Tag: Dry granulation in tablet production​

Optimizing Spray Gun Settings for Uniform Coating Thickness Effective Strategies for Optimizing Spray Gun Settings for Uniform Coating Thickness Overview: Spray coating is a critical step in the pharmaceutical manufacturing process, particularly when applying coatings to tablets. Achieving a uniform coating thickness is essential to ensure consistent drug release, tablet integrity, and product aesthetics. However,…

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Addressing Core Erosion During Sugar Coating Effective Strategies for Addressing Core Erosion During Sugar Coating Overview: Sugar coating is a widely used technique in pharmaceutical manufacturing to coat tablets, providing them with a sweet taste, a smooth finish, and protection against environmental factors. However, one of the challenges faced during the sugar-coating process is core…

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Impact of Particle Size on Tablet Compaction and Compression Understanding the Impact of Particle Size on Tablet Compaction and Compression Overview: Tablet compaction and compression are critical steps in pharmaceutical manufacturing that directly influence tablet quality, including hardness, dissolution, and bioavailability. The size and distribution of the particles in the powder blend used for tablet…

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Troubleshooting Granule Segregation in Fluidized Beds Effective Strategies for Troubleshooting Granule Segregation in Fluidized Beds Overview: Granule segregation is a common issue in the pharmaceutical manufacturing process, particularly during the drying and granulation stages. This problem becomes even more pronounced in fluidized bed systems, where powders or granules are suspended and dried through the flow…

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Managing Cross-Contamination Risks in Shared Manufacturing Facilities Effective Strategies for Managing Cross-Contamination Risks in Shared Manufacturing Facilities Overview: In pharmaceutical manufacturing, cross-contamination poses a significant risk, especially in facilities where multiple products are manufactured in the same space. The unintended transfer of substances from one product batch to another can lead to serious consequences such…

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Role of Anti-Tacking Agents in High-Speed Coating Machines Effective Role of Anti-Tacking Agents in High-Speed Coating Machines Overview: High-speed coating machines are widely used in pharmaceutical manufacturing to apply coatings to tablets for various purposes such as taste masking, controlled release, and enteric protection. However, during the coating process, a significant issue that arises is…

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Troubleshooting Adhesion Failure in Enteric-Coated Tablets Effective Strategies for Troubleshooting Adhesion Failure in Enteric-Coated Tablets Overview: Enteric-coated tablets are designed to protect the active pharmaceutical ingredient (API) from degradation in the stomach and to ensure that the drug is released in the intestines. However, one common issue in the production of enteric-coated tablets is adhesion…

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Reducing Electrostatic Charge in Powder Blending Effective Solutions for Reducing Electrostatic Charge in Powder Blending Overview: Electrostatic charge accumulation in powder blends is a significant challenge in pharmaceutical manufacturing, especially during processes like powder blending. This charge can lead to powder clumping, inconsistent flow, and poor blend uniformity, which ultimately affects tablet formation and product…

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Preventing Overloading in Tablet Press Hoppers Effective Strategies for Preventing Overloading in Tablet Press Hoppers Overview: Overloading in tablet press hoppers is a common issue in tablet manufacturing that can lead to a variety of operational problems, such as inconsistent tablet weight, reduced tablet quality, and increased wear and tear on equipment. The hopper is…

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Addressing Over-Lubrication Issues in Tablet Manufacturing Effective Solutions for Addressing Over-Lubrication Issues in Tablet Manufacturing Overview: Lubrication plays a critical role in tablet manufacturing by reducing friction between the tablet material and the compression equipment, facilitating smooth tablet ejection, and preventing sticking during the compression process. However, excessive lubrication, known as over-lubrication, can lead to…

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Managing Spray Uniformity in Film Coating Machines Effective Approaches for Managing Spray Uniformity in Film Coating Machines Overview: Film coating is a critical step in pharmaceutical tablet manufacturing that applies a thin, uniform coating to the tablet’s surface to protect the active pharmaceutical ingredient (API), mask the taste, and control drug release. However, achieving uniform…

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Preventing Tablet Chipping During Compression Effective Strategies for Preventing Tablet Chipping During Compression Overview: Tablet chipping is a common issue encountered during tablet compression, where fragments of the tablet break off at the edges, resulting in defects and compromised product quality. This problem not only affects the appearance of the tablets but can also lead…

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