Tag: dissolution testing

Poor correlation between in vitro dissolution and stability data.

April 24, 2025 Admin

Poor correlation between in vitro dissolution and stability data. Poor correlation between in vitro dissolution and stability data. Introduction: In the pharmaceutical industry, the correlation between in vitro dissolution and stability data is pivotal for ensuring the efficacy and safety of solid oral dosage forms, particularly capsules. Dissolution testing is a key quality control measure…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing

April 21, 2025 Admin

Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing Resolving Disintegration Failures in Sugar-Coated Tablets During Stability Testing Introduction: Sugar-coated tablets are a popular dosage form in the pharmaceutical industry, valued for their aesthetic appeal and ability to mask unpleasant tastes. However, these advantages can be overshadowed by challenges encountered during stability testing, particularly disintegration…

Solid Dosage form, Tablets

Poor reproducibility in validation data for modified-release capsules.

April 17, 2025 Admin

Poor reproducibility in validation data for modified-release capsules. Poor reproducibility in validation data for modified-release capsules. Introduction: Modified-release capsules are pivotal in modern therapeutics, offering controlled drug delivery that improves patient compliance and therapeutic outcomes. However, ensuring the reproducibility of validation data for these formulations is crucial in maintaining their efficacy and safety. Inconsistent validation…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate systems for monitoring capsule release profiles.

April 17, 2025 Admin

Inadequate systems for monitoring capsule release profiles. Inadequate systems for monitoring capsule release profiles. Introduction: The pharmaceutical industry is a cornerstone of modern healthcare, where ensuring the efficacy and safety of medications is paramount. Solid oral dosage forms, particularly capsules, play a significant role due to their convenience and patient compliance. However, the inadequacy of…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Challenges in testing soft gelatin capsules with high oil content.

April 16, 2025 Admin

Challenges in testing soft gelatin capsules with high oil content. Challenges in testing soft gelatin capsules with high oil content Introduction: Soft gelatin capsules are a popular dosage form in the pharmaceutical industry, offering unique advantages such as improved bioavailability and patient compliance. However, when these capsules contain high oil content, they present significant challenges…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in disintegration testing for coated capsules.

April 15, 2025 Admin

Poor reproducibility in disintegration testing for coated capsules. Poor reproducibility in disintegration testing for coated capsules Introduction: In the pharmaceutical industry, disintegration testing is a critical quality control measure that ensures that oral dosage forms, such as capsules, break down within a specified time to release their active ingredients. This is particularly important for coated…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor reproducibility in validation data for delayed-release capsules.

April 14, 2025 Admin

Poor reproducibility in validation data for delayed-release capsules. Poor reproducibility in validation data for delayed-release capsules. Introduction: In the realm of pharmaceutical manufacturing, ensuring the consistency and reliability of delayed-release capsules is paramount. These capsules are engineered to resist the acidic environment of the stomach, allowing the active pharmaceutical ingredient (API) to be released in…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate validation of capsule disintegration profiles for multi-particulate capsules.

April 13, 2025 Admin

Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Inadequate validation of capsule disintegration profiles for multi-particulate capsules. Introduction: In the pharmaceutical industry, the validation of capsule disintegration profiles is a critical aspect of ensuring drug efficacy and patient safety. This is particularly important for multi-particulate capsules, which can offer benefits such as improved bioavailability…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Problems with maintaining consistent dissolution profiles over the product’s shelf life.

April 13, 2025 Admin

Problems with maintaining consistent dissolution profiles over the product’s shelf life. Problems with maintaining consistent dissolution profiles over the product’s shelf life. Introduction: The dissolution profile of a pharmaceutical product is a critical parameter that impacts its efficacy and safety. Consistency in dissolution profiles over the product’s shelf life ensures that the drug is released…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Poor validation of capsule disintegration profiles for capsules stored under stressed conditions.

April 11, 2025 Admin

Poor validation of capsule disintegration profiles for capsules stored under stressed conditions. Poor validation of capsule disintegration profiles for capsules stored under stressed conditions. Introduction: In the pharmaceutical industry, ensuring the effective disintegration of capsules is crucial for the drug’s efficacy and safety. Disintegration testing is an essential quality control measure that determines whether capsules…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Difficulty in ensuring compliance with bioequivalence requirements for capsules.

April 9, 2025 Admin

Difficulty in ensuring compliance with bioequivalence requirements for capsules. Difficulty in ensuring compliance with bioequivalence requirements for capsules. Introduction: In the pharmaceutical industry, ensuring that generic formulations are bioequivalent to their branded counterparts is crucial. Bioequivalence ensures that a generic drug releases its active ingredient into the bloodstream at the same rate and level as…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms

Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies.

April 9, 2025 Admin

Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies. Inadequate methods for evaluating capsule dissolution in biorelevant media during stability studies. Introduction: In the realm of pharmaceuticals, the dissolution testing of capsules is a critical parameter in ensuring the efficacy and safety of drug products. Evaluating capsule dissolution in biorelevant media during…

Capsules (Hard & Soft Gelatin), Solid Oral Dosage Forms