Tag: Drug stability

Poor reproducibility in dissolution testing results for capsules stored under stressed conditions.

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Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Poor reproducibility in dissolution testing results for capsules stored under stressed conditions. Introduction: Dissolution testing is a critical quality control procedure in the pharmaceutical industry, especially for solid oral dosage forms such as capsules. It ensures that the drug releases at the intended…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures

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Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Introduction: In the pharmaceutical industry, the stability of Active Pharmaceutical Ingredients (APIs) is crucial for ensuring the efficacy and safety of medications. Film-coated tablets are a popular dosage form, offering benefits such as ease of…

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Solid Dosage form, Tablets

Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing

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Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Investigating Non-Uniform Dissolution in Enteric-Coated Tablets During Testing Introduction: The pharmaceutical industry constantly strives to develop effective drug delivery mechanisms, with enteric-coated tablets serving as a crucial form of solid dosage. These tablets are designed to resist the acidic environment of the stomach, releasing their active ingredients…

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Solid Dosage form, Tablets

Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage

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Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage Troubleshooting Surface Roughness in Sugar-Coated Tablets During Storage Introduction: Sugar-coated tablets are a prevalent form of oral pharmaceutical dosage due to their aesthetic appeal, taste masking abilities, and protective properties. However, during storage, these tablets can sometimes develop surface roughness, which can compromise their appearance, consumer acceptance,…

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Solid Dosage form, Tablets

Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets

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Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Managing Non-Homogeneity in Dissolution Profiles for Coated Tablets Introduction: Coated tablets are a widely used solid dosage form in the pharmaceutical industry, offering benefits such as improved taste masking, controlled drug release, and enhanced stability. However, achieving consistent dissolution profiles is critical as it directly impacts the…

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Solid Dosage form, Tablets

Addressing Seal Integrity Failures in Sachet Packaging for Immediate Release Tablets

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Addressing Seal Integrity Failures in Sachet Packaging for Immediate Release Tablets Addressing Seal Integrity Failures in Sachet Packaging for Immediate Release Tablets Introduction: In the pharmaceutical industry, the packaging of immediate release tablets is crucial for ensuring their efficacy and shelf life. Sachet packaging, a popular choice for its convenience and cost-effectiveness, must maintain seal…

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Solid Dosage form, Tablets

Addressing Deviations in Stability Studies for Bilayer Tablets

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Addressing Deviations in Stability Studies for Bilayer Tablets Addressing Deviations in Stability Studies for Bilayer Tablets Introduction: Bilayer tablets have emerged as a versatile drug delivery system, offering the advantage of combining two different drugs or formulations with varied release profiles in a single dosage form. This innovation not only improves patient compliance but also…

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Solid Dosage form, Tablets

Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions

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Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions Introduction: Sugar-coated tablets have long been a staple in pharmaceutical formulations, offering benefits such as masking unpleasant tastes, improving tablet appearance, and protecting active pharmaceutical ingredients (APIs) from environmental factors. However, they also present unique challenges, particularly…

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Solid Dosage form, Tablets

Investigating Impact of Oxidative Stress on Coated Tablet Stability

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Investigating Impact of Oxidative Stress on Coated Tablet Stability Investigating Impact of Oxidative Stress on Coated Tablet Stability Introduction: In the pharmaceutical industry, the stability of coated tablets is a critical factor in ensuring drug efficacy and safety over their shelf life. Coated tablets are designed to protect the active pharmaceutical ingredients (APIs) from environmental…

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Solid Dosage form, Tablets

Poor correlation between in vitro dissolution and stability data.

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Poor correlation between in vitro dissolution and stability data. Poor correlation between in vitro dissolution and stability data. Introduction: In the pharmaceutical industry, the correlation between in vitro dissolution and stability data is pivotal for ensuring the efficacy and safety of solid oral dosage forms, particularly capsules. Dissolution testing is a key quality control measure…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in validating capsule integrity for long-term storage conditions.

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Difficulty in validating capsule integrity for long-term storage conditions. Difficulty in validating capsule integrity for long-term storage conditions. Introduction: In the pharmaceutical industry, ensuring the integrity of capsules over their shelf life is paramount. Capsules, whether hard or soft gelatin, are a preferred dosage form due to their ease of administration and ability to encapsulate…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor correlation between laboratory and field stability data for capsules.

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Poor correlation between laboratory and field stability data for capsules. Poor correlation between laboratory and field stability data for capsules. Introduction: In the pharmaceutical industry, stability testing is a critical component that ensures the safety, efficacy, and quality of drug products throughout their shelf life. Capsules, both hard and soft gelatin, are popular solid oral…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms