Tag: drug formulation challenges

Managing Layer Separation in Bilayer Tablets Under Accelerated Conditions

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Managing Layer Separation in Bilayer Tablets Under Accelerated Conditions Managing Layer Separation in Bilayer Tablets Under Accelerated Conditions Introduction: Bilayer tablets are increasingly utilized in the pharmaceutical industry to deliver multiple drugs or different release profiles in a single dosage form. This innovative approach not only enhances patient compliance but also offers significant benefits in…

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Solid Dosage form, Tablets

Managing Brittleness in Hygroscopic Tablets Stored Under Dry Conditions

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Managing Brittleness in Hygroscopic Tablets Stored Under Dry Conditions Managing Brittleness in Hygroscopic Tablets Stored Under Dry Conditions Introduction: In the pharmaceutical industry, maintaining the integrity of solid dosage forms is crucial for ensuring efficacy and safety. Among these forms, hygroscopic tablets present unique challenges due to their affinity for moisture, which can significantly affect…

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Solid Dosage form, Tablets

Inadequate systems for monitoring capsule release profiles.

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Inadequate systems for monitoring capsule release profiles. Inadequate systems for monitoring capsule release profiles. Introduction: The pharmaceutical industry is a cornerstone of modern healthcare, where ensuring the efficacy and safety of medications is paramount. Solid oral dosage forms, particularly capsules, play a significant role due to their convenience and patient compliance. However, the inadequacy of…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in detecting microscopic defects in capsule shells.

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Difficulty in detecting microscopic defects in capsule shells. Difficulty in Detecting Microscopic Defects in Capsule Shells Introduction: Capsules are one of the most popular solid oral dosage forms in the pharmaceutical industry, offering a convenient and effective means of drug delivery. However, maintaining the integrity and quality of capsule shells is crucial, as defects can…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with validating capsule sealing for capsules with delayed-release profiles.

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Problems with validating capsule sealing for capsules with delayed-release profiles. Problems with Validating Capsule Sealing for Capsules with Delayed-Release Profiles Introduction: In the pharmaceutical industry, the demand for delayed-release capsules has been on the rise due to their ability to deliver active ingredients at specific sites within the gastrointestinal tract. These capsules are crucial for…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets

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Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to resist the acidic environment of the stomach and release active pharmaceutical ingredients (APIs) in the more neutral pH of the intestines. This controlled release profile is…

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Solid Dosage form, Tablets

Managing Tablet Core Erosion in Enteric-Coated Tablets

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Managing Tablet Core Erosion in Enteric-Coated Tablets Managing Tablet Core Erosion in Enteric-Coated Tablets Introduction: Enteric-coated tablets represent a sophisticated drug delivery system designed to bypass the acidic environment of the stomach and to release their active ingredients in the more neutral pH of the intestines. This method of delivery is essential for drugs that…

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Solid Dosage form, Tablets

Managing Over-Compression in Tablets with High-Dose APIs

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Managing Over-Compression in Tablets with High-Dose APIs Managing Over-Compression in Tablets with High-Dose APIs Introduction: The pharmaceutical industry is increasingly challenged with the development and manufacturing of tablets that contain high-dose Active Pharmaceutical Ingredients (APIs). While these tablets are crucial for ensuring therapeutic efficacy, they come with a unique set of challenges, particularly in terms…

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Solid Dosage form, Tablets

High variability in content uniformity testing for multi-drug capsules.

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High variability in content uniformity testing for multi-drug capsules. High Variability in Content Uniformity Testing for Multi-Drug Capsules Introduction: Content uniformity is a critical quality attribute in the manufacturing of pharmaceuticals, ensuring that each dose in a batch contains the intended amount of active pharmaceutical ingredients (APIs). In the context of multi-drug capsules, achieving content…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Ensuring Robustness of API Potency in Sustained Release Tablets Over Time

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Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Ensuring Robustness of API Potency in Sustained Release Tablets Over Time Introduction: The development of sustained release tablets represents a significant advancement in pharmaceutical technology, aiming to provide consistent therapeutic effects over extended periods. These formulations are essential for enhancing patient compliance, minimizing dosing…

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Solid Dosage form, Tablets

High variability in stability data for oil-filled capsules.

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High variability in stability data for oil-filled capsules. High variability in stability data for oil-filled capsules. Introduction: In the pharmaceutical industry, maintaining the stability of medicinal products is crucial to ensure their safety, efficacy, and quality over their shelf life. Among various dosage forms, oil-filled capsules—encompassing both hard and soft gelatin variants—present unique challenges in…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Investigating Poor API Distribution in Content Uniformity Tests

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Investigating Poor API Distribution in Content Uniformity Tests Investigating Poor API Distribution in Content Uniformity Tests Introduction: The pharmaceutical industry is heavily reliant on the precision and consistency of its products. One critical aspect of ensuring drug efficacy and safety is maintaining uniformity in the active pharmaceutical ingredient (API) distribution within solid dosage forms like…

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Solid Dosage form, Tablets