet Swelling During Disintegration Testing Identifying Causes of Tablet Swelling During Disintegration Testing Introduction: In the pharmaceutical industry, ensuring the quality and efficacy of solid dosage forms, such as tablets, is paramount. A critical aspect of this quality control is disintegration testing, a process that evaluates how quickly a tablet breaks down…

Solid Dosage form, Tablets