Tag: Drug stability testing

Root Cause Analysis for Failures in Dissolution Testing for Enteric Tablets

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Root Cause Analysis for Failures in Dissolution Testing for Enteric Tablets Root Cause Analysis for Failures in Dissolution Testing for Enteric Tablets Introduction: The pharmaceutical industry is committed to ensuring that medications are safe, effective, and of the highest quality. One critical aspect of this commitment is dissolution testing, particularly for enteric-coated tablets. These tablets…

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Solid Dosage form, Tablets

Investigating API Potency Retention in Immediate Release Tablets Over Time

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Investigating API Potency Retention in Immediate Release Tablets Over Time Investigating API Potency Retention in Immediate Release Tablets Over Time Introduction: In the pharmaceutical industry, ensuring the efficacy and safety of medicinal products is paramount. One critical aspect of this is the potency retention of the Active Pharmaceutical Ingredient (API) in immediate release tablets over…

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Solid Dosage form, Tablets

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time

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Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Introduction: The development of sustained release tablets represents a significant advancement in pharmaceutical technology, aiming to provide consistent therapeutic effects over extended periods. These formulations are essential for enhancing patient compliance, minimizing dosing…

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Solid Dosage form, Tablets

Inadequate systems for detecting capsule discoloration under light exposure.

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Inadequate systems for detecting capsule discoloration under light exposure. Inadequate systems for detecting capsule discoloration under light exposure. Introduction: Capsules, both hard and soft gelatin, are one of the most popular solid oral dosage forms in the pharmaceutical industry. However, they are not immune to challenges that can affect their quality and efficacy. One such…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in determining capsule degradation rates under UV light exposure.

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Challenges in determining capsule degradation rates under UV light exposure. Challenges in determining capsule degradation rates under UV light exposure. Introduction: In the pharmaceutical industry, ensuring the stability and efficacy of medications is paramount. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their ease of use and patient compliance….

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

What are the advantages of using pre-formulated direct compression excipients?

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Advantages of Using Pre-formulated Direct Compression Excipients Pre-formulated direct compression excipients are ready-to-use blends of various excipients specifically designed for direct compression tablet manufacturing. These pre-formulated excipients offer several advantages over traditional individual excipients. Here are the key advantages of using pre-formulated direct compression excipients: 1. Simplified Formulation Development Pre-formulated excipients streamline the tablet formulation…

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Tablets

How are multi-layer tablets manufactured?

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Manufacturing Process of Multi-Layer Tablets Multi-layer tablets are pharmaceutical tablets that consist of two or more distinct layers of different drug formulations. These layers may release the active pharmaceutical ingredients (APIs) at different rates or provide other specific functionalities, such as immediate release followed by sustained release. The manufacturing process of multi-layer tablets involves careful…

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Tablets

What are the different tablet scoring techniques?

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Different Tablet Scoring Techniques Tablet scoring is a process used to create a groove or shallow indentation on a tablet’s surface. The scoring facilitates breaking the tablet into smaller parts, allowing patients to adjust the dose as needed. Tablet scoring is particularly useful for patients who have difficulty swallowing or need a lower dosage strength…

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Tablets

How are sustained-release tablets formulated?

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Formulation of Sustained-Release Tablets Sustained-release tablets, also known as extended-release tablets or controlled-release tablets, are designed to release the active pharmaceutical ingredient (API) over an extended period, maintaining a steady and controlled drug release profile. The formulation of sustained-release tablets requires careful selection of excipients and incorporation of drug release mechanisms to achieve the desired…

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Tablets

What is the purpose of using glidants in tablet manufacturing?

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Purpose of Using Glidants in Tablet Manufacturing Glidants, also known as lubricating glidants or flow aids, are additives used in tablet manufacturing to improve the flow properties of the tablet blend. They serve the crucial purpose of enhancing the flowability of powders or granules, making the tablet manufacturing process more efficient and consistent. Glidants play…

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Tablets

Explain the importance of using appropriate lubricants in tablet compression.

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Importance of Using Appropriate Lubricants in Tablet Compression Lubricants play a crucial role in tablet compression, as they help facilitate the tablet manufacturing process and ensure the production of high-quality tablets. Lubricants are added to tablet formulations to reduce friction between the tablet granules and the surfaces of the tablet punches and dies during compression….

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Tablets

How do you troubleshoot tablet sticking during compression?

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Troubleshooting Tablet Sticking During Compression Tablet sticking during compression can be a common problem in tablet manufacturing. It occurs when the tablet blend adheres to the punch faces, leading to difficulties in ejecting the tablets from the dies and affecting tablet quality. Troubleshooting tablet sticking involves identifying the root cause and implementing corrective actions. Here…

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Tablets