Tag: Drug delivery systems

High variability in stability data for oil-filled capsules.

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High variability in stability data for oil-filled capsules. High variability in stability data for oil-filled capsules. Introduction: In the pharmaceutical industry, maintaining the stability of medicinal products is crucial to ensure their safety, efficacy, and quality over their shelf life. Among various dosage forms, oil-filled capsules—encompassing both hard and soft gelatin variants—present unique challenges in…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Managing Failures in Stress Tests for Sustained Release Tablets

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Managing Failures in Stress Tests for Sustained Release Tablets Managing Failures in Stress Tests for Sustained Release Tablets Introduction: Sustained release tablets are critical in modern pharmaceutical formulations, offering controlled drug release over extended periods. These tablets enhance patient compliance by reducing the frequency of dosing and maintaining therapeutic drug levels. However, ensuring their effectiveness…

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Solid Dosage form, Tablets

Ensuring Coating Uniformity in Sustained Release Tablets During Production

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Ensuring Coating Uniformity in Sustained Release Tablets During Production Ensuring Coating Uniformity in Sustained Release Tablets During Production Introduction: The production of sustained release tablets is a cornerstone of modern pharmaceutical manufacturing, offering controlled drug delivery over extended periods. Coating uniformity is crucial in these tablets to ensure consistent drug release rates, optimal therapeutic outcomes,…

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Solid Dosage form, Tablets

Resolving Coating Integrity Issues in Enteric-Coated Tablets

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Resolving Coating Integrity Issues in Enteric-Coated Tablets Resolving Coating Integrity Issues in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a critical component of modern pharmaceutical formulations. These specialized coatings are designed to withstand the acidic environment of the stomach, ensuring that the active pharmaceutical ingredient (API) is released in the more neutral pH of the small…

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Solid Dosage form, Tablets

Difficulty in validating capsule filling for lipid-based formulations.

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Difficulty in validating capsule filling for lipid-based formulations. Difficulty in Validating Capsule Filling for Lipid-Based Formulations Introduction: Lipid-based formulations have gained significant attention in the pharmaceutical industry due to their potential to improve the bioavailability of poorly soluble drugs. As a result, encapsulating these formulations, particularly in hard or soft gelatin capsules, has become increasingly…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Controlling Over-Sensitivity to Temperature in Coated Tablet Processes

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Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Controlling Over-Sensitivity to Temperature in Coated Tablet Processes Introduction: In the pharmaceutical industry, coated tablets are among the most common solid dosage forms due to their advantages in masking unpleasant tastes, improving stability, and controlling drug release. However, the process of coating tablets can be highly sensitive…

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Solid Dosage form, Tablets

Difficulty in testing gelatin-free capsules for uniformity.

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Difficulty in testing gelatin-free capsules for uniformity. Difficulty in Testing Gelatin-Free Capsules for Uniformity Introduction: In the evolving landscape of pharmaceutical formulations, gelatin-free capsules have emerged as a significant advancement, especially for those seeking vegetarian or vegan alternatives. These capsules not only cater to dietary preferences but also overcome some of the limitations associated with…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing

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Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Troubleshooting Non-Uniform Disintegration in Coated Tablets During Testing Introduction: Coated tablets are a prevalent form of medication delivery in the pharmaceutical industry, designed to improve the stability, appearance, and release characteristics of the active pharmaceutical ingredient (API). The disintegration of these tablets is a critical quality attribute…

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Solid Dosage form, Tablets

Challenges in validating capsule performance for pediatric formulations.

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Challenges in validating capsule performance for pediatric formulations. Challenges in validating capsule performance for pediatric formulations. Introduction: In the realm of pharmaceutical development, pediatric formulations pose unique challenges that require careful consideration, particularly when it comes to solid oral dosage forms like capsules. Pediatric patients differ significantly from adults in terms of physiology, pharmacokinetics, and…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Non-Uniform API Distribution in Extended Release Tablets Over Time

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Resolving Non-Uniform API Distribution in Extended Release Tablets Over Time Resolving Non-Uniform API Distribution in Extended Release Tablets Over Time Introduction: The pharmaceutical industry is constantly evolving, with a significant focus on developing efficient drug delivery systems. Extended release tablets are a crucial component of this landscape, designed to release active pharmaceutical ingredients (APIs) over…

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Solid Dosage form, Tablets

Ensuring Robustness in Thickness Testing for Extended Release Tablets

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Ensuring Robustness in Thickness Testing for Extended Release Tablets Ensuring Robustness in Thickness Testing for Extended Release Tablets Introduction: In the pharmaceutical industry, maintaining the robustness and consistency of extended release tablets is paramount for both efficacy and safety. Thickness testing of these tablets plays a crucial role in ensuring their quality and performance. Variability…

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Solid Dosage form, Tablets

Challenges in validating capsule sealing for capsules with modified-release coatings.

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Challenges in validating capsule sealing for capsules with modified-release coatings. Challenges in validating capsule sealing for capsules with modified-release coatings Introduction: In the pharmaceutical industry, capsules remain a popular dosage form due to their versatility and patient compliance. Specifically, capsules with modified-release coatings offer the advantage of controlled drug release, enhancing therapeutic efficacy and minimizing…

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Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms