Tag: Effervescent tablet formulation​

Troubleshooting Spray Coating Failures in Sugar-Coated Tablets Techniques for Troubleshooting Spray Coating Failures in Sugar-Coated Tablets Overview: Spray coating is a critical step in the sugar-coating process, widely used in the pharmaceutical industry to provide tablets with an additional protective layer. This process not only enhances the tablet’s appearance but also ensures stability, ease of…

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Controlling Static Buildup in Blending Equipment for Large-Scale Batches Techniques for Controlling Static Buildup in Blending Equipment for Large-Scale Batches Overview: Static buildup in blending equipment is a common challenge in the pharmaceutical industry, especially during the manufacturing of large-scale batches. The process of mixing powders in blending equipment can lead to the accumulation of…

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Preventing Layer Separation in Complex Multi-Layer Tablet Designs Techniques for Preventing Layer Separation in Complex Multi-Layer Tablet Designs Overview: Multi-layer tablets are designed to deliver multiple active pharmaceutical ingredients (APIs) or to control the release profile of a single API over time. These tablets typically consist of several distinct layers, each containing different formulations or…

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Managing Over-Drying of Hygroscopic Tablets in Fluid Bed Dryers Techniques for Managing Over-Drying of Hygroscopic Tablets in Fluid Bed Dryers Overview: Hygroscopic tablets, which tend to absorb moisture from the environment, present a unique set of challenges during the drying process, particularly when using fluid bed dryers. Fluid bed drying is a commonly used technique…

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Avoiding Tablet Shape Deformation During High-Speed Compression Techniques for Avoiding Tablet Shape Deformation During High-Speed Compression Overview: High-speed compression is a crucial step in tablet manufacturing that allows for efficient production of large batches. However, during this process, tablets may experience shape deformation due to excessive force or improper compaction settings. Tablet shape deformation can…

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Addressing Inconsistent Coating Thickness in Enteric-Coated Tablets Techniques for Addressing Inconsistent Coating Thickness in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from the acidic environment of the stomach, allowing for the release of the API in the more neutral environment of the intestines. This coating is essential for…

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Real-Time Process Adjustments During Continuous Manufacturing Techniques for Real-Time Process Adjustments During Continuous Manufacturing Overview: Continuous manufacturing (CM) has emerged as a game-changing approach in pharmaceutical production, offering numerous benefits over traditional batch manufacturing. CM allows for the continuous production of pharmaceutical products, providing higher efficiency, reduced production costs, and better scalability. However, to achieve…

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Optimizing Spray Gun Calibration for Film Coating Processes Techniques for Optimizing Spray Gun Calibration for Film Coating Processes Overview: In pharmaceutical manufacturing, film coating is used to apply a thin, uniform layer of coating to tablets, providing benefits such as taste masking, protection of the API, and controlled release properties. One of the key components…

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Troubleshooting Adhesion Problems in Tablets with High API Loads Techniques for Troubleshooting Adhesion Problems in Tablets with High API Loads Overview: Tablets with high active pharmaceutical ingredient (API) loads present unique challenges during the manufacturing process, particularly when it comes to adhesion problems. Adhesion refers to the ability of a tablet’s components, such as the…

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Managing Over-Drying in Sugar-Coated Tablets During Finishing Techniques for Managing Over-Drying in Sugar-Coated Tablets During Finishing Overview: In the pharmaceutical industry, sugar-coating is commonly used to improve the appearance, stability, and taste of tablets. The finishing stage of the sugar-coating process involves the application of a final layer of coating solution, followed by drying to…

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Addressing Segregation in Roller Compaction for Controlled Release Tablets Techniques for Addressing Segregation in Roller Compaction for Controlled Release Tablets Overview: Roller compaction is a widely used dry granulation technique in tablet manufacturing, particularly for producing controlled release tablets. This process involves compressing powder blends between two rotating rollers to form sheets, which are subsequently…

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Preventing Coating Layer Damage During Tablet Packaging Techniques for Preventing Coating Layer Damage During Tablet Packaging Overview: The tablet coating process is essential for ensuring the stability, aesthetic appeal, and controlled release of pharmaceutical products. However, during the tablet packaging phase, coated tablets are often subjected to mechanical stresses that can result in coating layer…

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