Tag: dissolution testing

Challenges in testing capsules with delayed-release profiles.

April 6, 2025 Admin

Challenges in testing capsules with delayed-release profiles. Challenges in testing capsules with delayed-release profiles. Introduction: Delayed-release capsules are a crucial innovation in pharmaceutical science, allowing for the targeted delivery of medications to specific areas of the gastrointestinal tract. By releasing the active ingredient at a predetermined time or location, these capsules enhance the drug’s efficacy…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in testing capsules with multi-phase drug release profiles.

April 5, 2025 Admin

Difficulty in testing capsules with multi-phase drug release profiles. Difficulty in testing capsules with multi-phase drug release profiles. Introduction: In the ever-evolving landscape of pharmaceutical development, capsules with multi-phase drug release profiles have emerged as a sophisticated solution to optimize therapeutic outcomes. These formulations are designed to release active ingredients at different intervals, ensuring prolonged…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate protocols for evaluating shell-to-fill interaction effects.

April 5, 2025 Admin

Inadequate protocols for evaluating shell-to-fill interaction effects. Inadequate Protocols for Evaluating Shell-to-Fill Interaction Effects in Capsules Introduction: In the pharmaceutical industry, solid oral dosage forms such as capsules are a staple due to their ease of administration and versatility. Capsules, which can be either hard or soft gelatin, serve as a vehicle to deliver active…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in API release profiles over the product’s shelf life.

April 4, 2025 Admin

Poor reproducibility in API release profiles over the product’s shelf life. Poor reproducibility in API release profiles over the product’s shelf life. Introduction: The reproducibility of Active Pharmaceutical Ingredient (API) release profiles is a critical component in the pharmaceutical industry, particularly for solid oral dosage forms such as capsules. Ensuring consistent drug release over a…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of analytical methods for multi-drug capsule formulations.

April 3, 2025 Admin

Poor validation of analytical methods for multi-drug capsule formulations. Poor validation of analytical methods for multi-drug capsule formulations. Introduction: In the pharmaceutical industry, the development of multi-drug capsule formulations is a sophisticated process that requires precision and accuracy. The validation of analytical methods for these formulations is crucial as it ensures the quality, efficacy, and…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Lack of validated protocols for testing highly hydrophobic APIs.

April 2, 2025 Admin

Lack of validated protocols for testing highly hydrophobic APIs. Lack of validated protocols for testing highly hydrophobic APIs. Introduction: In the pharmaceutical industry, the development and testing of Active Pharmaceutical Ingredients (APIs) are crucial for ensuring drug efficacy and safety. However, one significant challenge that researchers and formulators face is dealing with highly hydrophobic APIs,…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with ensuring consistent capsule appearance during accelerated validation studies.

April 1, 2025 Admin

Problems with ensuring consistent capsule appearance during accelerated validation studies. Problems with ensuring consistent capsule appearance during accelerated validation studies. Introduction: In the pharmaceutical industry, ensuring the consistent appearance of capsules is crucial for maintaining product quality and consumer trust. During accelerated validation studies, which are designed to predict the long-term stability of a product…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Identifying Problems in Potency Testing for Extended Release Tablets

March 31, 2025 Admin

Identifying Problems in Potency Testing for Extended Release Tablets Identifying Problems in Potency Testing for Extended Release Tablets Introduction: Extended release tablets are a cornerstone of modern pharmaceutical therapy, providing patients with the convenience of reduced dosing frequency while maintaining therapeutic efficacy over an extended period. Potency testing of these formulations is critical to ensure…

Solid Dosage form, Tablets

Troubleshooting Failures in Stability Testing for Film-Coated Tablets

March 30, 2025 Admin

Troubleshooting Failures in Stability Testing for Film-Coated Tablets Troubleshooting Failures in Stability Testing for Film-Coated Tablets Introduction: Stability testing is a critical component in the lifecycle of any pharmaceutical product, especially for film-coated tablets. These tests ensure that the product maintains its intended efficacy, safety, and quality throughout its shelf life. Stability testing evaluates how…

Solid Dosage form, Tablets

Problems with ensuring complete removal of oils and fats from soft gelatin equipment.

March 24, 2025 Admin

Problems with ensuring complete removal of oils and fats from soft gelatin equipment. Problems with ensuring complete removal of oils and fats from soft gelatin equipment. Introduction: In the pharmaceutical industry, soft gelatin capsules are a popular dosage form due to their patient-friendly administration and ability to encapsulate a wide range of substances. However, the…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Troubleshooting Dissolution Failures in Enteric-Coated Tablets

March 24, 2025 Admin

Troubleshooting Dissolution Failures in Enteric-Coated Tablets Troubleshooting Dissolution Failures in Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to bypass the acidic environment of the stomach and dissolve in the more neutral pH of the intestines. This coating is crucial for drugs that can be degraded by stomach acid or can…

Solid Dosage form, Tablets

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets

March 24, 2025 Admin

Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Resolving Issues in Acid Resistance Tests for Enteric-Coated Tablets Introduction: Enteric-coated tablets are a sophisticated pharmaceutical dosage form designed to resist the acidic environment of the stomach and release active pharmaceutical ingredients (APIs) in the more neutral pH of the intestines. This controlled release profile is…

Solid Dosage form, Tablets