Tag: drug release

Challenges in ensuring consistent capsule coating thickness during validation.

April 16, 2025 Admin

Challenges in ensuring consistent capsule coating thickness during validation. Challenges in ensuring consistent capsule coating thickness during validation. Introduction: In the pharmaceutical industry, capsules are a prevalent solid oral dosage form due to their ease of administration and ability to deliver precise dosages. Both hard and soft gelatin capsules can be coated for various reasons…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in disintegration testing for coated capsules.

April 15, 2025 Admin

Poor reproducibility in disintegration testing for coated capsules. Poor reproducibility in disintegration testing for coated capsules Introduction: In the pharmaceutical industry, disintegration testing is a critical quality control measure that ensures that oral dosage forms, such as capsules, break down within a specified time to release their active ingredients. This is particularly important for coated…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with bioequivalence requirements for capsules.

April 9, 2025 Admin

Difficulty in ensuring compliance with bioequivalence requirements for capsules. Difficulty in ensuring compliance with bioequivalence requirements for capsules. Introduction: In the pharmaceutical industry, ensuring that generic formulations are bioequivalent to their branded counterparts is crucial. Bioequivalence ensures that a generic drug releases its active ingredient into the bloodstream at the same rate and level as…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies.

April 9, 2025 Admin

Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies. Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies. Introduction: In the realm of pharmaceuticals, the dissolution testing of capsules is a critical parameter in ensuring the efficacy and safety of drug products. Evaluating capsule dissolution in biorelevant media during…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Identifying Problems in Potency Testing for Extended Release Tablets

March 31, 2025 Admin

Identifying Problems in Potency Testing for Extended Release Tablets Identifying Problems in Potency Testing for Extended Release Tablets Introduction: Extended release tablets are a cornerstone of modern pharmaceutical therapy, providing patients with the convenience of reduced dosing frequency while maintaining therapeutic efficacy over an extended period. Potency testing of these formulations is critical to ensure…

Solid Dosage form, Tablets

Addressing Coating Layer Delamination in Sustained Release Tablets

March 29, 2025 Admin

Addressing Coating Layer Delamination in Sustained Release Tablets Addressing Coating Layer Delamination in Sustained Release Tablets Introduction: The pharmaceutical industry continually seeks to enhance drug delivery systems, with sustained release tablets being a significant innovation. These tablets are designed to release their active ingredients over an extended period, ensuring a consistent therapeutic effect and improved…

Solid Dosage form, Tablets

Troubleshooting Thickness Testing Failures in Enteric-Coated Tablets

March 26, 2025 Admin

Troubleshooting Thickness Testing Failures in Enteric-Coated Tablets Troubleshooting Thickness Testing Failures in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a critical component in the pharmaceutical industry, designed to deliver active ingredients to the intestines without being degraded by stomach acid. The integrity of this enteric coating is vital, and one key quality parameter is the thickness…

Solid Dosage form, Tablets

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing

March 22, 2025 Admin

Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Ensuring Adequate pH Stability in Enteric-Coated Tablets During Testing Introduction: In the pharmaceutical industry, enteric-coated tablets play a crucial role in ensuring that active pharmaceutical ingredients (APIs) are delivered to the intestine, bypassing the acidic environment of the stomach. This not only protects the drug from…

Solid Dosage form, Tablets

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets

March 21, 2025 Admin

Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Investigating Causes of Non-Uniform Dissolution Profiles in Enteric Tablets Introduction: Enteric tablets are specially designed to withstand the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This targeted dissolution is critical for drugs that are sensitive to stomach acid…

Solid Dosage form, Tablets

Ensuring Consistency in Dissolution Testing for Multi-API Tablets

March 16, 2025 Admin

Ensuring Consistency in Dissolution Testing for Multi-API Tablets Ensuring Consistency in Dissolution Testing for Multi-API Tablets Introduction: Dissolution testing is a critical quality control measure in the pharmaceutical industry, particularly for tablets containing multiple active pharmaceutical ingredients (APIs). Ensuring consistency in dissolution testing is vital as it impacts the tablet’s efficacy, safety, and regulatory compliance….

Solid Dosage form, Tablets

Resolving Over-Lubrication Issues in Immediate Release Tablets

March 14, 2025 Admin

Resolving Over-Lubrication Issues in Immediate Release Tablets Resolving Over-Lubrication Issues in Immediate Release Tablets Introduction: Immediate release tablets are a mainstay in the pharmaceutical industry, offering quick onset of action and ease of administration. However, the formulation and manufacturing of these tablets present unique challenges, particularly with lubrication. Over-lubrication can compromise tablet quality, affecting disintegration…

Solid Dosage form, Tablets

Resolving Failures in Disintegration Testing for High-Dose Tablets

March 10, 2025 Admin

Resolving Failures in Disintegration Testing for High-Dose Tablets Resolving Failures in Disintegration Testing for High-Dose Tablets Introduction: In the pharmaceutical industry, the production of high-dose tablets is a critical process that requires rigorous quality control measures to ensure efficacy and safety. Disintegration testing serves as a cornerstone in evaluating the performance of these tablets, as…

Solid Dosage form, Tablets