Tag: Drying Process

Managing Residual Moisture Issues in Dryers During Cleaning Validation Studies

June 5, 2025 Admin

Managing Residual Moisture Issues in Dryers During Cleaning Validation Studies Managing Residual Moisture Issues in Dryers During Cleaning Validation Studies Introduction: In the pharmaceutical industry, ensuring the cleanliness and safety of manufacturing equipment is crucial to maintaining product integrity and patient safety. Residual moisture in dryers, used in the production of solid dosage forms like…

Solid Dosage form, Tablets

High rejection rates due to shell deformation during drying.

April 12, 2025 Admin

High rejection rates due to shell deformation during drying. High rejection rates due to shell deformation during drying. Introduction: Within the realm of pharmaceutical manufacturing, solid oral dosage forms such as capsules remain a staple due to their convenience and efficacy in drug delivery. However, one of the recurring challenges in the production of both…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating capsule drying equipment for dual-layer formulations.

April 6, 2025 Admin

Challenges in validating capsule drying equipment for dual-layer formulations. Challenges in validating capsule drying equipment for dual-layer formulations. Introduction: In the realm of pharmaceutical manufacturing, the development and validation of dual-layer formulations present unique challenges, particularly in the drying stage of capsule production. The drying process is critical to ensuring the stability, efficacy, and safety…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Detecting Agglomeration in Fluid Bed Granules During Drying

March 20, 2025 Admin

Detecting Agglomeration in Fluid Bed Granules During Drying Detecting Agglomeration in Fluid Bed Granules During Drying Introduction: Fluid bed granulation is a pivotal process in the pharmaceutical industry, integral to the production of tablets. It involves the transformation of fine powders into larger, free-flowing granules by fluidizing them in a bed and binding with a…

Solid Dosage form, Tablets

Troubleshooting Cracking in Enteric-Coated Tablets During Drying

March 19, 2025 Admin

Troubleshooting Cracking in Enteric-Coated Tablets During Drying Troubleshooting Cracking in Enteric-Coated Tablets During Drying Introduction: Enteric-coated tablets are a vital component of modern pharmaceuticals, designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestine. This targeted delivery is crucial for the efficacy and safety of certain…

Solid Dosage form, Tablets

Preventing Granule Breakage During Fluid Bed Drying

March 14, 2025 Admin

Preventing Granule Breakage During Fluid Bed Drying Preventing Granule Breakage During Fluid Bed Drying Introduction: In the pharmaceutical industry, fluid bed drying is a critical process in the production of solid dosage forms, particularly tablets. This method is favored for its efficiency in drying granules, which are the intermediate product before compression into tablets. However,…

Solid Dosage form, Tablets

Problems with validating capsule drying equipment for gelatin-free capsules.

March 4, 2025 Admin

Problems with validating capsule drying equipment for gelatin-free capsules. Problems with Validating Capsule Drying Equipment for Gelatin-Free Capsules Introduction: In the ever-evolving world of pharmaceuticals, the demand for gelatin-free capsules has increased significantly. These alternatives, often made from materials like hydroxypropyl methylcellulose (HPMC), offer benefits such as vegetarian suitability and improved stability. However, with innovation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms