Tag: Drug formulation

Ensuring Consistency in Disintegration Time During Long-Term Stability Studies

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Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Ensuring Consistency in Disintegration Time During Long-Term Stability Studies Introduction: In the realm of pharmaceuticals, ensuring consistency in the disintegration time of tablets during long-term stability studies is pivotal for guaranteeing a drug’s efficacy, safety, and patient compliance. Disintegration time is a critical quality attribute that…

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Solid Dosage form, Tablets

Troubleshooting Film Tearing in Heat-Sealed Pouches for Sugar-Coated Tablets

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Troubleshooting Film Tearing in Heat-Sealed Pouches for Sugar-Coated Tablets Troubleshooting Film Tearing in Heat-Sealed Pouches for Sugar-Coated Tablets Introduction: In the pharmaceutical industry, ensuring the integrity of packaging is crucial for maintaining the quality and efficacy of drug products. Sugar-coated tablets, known for their aesthetic appeal and taste masking properties, require specific handling and packaging…

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Solid Dosage form, Tablets

Managing API Degradation in Film-Coated Tablets Stored at High Temperatures

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Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Managing API Degradation in Film-Coated Tablets Stored at High Temperatures Introduction: In the pharmaceutical industry, the stability of Active Pharmaceutical Ingredients (APIs) is crucial for ensuring the efficacy and safety of medications. Film-coated tablets are a popular dosage form, offering benefits such as ease of…

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Solid Dosage form, Tablets

Challenges in predicting the impact of packaging material permeability on capsule stability.

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Challenges in predicting the impact of packaging material permeability on capsule stability. Challenges in predicting the impact of packaging material permeability on capsule stability. Introduction: In the pharmaceutical industry, ensuring the stability of capsules—whether hard or soft gelatin—is a critical component of the drug development process. Packaging plays a pivotal role in preserving the integrity…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for verifying capsule tamper-resistance features.

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Inadequate systems for verifying capsule tamper-resistance features. Inadequate Systems for Verifying Capsule Tamper-Resistance Features Introduction: Ensuring the integrity and safety of pharmaceuticals is paramount in the healthcare industry. Capsules, as one of the most prevalent solid oral dosage forms, require robust tamper-resistance features to protect against contamination, counterfeiting, and unauthorized access. However, inadequate systems for…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions

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Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions Managing Layer Separation in Sugar-Coated Tablets Under Accelerated Conditions Introduction: Sugar-coated tablets have long been a staple in pharmaceutical formulations, offering benefits such as masking unpleasant tastes, improving tablet appearance, and protecting active pharmaceutical ingredients (APIs) from environmental factors. However, they also present unique challenges, particularly…

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Solid Dosage form, Tablets

Investigating Impact of Oxidative Stress on Coated Tablet Stability

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Investigating Impact of Oxidative Stress on Coated Tablet Stability Investigating Impact of Oxidative Stress on Coated Tablet Stability Introduction: In the pharmaceutical industry, the stability of coated tablets is a critical factor in ensuring drug efficacy and safety over their shelf life. Coated tablets are designed to protect the active pharmaceutical ingredients (APIs) from environmental…

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Solid Dosage form, Tablets

Poor correlation between in vitro dissolution and stability data.

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Poor correlation between in vitro dissolution and stability data. Poor correlation between in vitro dissolution and stability data. Introduction: In the pharmaceutical industry, the correlation between in vitro dissolution and stability data is pivotal for ensuring the efficacy and safety of solid oral dosage forms, particularly capsules. Dissolution testing is a key quality control measure…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for validating capsule hardness testing equipment.

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Inadequate systems for validating capsule hardness testing equipment. Inadequate systems for validating capsule hardness testing equipment. Introduction: The pharmaceutical industry demands rigorous quality control measures to ensure the safety and efficacy of its products. Among these measures, validating equipment used for testing the hardness of capsules is crucial. Capsule hardness is an essential parameter that…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in assessing the stability of capsules containing low-dose APIs.

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Difficulty in assessing the stability of capsules containing low-dose APIs. Difficulty in assessing the stability of capsules containing low-dose APIs. Introduction: In the pharmaceutical industry, ensuring the stability of drug products is paramount, particularly when dealing with capsules containing low-dose Active Pharmaceutical Ingredients (APIs). Stability refers to the ability of a drug product to maintain…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Temperature Fluctuations in Stability Testing Chambers

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Managing Temperature Fluctuations in Stability Testing Chambers Managing Temperature Fluctuations in Stability Testing Chambers Introduction: Stability testing is a critical component of the pharmaceutical development process, ensuring that drug products maintain their intended quality, safety, and efficacy throughout their shelf life. Central to this process are stability testing chambers, which simulate various environmental conditions to…

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Solid Dosage form, Tablets

Challenges in validating encapsulation equipment for multi-drug formulations.

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Challenges in validating encapsulation equipment for multi-drug formulations. Challenges in validating encapsulation equipment for multi-drug formulations. Introduction: In the ever-evolving landscape of pharmaceutical manufacturing, the encapsulation of multi-drug formulations has emerged as a strategic approach to enhance therapeutic outcomes and patient compliance. However, the validation of encapsulation equipment for such complex formulations presents unique challenges….

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms