Tag: Dosage Formulation

Difficulty in testing capsules with multi-phase drug release profiles.

April 5, 2025 Admin

Difficulty in testing capsules with multi-phase drug release profiles. Difficulty in testing capsules with multi-phase drug release profiles. Introduction: In the ever-evolving landscape of pharmaceutical development, capsules with multi-phase drug release profiles have emerged as a sophisticated solution to optimize therapeutic outcomes. These formulations are designed to release active ingredients at different intervals, ensuring prolonged…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for detecting powder compaction issues during filling.

April 2, 2025 Admin

Inadequate systems for detecting powder compaction issues during filling. Inadequate systems for detecting powder compaction issues during filling. Introduction: In the pharmaceutical industry, the precision and reliability of capsule filling are paramount to ensure product efficacy and patient safety. Hard and soft gelatin capsules are popular dosage forms, offering versatility in delivering active pharmaceutical ingredients…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High variability in capsule weight due to uneven powder blending.

March 31, 2025 Admin

High variability in capsule weight due to uneven powder blending. High Variability in Capsule Weight Due to Uneven Powder Blending Introduction: In the pharmaceutical industry, ensuring consistent capsule weight is critical for maintaining drug efficacy and patient safety. High variability in capsule weight can lead to suboptimal therapeutic outcomes and regulatory non-compliance. Uneven powder blending…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Identifying Root Causes of Content Non-Uniformity in Tablets

March 29, 2025 Admin

Identifying Root Causes of Content Non-Uniformity in Tablets Identifying Root Causes of Content Non-Uniformity in Tablets Introduction: Content uniformity in tablets is a critical quality attribute that ensures each tablet contains an equal amount of the active pharmaceutical ingredient (API). This consistency is vital for efficacy, safety, and regulatory compliance. The challenge of maintaining content…

Solid Dosage form, Tablets

Poor standardization of capsule quality specifications.

March 18, 2025 Admin

Poor standardization of capsule quality specifications. Poor standardization of capsule quality specifications. Introduction: In the pharmaceutical industry, capsules represent one of the most common solid oral dosage forms, offering a convenient and effective means of delivering medications. However, the standardization of capsule quality specifications remains a significant challenge for manufacturers. With a vast array of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

High variability in content uniformity testing for multi-drug capsules.

March 18, 2025 Admin

High variability in content uniformity testing for multi-drug capsules. High Variability in Content Uniformity Testing for Multi-Drug Capsules Introduction: Content uniformity is a critical quality attribute in the manufacturing of pharmaceuticals, ensuring that each dose in a batch contains the intended amount of active pharmaceutical ingredients (APIs). In the context of multi-drug capsules, achieving content…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets

March 15, 2025 Admin

Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Addressing Fines Segregation in Roller Compaction for Large-Scale Tablets Introduction: In the realm of pharmaceutical manufacturing, roller compaction is a critical granulation method frequently employed for the production of large-scale tablets. This process is favored for its ability to handle heat and moisture-sensitive compounds without requiring…

Solid Dosage form, Tablets

Addressing Layer Delamination Issues During Disintegration Testing

March 8, 2025 Admin

Addressing Layer Delamination Issues During Disintegration Testing Addressing Layer Delamination Issues During Disintegration Testing Introduction: In the world of pharmaceuticals, ensuring the integrity of solid dosage forms like tablets is of utmost importance. Layer delamination, a challenge often encountered during disintegration testing, can compromise the efficacy and safety of a pharmaceutical product. This phenomenon occurs…

Solid Dosage form, Tablets