Tag: Drug formulation

High variability in results of content uniformity testing for low-dose drugs.

March 8, 2025 Admin

High variability in results of content uniformity testing for low-dose drugs. High Variability in Results of Content Uniformity Testing for Low-Dose Drugs Introduction: The pharmaceutical industry is tasked with the critical role of ensuring that every dose of medication administered to patients is safe, effective, and of high quality. One of the major quality control…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Coating Peel-Off During Stability Studies

March 8, 2025 Admin

Addressing Coating Peel-Off During Stability Studies Addressing Coating Peel-Off During Stability Studies Introduction: In the realm of pharmaceutical manufacturing, ensuring the stability and integrity of tablet coatings is paramount. Coatings play a crucial role in protecting the active pharmaceutical ingredient (API), controlling release profiles, improving patient compliance, and enhancing the aesthetic appeal of the product….

Solid Dosage form, Tablets

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes

March 8, 2025 Admin

Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Detecting Core Erosion in Sugar-Coated Tablets During Coating Processes Introduction: The pharmaceutical industry relies heavily on the integrity and efficacy of solid dosage forms like tablets. Among these, sugar-coated tablets have been traditionally used for their aesthetic appeal and ability to mask unpleasant tastes. However, the…

Solid Dosage form, Tablets

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes

March 7, 2025 Admin

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Introduction: In the pharmaceutical industry, coated tablets are among the most common solid dosage forms due to their advantages in masking unpleasant tastes, improving stability, and controlling drug release. However, the process of coating tablets can be highly sensitive…

Solid Dosage form, Tablets

Difficulty in validating cleaning methods for enteric-coated formulations.

March 7, 2025 Admin

Difficulty in validating cleaning methods for enteric-coated formulations. Difficulty in Validating Cleaning Methods for Enteric-Coated Formulations Introduction: In the pharmaceutical industry, maintaining stringent cleanliness standards is crucial to ensure product safety and efficacy. One area that presents significant challenges is the cleaning validation for enteric-coated formulations. These formulations are designed to resist the acidic environment…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in testing for capsule tamper resistance.

March 7, 2025 Admin

Difficulty in testing for capsule tamper resistance. Difficulty in Testing for Capsule Tamper Resistance Introduction: In the pharmaceutical industry, ensuring the integrity and safety of drug products is paramount. Capsules, both hard and soft gelatin, are popular solid oral dosage forms due to their convenience and efficiency in delivering medication. However, they are vulnerable to…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Calibration Failures in Temperature Mapping for Fluid Bed Dryers

March 7, 2025 Admin

Addressing Calibration Failures in Temperature Mapping for Fluid Bed Dryers Addressing Calibration Failures in Temperature Mapping for Fluid Bed Dryers Introduction: Temperature mapping is a critical component in ensuring the consistent and effective operation of fluid bed dryers used in pharmaceutical manufacturing. These dryers are essential for the production of solid dosage forms, particularly tablets,…

Solid Dosage form, Tablets

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing

March 7, 2025 Admin

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Introduction: Coated tablets are a prevalent form of medication delivery in the pharmaceutical industry, designed to improve the stability, appearance, and release characteristics of the active pharmaceutical ingredient (API). The disintegration of these tablets is a critical quality attribute…

Solid Dosage form, Tablets

Ensuring Consistent Moisture Control During Stability Testing of Coated Tablets

March 6, 2025 Admin

Ensuring Consistent Moisture Control During Stability Testing of Coated Tablets Ensuring Consistent Moisture Control During Stability Testing of Coated Tablets Introduction: The pharmaceutical industry is driven by the need for quality and consistency, especially when it comes to drug delivery forms like coated tablets. Stability testing is a critical component in ensuring that these tablets…

Solid Dosage form, Tablets

Addressing API Migration in Bilayer Tablets During Long-Term Testing

March 6, 2025 Admin

Addressing API Migration in Bilayer Tablets During Long-Term Testing Addressing API Migration in Bilayer Tablets During Long-Term Testing Introduction: Bilayer tablets are an innovative pharmaceutical dosage form designed to deliver two different active pharmaceutical ingredients (APIs) or to control the release of a single API over time. However, the process of ensuring the stability and…

Solid Dosage form, Tablets

Optimizing Stability Testing Conditions for Hygroscopic Tablets

March 4, 2025 Admin

Optimizing Stability Testing Conditions for Hygroscopic Tablets Optimizing Stability Testing Conditions for Hygroscopic Tablets Introduction: Hygroscopic tablets, known for their moisture-absorbing properties, pose unique challenges in the realm of pharmaceutical product stability. Stability testing is a crucial component in the lifecycle of drug development, ensuring that a product maintains its integrity, efficacy, and safety throughout…

Solid Dosage form, Tablets

Inadequate systems for detecting capsule discoloration under light exposure.

March 4, 2025 Admin

Inadequate systems for detecting capsule discoloration under light exposure. Inadequate systems for detecting capsule discoloration under light exposure. Introduction: Capsules, both hard and soft gelatin, are one of the most popular solid oral dosage forms in the pharmaceutical industry. However, they are not immune to challenges that can affect their quality and efficacy. One such…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms