Tag: Dry granulation

Significance of Disintegration Time in Tablet Formulation In the field of pharmaceutical manufacturing, the disintegration time of tablets is a critical parameter that directly influences the drug’s efficacy, bioavailability, and patient compliance. Disintegration time refers to the period it takes for a tablet to break down into smaller particles and disperse in a solution, typically…

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Controlling Tablet Porosity During Production Tablet porosity refers to the amount of empty space or voids within a tablet. Controlling tablet porosity is essential in tablet manufacturing to ensure consistent drug content, disintegration, and dissolution properties. The porosity of tablets can be influenced by several factors during the production process. Here are some key methods…

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Different Types of Tablet Disintegration Tests Tablet disintegration tests are crucial quality control tests used to assess the time it takes for a tablet to break down into small particles in a standardized disintegration medium. Disintegration testing is essential to ensure that the tablet disintegrates rapidly and completely after ingestion, allowing for proper drug release…

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Importance of Bulk Density in Tablet Manufacturing Bulk density is a crucial parameter in tablet manufacturing that refers to the mass of a powder divided by its bulk volume. It plays a significant role in the formulation and production of high-quality tablets. Here’s why bulk density is important in tablet manufacturing: 1. Formulation Development Bulk…

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Formulation and Compression of Bi-Layer Tablets Bi-layer tablets are a type of pharmaceutical tablet that consists of two distinct layers with different drug formulations. Each layer serves a specific purpose, and the two layers are compressed together to form a single tablet. Here’s how bi-layer tablets are formulated and compressed: Formulation of Bi-Layer Tablets Layer…

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Advantages of Wet Granulation Wet granulation is a widely used pharmaceutical manufacturing process that involves the addition of liquid binders to powder mixtures to create granules. This process offers several advantages over other granulation techniques, such as dry granulation. 1. Improved Granule Characteristics Wet granulation facilitates the creation of granules with uniform size, shape, and…

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Advantages of Dry Granulation Dry granulation is a pharmaceutical manufacturing process used to convert powdered ingredients into granules without the use of any liquid binders. This process offers several advantages over other granulation techniques, such as wet granulation. 1. Preservation of Thermally Sensitive Ingredients Dry granulation is particularly advantageous when dealing with thermally sensitive ingredients….

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Tablet Capping: Causes and Prevention Tablet capping is a tablet defect that occurs during the compression process when the upper or lower part of the tablet separates horizontally from the main body, resembling a cap. It can lead to tablets with compromised integrity, reduced drug content, and poor visual appearance. Understanding the causes of tablet…

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Types of Tablet Presses Used in Manufacturing Tablet presses are essential machines used in pharmaceutical manufacturing to compress powder blends into solid tablets of various shapes and sizes. There are several types of tablet presses available, each offering specific advantages and capabilities. Here are the different types of tablet presses commonly used in tablet manufacturing:…

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Manufacturing Orally Disintegrating Tablets (ODTs) Orally disintegrating tablets (ODTs), also known as fast-dissolving or quick-dissolving tablets, are a popular dosage form designed to rapidly disintegrate and dissolve in the mouth without the need for water. ODTs offer advantages in patient convenience and compliance, especially for individuals who have difficulty swallowing traditional tablets or capsules. The…

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Factors Affecting Tablet Dissolution Rate The dissolution rate of a tablet refers to how quickly the tablet disintegrates and releases the active pharmaceutical ingredient (API) into the surrounding medium, typically water, in a laboratory test. The dissolution rate is a critical parameter as it directly impacts the drug’s bioavailability and effectiveness. Several factors can influence…

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Tablet Weight Variation and Acceptable Limits Tablet weight variation is a critical quality parameter in tablet manufacturing that measures the consistency of tablet weight among a batch of tablets. It ensures that each tablet contains the correct amount of active pharmaceutical ingredient (API) and excipients, and that the tablets deliver the intended dose to patients….

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