Tag: drying optimization

High rejection rates due to shell deformation during drying.

April 12, 2025 Admin

High rejection rates due to shell deformation during drying. High rejection rates due to shell deformation during drying. Introduction: Within the realm of pharmaceutical manufacturing, solid oral dosage forms such as capsules remain a staple due to their convenience and efficacy in drug delivery. However, one of the recurring challenges in the production of both…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for validating capsule drying profiles for soft gelatin capsules.

April 10, 2025 Admin

Inadequate systems for validating capsule drying profiles for soft gelatin capsules. Inadequate systems for validating capsule drying profiles for soft gelatin capsules. Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry due to their versatility in encapsulating a wide range of substances, including liquids, suspensions, and semi-solids. Ensuring the proper drying…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in validating capsule drying equipment for dual-layer formulations.

April 6, 2025 Admin

Challenges in validating capsule drying equipment for dual-layer formulations. Challenges in validating capsule drying equipment for dual-layer formulations. Introduction: In the realm of pharmaceutical manufacturing, the development and validation of dual-layer formulations present unique challenges, particularly in the drying stage of capsule production. The drying process is critical to ensuring the stability, efficacy, and safety…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Heat Damage in API Granules During Drying Validation

April 3, 2025 Admin

Troubleshooting Heat Damage in API Granules During Drying Validation Troubleshooting Heat Damage in API Granules During Drying Validation Introduction: In the pharmaceutical industry, the drying process of Active Pharmaceutical Ingredient (API) granules is a critical step in the production of solid dosage forms such as tablets. Ensuring the stability and integrity of APIs during drying…

Solid Dosage form, Tablets

Difficulty in validating capsule drying processes for dual-layer capsules.

April 2, 2025 Admin

Difficulty in validating capsule drying processes for dual-layer capsules. Difficulty in validating capsule drying processes for dual-layer capsules Introduction: The pharmaceutical industry is constantly evolving, with innovations aimed at improving drug delivery systems and enhancing patient compliance. One such innovation is the development of dual-layer capsules. These capsules offer the advantage of delivering multiple drugs…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Detecting Agglomeration in Fluid Bed Granules During Drying

March 20, 2025 Admin

Detecting Agglomeration in Fluid Bed Granules During Drying Detecting Agglomeration in Fluid Bed Granules During Drying Introduction: Fluid bed granulation is a pivotal process in the pharmaceutical industry, integral to the production of tablets. It involves the transformation of fine powders into larger, free-flowing granules by fluidizing them in a bed and binding with a…

Solid Dosage form, Tablets

Troubleshooting Cracking in Enteric-Coated Tablets During Drying

March 19, 2025 Admin

Troubleshooting Cracking in Enteric-Coated Tablets During Drying Troubleshooting Cracking in Enteric-Coated Tablets During Drying Introduction: Enteric-coated tablets are a vital component of modern pharmaceuticals, designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestine. This targeted delivery is crucial for the efficacy and safety of certain…

Solid Dosage form, Tablets

Preventing Cracking in Enteric-Coated Tablet Layers During Drying

March 12, 2025 Admin

Preventing Cracking in Enteric-Coated Tablet Layers During Drying Preventing Cracking in Enteric-Coated Tablet Layers During Drying Introduction: The pharmaceutical industry continuously strives to improve the quality and efficacy of its products. Among the myriad of dosage forms, enteric-coated tablets play a crucial role in ensuring drug stability and targeted release. However, maintaining the integrity of…

Solid Dosage form, Tablets

Problems with validating capsule drying equipment for gelatin-free capsules.

March 4, 2025 Admin

Problems with validating capsule drying equipment for gelatin-free capsules. Problems with Validating Capsule Drying Equipment for Gelatin-Free Capsules Introduction: In the ever-evolving world of pharmaceuticals, the demand for gelatin-free capsules has increased significantly. These alternatives, often made from materials like hydroxypropyl methylcellulose (HPMC), offer benefits such as vegetarian suitability and improved stability. However, with innovation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High rejection rates due to uneven capsule drying.

March 2, 2025 Admin

High rejection rates due to uneven capsule drying. High Rejection Rates Due to Uneven Capsule Drying Introduction: The pharmaceutical industry constantly strives to enhance the quality and efficiency of its manufacturing processes. Among the myriad of challenges faced, the production of capsules, both hard and soft gelatin, stands out due to its complexity. One significant…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms